Difference between revisions of "Team:HSiTAIWAN/Background"

Background

Introduction

Chinese herb medicine has been used worldwide, particularly in Asia for thousands of year. Many safety concerns of toxins and metal contamination in Chinese medicine use have been raised.

In our project, we aim at playing a role of bridging synthetic biology science and social need by devoting our effect in analysis of the scope of Chinese medicine in Taiwan, identification the problems or issues in use, regulation and screening of Chinese herb medicine. Our goal is to design an eco-friendly and safe biosensor product, which is low-cost, effective and can be used by any one to screen toxins in Chinese medicine.

Figure 1. The Project Framework of Herb Taster

Chinese Medicine

In Asia, Chinese herb medicine plays an important role in Chinese food culture. Not only serving flavor aide, Chinese herb medicine has been used for health promotion, disease prevention, symptom relief, and illness treatment in Asia for thousands of years. In the past decade, use of Chinese herb as alternative medicine in copying with diseases has become more popular in western countries.

Figure 1a Chinese herb medicine in Chinese food culture

According to the social epidemiology analysis on use of Chinese medicine (in our Human Practice)(Table 1), we found that over 5% percent of Taiwanese people using Chinese medicine as the major medical resources for illness treatment. In 2013, over 10% of the Taiwan population had a least one outpatient visits of Chinese medicine service in the past month before interview survey date.

In our analysis, we also found evidence of potential problems in using Chinese medicine in Taiwan (Table 2). There were only neear one third of the Taiwanese population knowing that our government imposes GMP regulation on the manufacturing Chinese medicine and that use of Chinese medicine requires a doctor’s precription. However, there was 6.8% of them reporting the experience of purchase Chinese medicine without the prescription. Inadequate knowledge and inappropriate use of Chinese medicince implies that our population are exposed to potential risks of health hazards.

However, potential risk of using Chinese medicine is not only limit to people’s misuse of Chinese herb medicine. The major safety concerns about Chinese medicine is toxin contamination. There have studies and media reporting problem of toxin contamination in Chinese herb medicine.

Heavy metals and mycotoxins are the two main types of toxins contamination in Chinese medicine. These heavy metals and mycotoxins are toxic and thus harmful to human and animal’s health.

Figure 2. Potential Contamination in Chinese Herb Medicine

In Asian medical and food culture, Chinese herb medicine is commonly used, not only as medicine for disease treatment but also as nutrient supplements for health improvement. Due to the pattern of long-term use , safety concerns on toxins in Chinese medicine is taken into consideration seriously by the experts and government in Taiwan, probably more aggressively than the other countries in regulating food safety.

Learning from our field work of Human Practice, we understood issues in securing the safety of Chinese medicine. We interviewed and visited two Taiwan government divisions of Ministry of Health and Welfare: the department of Chinese Medicine and Pharmacy and Food and Drug Safety Administration. We knew in advance that on October 1, 2016 our government would amend the regulation and inaugurated new policy on Chinese medicine safety, including raising the standard of toxin limit and expanding the screening scope to all Chinese medicine. Our government has endeavored to secure the safety of Chinese medicine use, however, facing difficulties and challenges.

Challenges

To ensure safe use of Chinese medicines, monitoring and detecting heavy metals and toxins in Chinese herb medicines become critically important. Nevertheless, this task is especially tough for the Taiwan government for two reasons.

1. High economic cost of detection technology

Although there are a few methods (for example: ICP-MS) to detect these harmful substances (Yuan et al, 2010), most of the procedures rely on abundant laboratory works and expensive equipment. Accordingly, heavy metal detections often turn out to become expensive, time consuming, and unreachable to most people. (Ernst & Coon, 2001).

2.2. Scope and scale of monitoring

Because of limitation in geography, climate, and environment, Taiwan’s demand for Chinese herb medicine maily relies on imporation. Without inter-country collaboration, the quality of Chinese herb medicine depends on the regulation and polices of origin countries. Our GMP regulation on manufacturing Chinese medicine can’t be applied to these foreign producers of Chinese herb medicine. Thus, there is no way for our government regulate and secure the foreign source of Chinere herb medicine.

In inspection, the government can only randomly inspect Chinese herb medicine at imports and in the markets. How effective this policy can assure the safety of Chinese herb medicines depends on the sampling scheme which can effectively identify Chinese herb medicine of poor quality. However, mycotoxin can be produced in any condition, not limit to markets. It could be restarurant and households, whenever the environment is humid and warm.

Figure 3. Difficulties in Monitoring the Safety of Chinese Herb Medicine

Thus, it is necessary for us to come up with new ideas to overcome the current situation. There are three aspects to solve this problem: financial support, labor, and detection method. While the first two acquires political implements, which may go through a whole lot of rigmarole; our goal is to improve the third option, detection method.

Solution

To help the public stop taking the toxin-containing Chinese medicines, we decide to combine science and social science strategies. By applying synthetic biology technology, we create some “Shen-Nong” E coli who enable detect the heavy metal and toxin in Chinese medicines. We culture different types of E. coli in our bio-kit to detect copper, lead, arsenic, and aflatoxin respectively. We expect that these “Shen-Nong” E coli may detect certain types of heavy metal or toxin in Chinese herbal medicines and express different levels of fluorescence intensity in accordance to toxin doseages. Meanwhile, we initiate multi-facted outreach apporach to advocate safety issues of Chinese medicines and bio-technology, as well as promote our bio-kit products to the public, experts, and scientists.

Application

Our user-friendly bio-kit products are developed to detect heavy metal or toxin in compound materials. Currently, these bio-kit products are used to screen toxic substances in Chinese herbal medicines. In the future, we expect our bio-kit can be modified and used in detecting heavy metal or toxin in other daily products, such as lead poising in makeup and cosmetic products. In hope, the public can take the advantages of these bio-kit products to early detect harmful toxin contaminations in the daily products, and empower people to become a modern Shen-Nong who can guard our health and environment.