Difference between revisions of "Team:Jilin China/Description"
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Revision as of 07:14, 14 October 2016
Background
Although trying very hard by many brilliant scientists and doctors for decades, the therapies of cancer were still painful and ineffective for patients in many cases. Among various kinds of tumors, solid tumors, which are also the subjects of our projects, have it own features on destroying people’s health. Solid tumors are visible lumps that can be detected by clinical examination. The vessels inside solid tumors are abnormal structurally and functionally, thus cannot provide adequate oxygen and nutrients. The partial pressure of oxygen in normal tissues is 3.21-8.8kPa, while in the solid tumor the pressure is 1.33-4kPa or less than 0.33kPa. Therefore, the solid tumor cells easily undergo necrosis inside, forming regions with necrosis and lack of oxygen, acute or chronic, weakening the effect of radiotherapy and chemotherapy, while the residual tumor cells become more invasive and metastatic. According to many clinical surveys, solid tumor constitutes the most severe type of cancers that threaten human health.
Background
Synthetic biology provides scientists with a novel approach to tackle with cancer cells, which is to use the modified bacteria to express toxic protein as drugs to kill cancer cells yet do no significantly affect the survival of normal cells. The work of Jeff, published in 2016, proved the validity and feasibility of this approach. In addition to this pioneer work, many kinds of bacteria are regarded safe in vivo. These bacteria show no immunogenic to human bodies, and they could be controlled by the recombinant plasmids. Besides, the growth and reproduction of anaerobic bacteria predominantly happens in hypoxia regions, which coincides with the feature of solid tumors. We took advantage of all these previous work and planned our own project accordingly.
PART 2
PART 3
PART 4
