Difference between revisions of "Team:XJTLU-CHINA/Model"

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<p> In the model part, we take the perspective of stochastic process to study the mutagenesis mechanism. We used an effective mathematical tool called branching process to describe the mutation process of RNAs through RNA replication of several generations. The limit behavior of the process is also studied to give an expected outcome of the DNA product.  
 
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Also, we modified a previous algorithm to design the intron. A training set is used to score each position in the DNA sequences and find the potential target site positions. This algorithm is then realized using MATLAB. </p>
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<h2> Modeling</h2>
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<p>Mathematical models and computer simulations provide a great way to describe the function and operation of BioBrick Parts and Devices. Synthetic Biology is an engineering discipline, and part of engineering is simulation and modeling to determine the behavior of your design before you build it. Designing and simulating can be iterated many times in a computer before moving to the lab. This award is for teams who build a model of their system and use it to inform system design or simulate expected behavior in conjunction with experiments in the wetlab.</p>
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<h5> Inspiration </h5>
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Here are a few examples from previous teams:
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<li><a href="https://2014.igem.org/Team:ETH_Zurich/modeling/overview">ETH Zurich 2014</a></li>
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<li><a href="https://2014.igem.org/Team:Waterloo/Math_Book">Waterloo 2014</a></li>
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Revision as of 16:54, 12 October 2016

In the model part, we take the perspective of stochastic process to study the mutagenesis mechanism. We used an effective mathematical tool called branching process to describe the mutation process of RNAs through RNA replication of several generations. The limit behavior of the process is also studied to give an expected outcome of the DNA product. Also, we modified a previous algorithm to design the intron. A training set is used to score each position in the DNA sequences and find the potential target site positions. This algorithm is then realized using MATLAB.