Difference between revisions of "UofC Calgary"
Syedjafri97 (Talk | contribs) |
Syedjafri97 (Talk | contribs) |
||
| (23 intermediate revisions by the same user not shown) | |||
| Line 15: | Line 15: | ||
{{assets/base/css/custom.css}} | {{assets/base/css/custom.css}} | ||
{{assets/google-fonts.css}} | {{assets/google-fonts.css}} | ||
| + | {{assets/plugins/jquery.min.js}} | ||
| + | {{assets/plugins/jquery-migrate.min.js}} | ||
| + | {{assets/plugins/bootstrap/js/bootstrap.min.js}} | ||
| + | {{assets/plugins/revo-slider/js/jquery.themepunch.tools.min.js}} | ||
| + | {{assets/plugins/revo-slider/js/jquery.themepunch.revolution.min.js}} | ||
| + | {{assets/plugins/cubeportfolio/js/jquery.cubeportfolio.min.js}} | ||
| + | {{assets/plugins/owl-carousel/owl.carousel.min.js}} | ||
| + | {{assets/plugins/counterup/jquery.waypoints.min.js}} | ||
| + | {{assets/plugins/counterup/jquery.counterup.min.js}} | ||
| + | {{assets/plugins/fancybox/jquery.fancybox.pack.js}} | ||
| + | {{assets/base/js/components.js}} | ||
| + | {{assets/base/js/app.js}} | ||
<html lang="en"> | <html lang="en"> | ||
| Line 29: | Line 41: | ||
<meta content="" name="author"/> | <meta content="" name="author"/> | ||
| − | <link rel="shortcut icon" href="favicon.ico"/ | + | <link rel="shortcut icon" href="favicon.ico"/> |
</head> | </head> | ||
<body class="c-layout-header-fixed"> | <body class="c-layout-header-fixed"> | ||
| Line 267: | Line 279: | ||
<!-- BEGIN: PAGE CONTENT --> | <!-- BEGIN: PAGE CONTENT --> | ||
<!-- BEGIN: LAYOUT/SLIDERS/REVO-SLIDER-1 --> | <!-- BEGIN: LAYOUT/SLIDERS/REVO-SLIDER-1 --> | ||
| − | + | <!--BEGIN: SLIDE #1 --> | |
| − | + | <img alt="" src="https://static.igem.org/mediawiki/2016/e/e1/Bg-8.png" data-bgposition="center center" data-bgfit="cover" data-bgrepeat="no-repeat" style="width: 100%; height: 100%;"> | |
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
| − | + | ||
<!-- END: LAYOUT/SLIDERS/REVO-SLIDER-1 --> | <!-- END: LAYOUT/SLIDERS/REVO-SLIDER-1 --> | ||
<div class="c-content-box c-size-md c-bg-darkblue c-no-bottom-padding"> | <div class="c-content-box c-size-md c-bg-darkblue c-no-bottom-padding"> | ||
| + | <div class="container"> | ||
| + | <div class="c-content-product-1 c-opt-1"> | ||
| + | <div class="c-content-title-1"> | ||
| + | <h3 class="c-center c-font-uppercase c-font-bold" style="color:#EBDEBE">Our Project</h3> | ||
| + | <div class="c-line-center"></div> | ||
| + | </div> | ||
| + | |||
| + | <div class="row"> | ||
| + | <div class="col-md-4 wow animate slideInUp" style="visibility: visible; animation-name: slideInUp;"> | ||
| + | <div class="c-media"> | ||
| + | <img src="https://static.igem.org/mediawiki/2016/2/2d/Space-suit.png" alt=""> </div> | ||
| + | </div> | ||
| + | <div class="col-md-8 c-no-bottom-padding"> | ||
| + | <div class="c-body" style=" | ||
| + | padding-top: 0px;"> | ||
| + | <ul class="c-row"> | ||
| + | <li class="wow animate fadeInUp" style="visibility: visible; animation-name: fadeInUp; width: 100%;" style="color:#EBDEBE"> | ||
| + | <h4 style="color:#EBDEBE">Project Description</h4> | ||
| + | <p>Each year on Earth, individuals receive 2.4 mSv of ionizing radiation (IR), which is easily tolerated by our cells. In space however, without the protection of the magnetosphere, astronauts are exposed to high levels of IR in the range of 50 to 2000 mSv which causes the accumulation of deleterious double strand breaks in DNA. Despite current research into methods of IR protection, many solutions such as radiation shield coating are expensive. Biological solutions such as the use of radioprotectors are also subjected to the sinusoidal pharmacokinetic problem resulting in the need for constant administration and the accumulation of waste. </p> <p> | ||
| + | |||
| + | Certain naturally-occuring proteins and peptides, such as the modified Bowman-Birk Inhibitor (mBBI), have been found to confer protection against DNA damage in cells exposed to ionizing radiation. Previous studies have shown that BBI increases the survival rate of cells significantly when irradiated, by augmenting endogenous DNA repair mechanisms. </p><p> | ||
| + | |||
| + | To solve the problem of creating a cost effective, continuous delivery system for IR protection, we have designed a transdermal patch for the delivery of mBBI through the skin. The patch hosts recombinant Bacillus subtilis that expresses a mBBI gene tagged with a transdermal tag that allows the peptide to travel through the skin layers, and into the bloodstream for dispersal throughout the body. Using B. subtilis for the production of mBBI allows for constant delivery bypassing the sinusoidal pharmacokinetic problem. Its long term, continuous delivery will also create a cost effective solution. Ultimately our transdermal delivery system allows for the administration biotherapeutics within an efficient and practical system. | ||
| + | |||
| + | |||
| + | </p> | ||
| + | </div> | ||
| + | </div> | ||
| + | </div> | ||
| + | </div> | ||
| + | </div> | ||
| + | <!-- BEGIN: CONTENT/FEATURES/FEATURES-1 --> | ||
| + | </div> | ||
| + | |||
| + | |||
| + | |||
| + | |||
| + | <div class="c-content-box c-size-md c-bg-darkblue c-no-bottom-padding"> | ||
<div class="container"> | <div class="container"> | ||
<div class="c-content-product-1 c-opt-1"> | <div class="c-content-product-1 c-opt-1"> | ||
| Line 709: | Line 743: | ||
<script src="../assets/global/plugins/excanvas.min.js"></script> | <script src="../assets/global/plugins/excanvas.min.js"></script> | ||
<![endif]--> | <![endif]--> | ||
| − | |||
| − | |||
| − | |||
<!-- END: CORE PLUGINS --> | <!-- END: CORE PLUGINS --> | ||
<!-- BEGIN: LAYOUT PLUGINS --> | <!-- BEGIN: LAYOUT PLUGINS --> | ||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
<script> | <script> | ||
$(document).ready(function() { | $(document).ready(function() { | ||
Latest revision as of 21:08, 27 June 2016
Our Project
-
Project Description
Each year on Earth, individuals receive 2.4 mSv of ionizing radiation (IR), which is easily tolerated by our cells. In space however, without the protection of the magnetosphere, astronauts are exposed to high levels of IR in the range of 50 to 2000 mSv which causes the accumulation of deleterious double strand breaks in DNA. Despite current research into methods of IR protection, many solutions such as radiation shield coating are expensive. Biological solutions such as the use of radioprotectors are also subjected to the sinusoidal pharmacokinetic problem resulting in the need for constant administration and the accumulation of waste.
Certain naturally-occuring proteins and peptides, such as the modified Bowman-Birk Inhibitor (mBBI), have been found to confer protection against DNA damage in cells exposed to ionizing radiation. Previous studies have shown that BBI increases the survival rate of cells significantly when irradiated, by augmenting endogenous DNA repair mechanisms.
To solve the problem of creating a cost effective, continuous delivery system for IR protection, we have designed a transdermal patch for the delivery of mBBI through the skin. The patch hosts recombinant Bacillus subtilis that expresses a mBBI gene tagged with a transdermal tag that allows the peptide to travel through the skin layers, and into the bloodstream for dispersal throughout the body. Using B. subtilis for the production of mBBI allows for constant delivery bypassing the sinusoidal pharmacokinetic problem. Its long term, continuous delivery will also create a cost effective solution. Ultimately our transdermal delivery system allows for the administration biotherapeutics within an efficient and practical system.
Our Project
-
Radiation
Lorem ipsum dolor sit amet consectetuer adipiscing elit sed diam nonummy nibh euismod
-
Access to Nutrients
Lorem ipsum dolor sit amet consectetuer adipiscing elit sed diam nonummy nibh euismod
-
Resource Limitations
Lorem ipsum dolor sit amet consectetuer adipiscing elit sed diam nonummy nibh euismod
-
Reusable Framework
Lorem ipsum dolor sit amet consectetuer adipiscing elit sed diam nonummy nibh euismod
Escherichia coli
Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed elit diam nonummy nibh euismod tincidunt ut laoreet dolore magna aluam erat volutpat. Ut wisi enim ad minim veniam quis nostrud exerci et tation diam nisl ut aliquip ex ea commodo consequat euismod tincidunt ut laoreet dolore magna aluam.
Basillus Subtilis
Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed elit diam nonummy nibh euismod tincidunt ut laoreet dolore magna aluam erat volutpat. Ut wisi enim ad minim veniam quis nostrud exerci et tation diam nisl ut aliquip ex ea commodo consequat euismod tincidunt ut laoreet dolore magna aluam.
Deinococcus radiodurans
Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed elit diam nonummy nibh euismod tincidunt ut laoreet dolore magna aluam erat volutpat. Ut wisi enim ad minim veniam quis nostrud exerci et tation diam nisl ut aliquip ex ea commodo consequat euismod tincidunt ut laoreet dolore magna aluam.
Our Project
About us
Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed elit diam nonummy nibh euismod tincidunt ut laoreet dolore magna aluam erat volutpat. Ut wisi enim ad minim veniam quis nostrud exerci et tation diam nisl ut aliquip ex ea commodo consequat euismod tincunt ut laoreet dolore magna aluam
- Lit af project
- Sick lab
- Huge fam
Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed elit diam nonummy nibh euismod tincidunt ut laoreet dolore.
Our Sponsors
