Difference between revisions of "Team:Edinburgh UG"

Revision as of 14:47, 30 June 2016

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BabblED

The University of Edinburgh Undergraduate iGEM Team 2016 presents:

The next generation of information storage

By 2040, we will run out of the materials needed to store digital data.

If this happens, there will be no capacity for Twitter, Facebook or iGEM to function online. Last year, data centres worldwide used more electricity than the entire United Kingdom. By 2020, it will cost more than $13.7 billion to power data centres per year.

We have a solution.

DNA Text Encoding

Density

Longevity

Affordability

Modularity

DNA has 1000 times greater storage density than flash memory

DNA can last for thousands of years without consuming resources; modern hard drives can only last 50

All our encoding programmes are open source and initial synthesis of the lexicon is done for you providing significant cost reductions on existing methods

Assembly of our BabbleBricks is unrestricted and completely customisable

Abstract

The last decade has seen an exponential increase in data and information generation, creating a storage demand that will soon outweigh supply. By 2040, global data storage demand will reach 3×10^24 (3 million billion billion) bits^1.. Considering the amount of energy required to run a data centre (about 2% of global energy consumption^2.) and the limited supply of raw materials like silicon for manufacturing memory devices, it is clear that novel storage methods are of the utmost importance in meeting demand and providing a sustainable, long term solution to the data storage problem. The University of Edinburgh 2016 undergraduate iGEM team held these considerations in mind when we set out to create a new DNA-based storage system.
Over the course of weeks 1 and 2 our team explored and researched ideas for a project utilising DNA as an information storage device. Our brainstorming process evolved through discussions about the advantages and disadvantages of DNA synthesis and encoding digital information into nucleotide sequences. Major points of debate were cost, fidelity and efficiency of data storage. Following some constructive feedback from our supervisors, our team focused on developing a method that is accessible, sustainable and fits the iGEM format.

Medal Criteria

We've created a wiki page dedicated to outlining how we fulfilled each of the gold medal requirements.

Our project, given the name BabblED, is based on a simple idea: develop a modular system for encoding text, or any other unit of information, into DNA. We will prove the validity of our concept by encoding Ogden’s Basic English (a collection of 850-1,000 words that can be used to express most concepts in the English language). Each encoded word sequence, termed a BabbleBrick, will be stored in a different PhytoBrick. Sentence assembly and directionality is ensured with stepwise addition of ‘DNA words’ that have alternating types of sticky ends; this also prevents repeats and minimizes the occurrence of missing words. The whole sentence construct can be melted off for easy retrieval and assembled back into a PhytoBrick for storage. Since the value that is assigned to each BabbleBrick is arbitrary, each one can be reused with any library or language. In this way, our encoding and assembly method can be optimized for many types of data. Furthermore, using tools such as checksums, optimal rectangular codes and, when appropriate, natural language processing techniques, we are able to ensure that each BabbleBrick sentence can be decoded with 100% accuracy.
As of week 4, we have developed the computer program that converts our vocabulary to BabbleBrick sequences. We have designed the DNA sequences for error-correcting codes and researched the benefits and potential ways to utilize encryption in our method. We are in the process of ordering our first BabbleBricks in the form of gBlocks from IDT and testing our assembly method for efficiency. We have commenced the 2016 Interlab study and are pursuing another exciting project on bacterial growth-based logic. We have already had some fascinating discussions with data specialists and librarians; their feedback and expertise are vital to how we are shaping our project. We have also been in touch with other iGEM teams, such as Newcastle and Dundee, and are hosting a Scottish team meet-up in the beginning of July.
References:
1.http://www.nature.com/nmat/journal/v15/n4/full/nmat4594.html#supplementary-information
2.http://www.greenpeace.org/international/Global/international/publications/climate/2011/Cool%20IT/dirty-data-report-greenpeace.pdf/

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-function CMSpecialEffectInstance(a,b){a.show=!0;a.menu=b;this.effect=b.cmEffect=a}CMSpecialEffectInstance.prototype.canShow=function(a){if(a){if(this.effect.show)return!1;this.effect.show=!0}else if(!this.effect.show)return!1;return!0};CMSpecialEffectInstance.prototype.canHide=function(a){var b=this.effect;if(a){if(!b.show)return!1;b.show=!1}else if(b.show)return!1;return!0};CMSpecialEffectInstance.prototype.startShowing=function(){this.effect.menu.style.visibility="visible"};
-CMSpecialEffectInstance.prototype.finishShowing=function(){};CMSpecialEffectInstance.prototype.finishHiding=function(){var a=this.effect.menu;a.style.visibility="hidden";a.style.top="0px";a.style.left="0px";a.cmEffect=null;a.cmOrient=null;this.effect.menu=null};
-function CMSlidingEffectInstance(a,b,c){this.base=new CMSpecialEffectInstance(this,a);a.style.overflow="visible";this.x=a.offsetLeft;this.y=a.offsetTop;"h"==b.charAt(0)?(this.slideOrient="h",this.slideDir=b.charAt(1)):(this.slideOrient="v",this.slideDir=b.charAt(2));this.speed=c;this.fullWidth=a.offsetWidth;this.fullHeight=a.offsetHeight;this.percent=0}
-CMSlidingEffectInstance.prototype.showEffect=function(a){this.base.canShow(a)&&(a=this.percent,"h"==this.slideOrient?this.slideMenuV():this.slideMenuH(),0==a&&this.base.startShowing(),100>a?(this.percent+=this.speed,cmTimeEffect(this.menu.id,this.show,10)):this.show&&this.base.finishShowing())};
-CMSlidingEffectInstance.prototype.hideEffect=function(a){this.base.canHide(a)&&(a=this.percent,"h"==this.slideOrient?this.slideMenuV():this.slideMenuH(),0<a?(this.percent-=this.speed,cmTimeEffect(this.menu.id,this.show,10)):this.show||(this.menu.style.clip="auto",this.base.finishHiding()))};
-CMSlidingEffectInstance.prototype.slideMenuH=function(){var a=this.percent;0>a&&(a=0);100<a&&(a=100);var b=this.fullWidth,c=this.fullHeight,d=this.x,a=a*b/100,e=this.menu;"l"==this.slideDir?(e.style.left=d+b-a+"px",e.style.clip="rect(0px "+a+"px "+c+"px 0px)"):(e.style.left=d-b+a+"px",e.style.clip="rect(0px "+b+"px "+c+"px "+(b-a)+"px)")};
-CMSlidingEffectInstance.prototype.slideMenuV=function(){var a=this.percent;0>a&&(a=0);100<a&&(a=100);var b=this.fullWidth,c=this.fullHeight,d=this.y,a=a*c/100,e=this.menu;"b"==this.slideDir?(e.style.top=d-c+a+"px",e.style.clip="rect("+(c-a)+"px "+b+"px "+c+"px 0px)"):(e.style.top=d+c-a+"px",e.style.clip="rect(0px "+b+"px "+a+"px 0px)")};function CMSlidingEffect(a){a?0>=a?a=10:100<=a&&(a=100):a=10;this.speed=a}
-CMSlidingEffect.prototype.getInstance=function(a,b){return new CMSlidingEffectInstance(a,b,this.speed)};function CMFadingEffectInstance(a,b,c){this.base=new CMSpecialEffectInstance(this,a);a.style.overflow="visible";this.showSpeed=b;this.hideSpeed=c;this.opacity=0}
-CMFadingEffectInstance.prototype.showEffect=function(a){if(this.base.canShow(a)){a=this.menu;var b=this.opacity;this.setOpacity();0==b&&this.base.startShowing();100>b?(this.opacity+=10,cmTimeEffect(a.id,this.show,this.showSpeed)):this.show&&this.base.finishShowing()}};CMFadingEffectInstance.prototype.hideEffect=function(a){this.base.canHide(a)&&(a=this.menu,this.setOpacity(),0<this.opacity?(this.opacity-=10,cmTimeEffect(a.id,this.show,this.hideSpeed)):this.show||this.base.finishHiding())};
-CMFadingEffectInstance.prototype.setOpacity=function(){this.menu.style.opacity=this.opacity/100};function CMFadingEffect(a,b){this.showSpeed=a;this.hideSpeed=b}CMFadingEffect.prototype.getInstance=function(a,b){return new CMFadingEffectInstance(a,this.showSpeed,this.hideSpeed)};
-</script>
-<style type="text/css">
-/*
-a
-{
-   color: #0000FF;
-   text-decoration: underline;
-}
-a:visited
-{
-   color: #800080;
-}
-a:active
-{
-   color: #FF0000;
-}
-a:hover
-{
-   color: #0000FF;
-   text-decoration: underline;
-}
-h1
-{
-   font-family: Arial;
-   font-weight: bold;
-   font-size: 32px;
-   font-style: normal;
-   text-decoration: none;
-   color: #000000;
-   background-color: transparent;
-   margin: 0px 0px 0px 0px;
-   padding: 0px 0px 0px 0px;
-   display: inline;
-}
-h2
-{
-   font-family: Arial;
-   font-weight: bold;
-   font-size: 27px;
-   font-style: normal;
-   text-decoration: none;
-   color: #000000;
-   background-color: transparent;
-   margin: 0px 0px 0px 0px;
-   padding: 0px 0px 0px 0px;
-   display: inline;
-}
-h3
-{
-   font-family: Arial;
-   font-weight: normal;
-   font-size: 24px;
-   font-style: normal;
-   text-decoration: none;
-   color: #000000;
-   background-color: transparent;
-   margin: 0px 0px 0px 0px;
-   padding: 0px 0px 0px 0px;
-   display: inline;
-}
-h4
-{
-   font-family: Arial;
-   font-weight: normal;
-   font-size: 21px;
-   font-style: italic;
-   text-decoration: none;
-   color: #000000;
-   background-color: transparent;
-   margin: 0px 0px 0px 0px;
-   padding: 0px 0px 0px 0px;
-   display: inline;
-}
-h5
-{
-   font-family: Arial;
-   font-weight: normal;
-   font-size: 19px;
-   font-style: normal;
-   text-decoration: none;
-   color: #000000;
-   background-color: transparent;
-   margin: 0px 0px 0px 0px;
-   padding: 0px 0px 0px 0px;
-   display: inline;
-}
-h6
-{
-   font-family: Arial;
-   font-weight: normal;
-   font-size: 16px;
-   font-style: normal;
-   text-decoration: none;
-   color: #000000;
-   background-color: transparent;
-   margin: 0px 0px 0px 0px;
-   padding: 0px 0px 0px 0px;
-   display: inline;
-}
-.CustomStyle
-{
-   font-family: "Courier New";
-   font-weight: bold;
-   font-size: 16px;
-   font-style: normal;
-   text-decoration: none;
-   color: #000080;
-   background-color: transparent;
-}
-</style>
 <style type="text/css">
 body
@@ Line 210: / Line 26: @@
     height: 100%;
 }
 #wb_Text1
 {
     background-color: transparent;
@@ Line 223: / Line 39: @@
     text-align: center;
 }
 #wb_Text2
 {
     background-color: transparent;
@@ Line 236: / Line 52: @@
     text-align: center;
 }
 #wb_Text3
 {
     background-color: transparent;
@@ Line 249: / Line 65: @@
     text-align: center;
 }
 #wb_Text4
 {
     background-color: transparent;
@@ Line 262: / Line 78: @@
     text-align: left;
 }
 #wb_Text5
 {
     background-color: transparent;
@@ Line 293: / Line 109: @@
     background-image: none;
     color: #101010;
-    font-family: "Courier New";
+    font-family: Verdana;
     font-weight: normal;
     font-size: 13px;
@@ Line 303: / Line 119: @@
     width: 1407px;
 }
 #wb_Text6
 {
     background-color: transparent;
@@ Line 361: / Line 177: @@
     height: 100%;
 }
 #wb_Text7
 {
     background-color: transparent;
@@ Line 374: / Line 190: @@
     text-align: left;
 }
 #wb_Text8
 {
     background-color: transparent;
@@ Line 387: / Line 203: @@
     text-align: center;
 }
 #wb_Text9
 {
     background-color: transparent;
@@ Line 400: / Line 216: @@
     text-align: center;
 }
 #wb_Text10
 {
     background-color: transparent;
@@ Line 413: / Line 229: @@
     text-align: center;
 }
 #wb_Text11
 {
     background-color: transparent;
@@ Line 426: / Line 242: @@
     text-align: center;
 }
 #wb_Text12
 {
     background-color: transparent;
@@ Line 439: / Line 255: @@
     text-align: center;
 }
 #wb_Text13
 {
     background-color: transparent;
@@ Line 452: / Line 268: @@
     text-align: center;
 }
 #wb_Text14
 {
     background-color: transparent;
@@ Line 465: / Line 281: @@
     text-align: center;
 }
 #wb_Text15
 {
     background-color: transparent;
@@ Line 493: / Line 309: @@
     height: 100%;
 }
 #wb_Text16
 {
     background-color: transparent;
@@ Line 506: / Line 322: @@
     text-align: left;
 }
 #wb_Text17
 {
     background-color: transparent;
@@ Line 518: / Line 334: @@
 {
     text-align: left;
-}
+    white-space: nowrap;
-#Button2
-{
-    border: 1px #000000 solid;
-   -moz-border-radius: 4px;
-   -webkit-border-radius: 4px;
-   border-radius: 4px;
-   background-color: transparent;
-   background-image: none;
-   color: #101010;
-   font-family: "Courier New";
-   font-weight: normal;
-   font-size: 13px;
 }
 #Line3
@@ Line 553: / Line 357: @@
     height: 100%;
 }
 #wb_Text18
 {
     background-color: transparent;
@@ Line 566: / Line 370: @@
     text-align: left;
 }
 #wb_Text19
 {
     background-color: transparent;
@@ Line 588: / Line 392: @@
     background-image: none;
     color: #101010;
-    font-family: "Courier New";
+    font-family: Verdana;
     font-weight: normal;
     font-size: 13px;
@@ Line 601: / Line 405: @@
     background-image: none;
     color: #101010;
-    font-family: "Courier New";
+    font-family: Verdana;
     font-weight: normal;
     font-size: 13px;
 }
-#MenuBar1
+#wb_Text20
 {
     background-color: transparent;
-   border: 0px solid #AED0EA;
+    background-image: none;
-}
+    border: 0px #000000 solid;
-.MenuBar1SubMenu
-{
-    background-color: transparent;
-    border: 1px solid #9199A4;
-   position:	absolute;
-   visibility: hidden;
-   overflow: visible;
-   z-index: 100;
-}
-.MenuBar1SubMenuTable
-{
-   cursor: default;
-   border: 0;
     padding: 0;
-}
-.MenuBar1SubMenuTable tr
-{
     margin: 0;
-   padding: 0;
-}
-.MenuBar1Menu
-{
-   background-color: transparent;
-   margin: 0px 0 0px 0px;
-   padding: 0;
-}
-.MenuBar1MenuOuter
-{
-   background-color: transparent;
-   border: 0px solid #AED0EA;
-}
-.MenuBar1Menu tr
-{
-   margin: 0;
-   padding: 0;
-}
-.MenuBar1MainItem .MenuBar1MainItemLeft,
-.MenuBar1MainItem .MenuBar1MainFolderLeft
-{
-   width: 0px;
-   cursor: pointer;
-   border-width: 0;
-   text-align: center;
-   padding: 10px 0px 10px 0px;
-   font-size: 1px;
-}
-.MenuBar1MainItem .MenuBar1MainItemText,
-.MenuBar1MainItem .MenuBar1MainItemText a,
-.MenuBar1MainItem .MenuBar1MainFolderText,
-.MenuBar1MainItem .MenuBar1MainFolderText a
-{
-   background-color: transparent;
-   background-image: url(https://static.igem.org/mediawiki/2016/d/d5/EdiGEM16UGhome_menuBar1_bkgrnd1.png);
-   background-repeat: repeat-x;
-   background-position: left top;
-   color: #FFFFFF;
-   font-size: 13px;
-   font-family: Arial;
-   font-weight: normal;
-   line-height: 16px;
     text-align: left;
-   text-decoration: none;
-   white-space: nowrap;
-   margin: 0;
-   cursor: pointer;
-   border-bottom: 0px solid #9199A4;
-   border-right: 0px solid #9199A4;
-   border-top: 0px solid #9199A4;
-   border-left: 0px solid #9199A4;
-   padding: 11px 11px 11px 11px;
-   vertical-align: middle;
 }
-.MenuBar1MainItem .MenuBar1MainItemRight,
+#wb_Text20 div
-.MenuBar1MainItem .MenuBar1MainFolderRight
 {
-   width: 0px;
-   cursor: pointer;
-   border-width: 0;
-   padding: 10px 0px 10px 0px;
-   font-size: 1px;
-}
-.MenuBar1MainItemHover .MenuBar1MainItemLeft,
-.MenuBar1MainItemActive .MenuBar1MainItemLeft,
-.MenuBar1MainItemHover .MenuBar1MainFolderLeft,
-.MenuBar1MainItemActive .MenuBar1MainFolderLeft
-{
-   width: 0px;
-   cursor: pointer;
-   border-width: 0;
-   padding: 10px 0px 10px 0px;
-   font-size: 1px;
-}
-.MenuBar1MainItemHover .MenuBar1MainItemText,
-.MenuBar1MainItemActive .MenuBar1MainItemText,
-.MenuBar1MainItemHover .MenuBar1MainItemText a,
-.MenuBar1MainItemActive .MenuBar1MainItemText a,
-.MenuBar1MainItemHover .MenuBar1MainFolderText,
-.MenuBar1MainItemActive .MenuBar1MainFolderText,
-.MenuBar1MainItemHover .MenuBar1MainFolderText a,
-.MenuBar1MainItemActive .MenuBar1MainFolderText a
-{
-   background-color: transparent;
-   background-image: url(https://static.igem.org/mediawiki/2016/7/70/EdiGEM16UGhome_menuBar1_bkgrnd4.png);
-   background-repeat: repeat-x;
-   background-position: left top;
-   color: #FFFFFF;
-   font-size: 13px;
-   font-family: Arial;
-   font-weight: normal;
-   line-height: 16px;
     text-align: left;
-   text-decoration: none;
     white-space: nowrap;
-   margin: 0;
-   cursor: pointer;
-   border-bottom: 1px solid #9199A4;
-   border-right: 1px solid #9199A4;
-   border-top: 1px solid #9199A4;
-   border-left: 1px solid #9199A4;
-   padding: 10px 10px 10px 10px;
-   vertical-align: middle;
-}
-.MenuBar1MainItemHover .MenuBar1MainItemRight,
-.MenuBar1MainItemActive .MenuBar1MainItemRight,
-.MenuBar1MainItemHover .MenuBar1MainFolderRight,
-.MenuBar1MainItemActive .MenuBar1MainFolderRight
-{
-   width: 0px;
-   cursor: pointer;
-   border-width: 0;
-   padding: 10px 0px 10px 0px;
-   font-size: 1px;
-}
-.MenuBar1MenuItem .MenuBar1MenuItemLeft,
-.MenuBar1MenuItem .MenuBar1MenuFolderLeft
-{
-   background-color: transparent;
-   background-image: url(https://static.igem.org/mediawiki/2016/9/90/EdiGEM16UGhome_menuBar1_bkgrnd12.png);
-   background-repeat: repeat-y;
-   background-position: left top;
-   width: 24px;
-   cursor: pointer;
-   border-bottom: 0px solid #FFBD69;
-   border-left: 0px solid #FFBD69;
-   border-top: 0px solid #FFBD69;
-   border-right: 0;
-   text-align: center;
-   padding: 11px 0px 11px 1px;
-   font-size: 1px;
-}
-.MenuBar1MenuItem .MenuBar1MenuItemText,
-.MenuBar1MenuItem .MenuBar1MenuItemText a,
-.MenuBar1MenuItem .MenuBar1MenuFolderText,
-.MenuBar1MenuItem .MenuBar1MenuFolderText a
-{
-   background-color: #FFFFFF;
-   color: #000000;
-   font-size: 13px;
-   font-family: Arial;
-   font-weight: normal;
-   line-height: 16px;
-   text-align: left;
-   text-decoration: none;
-   white-space: nowrap;
-   margin: 0;
-   cursor: pointer;
-   border-bottom: 0px solid #FFBD69;
-   border-top: 0px solid #FFBD69;
-   border-right: 0px solid #FFBD69;
-   border-left: 0px solid #FFBD69;
-   padding: 11px 10px 11px 10px;
-   vertical-align: middle;
-}
-.MenuBar1MenuItem .MenuBar1MenuItemRight,
-.MenuBar1MenuItem .MenuBar1MenuFolderRight
-{
-   background-color: #FFFFFF;
-   width: 10px;
-   cursor: pointer;
-   border-bottom: 0px solid #FFBD69;
-   border-right: 0px solid #FFBD69;
-   border-top: 0px solid #FFBD69;
-   border-left: 0;
-   padding: 11px 1px 11px 0px;
-   font-size: 1px;
-}
-.MenuBar1MenuItemHover .MenuBar1MenuItemLeft,
-.MenuBar1MenuItemActive .MenuBar1MenuItemLeft,
-.MenuBar1MenuItemHover .MenuBar1MenuFolderLeft,
-.MenuBar1MenuItemActive .MenuBar1MenuFolderLeft
-{
-   background-color: transparent;
-   background-image: url(https://static.igem.org/mediawiki/2016/e/ed/EdiGEM16UGhome_menuBar1_bkgrnd15.png);
-   background-repeat: repeat-y;
-   background-position: left top;
-   width: 24px;
-   cursor: pointer;
-   border-bottom: 1px solid #FFBD69;
-   border-left: 1px solid #FFBD69;
-   border-top: 1px solid #FFBD69;
-   border-right: 0;
-   padding: 10px 0px 10px 0px;
-   font-size: 1px;
-}
-.MenuBar1MenuItemHover .MenuBar1MenuItemText,
-.MenuBar1MenuItemActive .MenuBar1MenuItemText,
-.MenuBar1MenuItemHover .MenuBar1MenuItemText a,
-.MenuBar1MenuItemActive .MenuBar1MenuItemText a,
-.MenuBar1MenuItemHover .MenuBar1MenuFolderText,
-.MenuBar1MenuItemActive .MenuBar1MenuFolderText,
-.MenuBar1MenuItemHover .MenuBar1MenuFolderText a,
-.MenuBar1MenuItemActive .MenuBar1MenuFolderText a
-{
-   background-color: #FFE7A2;
-   color: #000000;
-   font-size: 13px;
-   font-family: Arial;
-   font-weight: normal;
-   line-height: 16px;
-   text-align: left;
-   text-decoration: none;
-   white-space: nowrap;
-   margin: 0;
-   cursor: pointer;
-   border-bottom: 1px solid #FFBD69;
-   border-top: 1px solid #FFBD69;
-   border-right: 0px solid #FFBD69;
-   border-left: 0px solid #FFBD69;
-   padding: 10px 10px 10px 10px;
-   vertical-align: middle;
-}
-.MenuBar1MenuItemHover .MenuBar1MenuItemRight,
-.MenuBar1MenuItemActive .MenuBar1MenuItemRight,
-.MenuBar1MenuItemHover .MenuBar1MenuFolderRight,
-.MenuBar1MenuItemActive .MenuBar1MenuFolderRight
-{
-   background-color: #FFE7A2;
-   width: 10px;
-   cursor: pointer;
-   border-bottom: 1px solid #FFBD69;
-   border-right: 1px solid #FFBD69;
-   border-top: 1px solid #FFBD69;
-   border-left: 0;
-   padding: 10px 0px 10px 0px;
-   font-size: 1px;
-}
-.MenuBar1MenuItem .MenuBar1MenuFolderRight
-{
-   background-image: url(https://static.igem.org/mediawiki/2016/0/07/EdiGEM16UGhome_menuBar1_bkgrnd18.png);
-   background-position: left center;
-   background-repeat: no-repeat;
-}
-.MenuBar1MenuItemHover .MenuBar1MenuFolderRight,
-.MenuBar1MenuItemActive .MenuBar1MenuFolderRight
-{
-   background-image: url(https://static.igem.org/mediawiki/2016/5/5d/EdiGEM16UGhome_menuBar1_bkgrnd20.png);
-   background-position: left center;
-   background-repeat: no-repeat;
-}
-.MenuBar1SubMenu td,
-.MenuBar1Menu td,
-.MenuBar1Menu tr
-{
-   vertical-align: middle;
-}
-.MenuBar1MenuSplitText div
-{
-   height: 1px;
-   padding: 0;
-   background-color: #FFFFFF;
-   overflow: hidden;
-}
-.MenuBar1MenuItem .MenuBar1MenuSplitLeft
-{
-   background-color: transparent;
-   background-image: url(images/ediGEM16UGhome_MenuBar1_bkgrnd12.png);
-   background-repeat: repeat-y;
-   background-position: left top;
-   height: 21px;
-   padding: 0px 0px 0px 0px;
-}
-.MenuBar1MenuItem .MenuBar1MenuSplitText
-{
-   background-color: #FFFFFF;
-   height: 21px;
-   padding: 0px 6px 0px 6px;
-}
-.MenuBar1MenuItem .MenuBar1MenuSplitRight
-{
-   background-color: #FFFFFF;
-   height: 21px;
-   padding: 0px 0px 0px 0px;
-}
-.MenuBar1MainSplitText div
-{
-   background-color: #FFFFFF;
-   height: 1px;
-   padding: 0;
-   overflow: hidden;
-}
-.MenuBar1MainItem .MenuBar1MainSplitLeft
-{
-   height: 23px;
-   padding: 0px 0px 0px 0px;
-}
-.MenuBar1MainItem .MenuBar1MainSplitText
-{
-   background-color: transparent;
-   background-image: url(images/ediGEM16UGhome_menuBar1_bkgrnd1.png);
-   background-repeat: repeat-x;
-   background-position: left top;
-   height: 23px;
-   padding: 0px 0px 0px 0px;
-}
-.MenuBar1MainItem .MenuBar1MainSplitRight
-{
-   height: 23px;
-   padding: 0px 0px 0px 0px;
-}
-.MenuBar1MainItem
-{
-   vertical-align: middle;
-}
-.MenuBar1HorizontalSplit
-{
-   border-right: 0 solid #8080FF;
-   border-left: 0 solid #8080FF;
-   width: 27px;
-   background-color: transparent;
-   background-image: url(images/ediGEM16UGhome_menuBar1_bkgrnd1.png);
-   background-repeat: repeat-x;
-   background-position: left top;
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-<span style="color:#000000;font-family:'Courier New';font-size:75px;">BabblED</span></div>
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-<span style="color:#000000;font-family:'Courier New';font-size:17px;">The University of Edinburgh Undergraduate iGEM Team 2016 presents:</span></div>
+<span style="color:#000000;font-family:Verdana;font-size:17px;">The University of Edinburgh Undergraduate iGEM Team 2016 presents:</span></div>
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-<span style="color:#000000;font-family:'Courier New';font-size:17px;">The next generation of information storage</span></div>
+<span style="color:#000000;font-family:Verdana;font-size:17px;">The next generation of information storage</span></div>
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-<span style="color:#000000;font-family:'Courier New';font-size:37px;">By 2040, we will run out of the materials needed to store digital data.</span></div>
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-<span style="color:#000000;font-family:'Courier New';font-size:21px;">If this happens, there will be no capacity for Twitter, Facebook or iGEM to function online. Last year, data centres worldwide used more electricity than the entire United Kingdom. By 2020, it will cost more than $13.7 billion to power data centres per year.</span><span style="color:#000000;font-family:'Courier New';font-size:16px;"> </span></div>
+<span style="color:#000000;font-family:Verdana;font-size:21px;">If this happens, there will be no capacity for Twitter, Facebook or iGEM to function online. Last year, data centres worldwide used more electricity than the entire United Kingdom. By 2020, it will cost more than $13.7 billion to power data centres per year.</span><span style="color:#000000;font-family:'Courier New';font-size:16px;"> </span></div>
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+<span style="color:#000000;font-family:Verdana;font-size:32px;">We have a solution.</span><span style="color:#000000;font-family:Verdana;font-size:37px;"><br></span><span style="color:#000000;font-family:'Courier New';font-size:48px;"> </span></div>
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-<span style="color:#000000;font-family:'Courier New';font-size:17px;">DNA has 1000 times greater storage density than flash memory</span></div>
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-<span style="color:#000000;font-family:'Courier New';font-size:17px;">All our encoding programmes are open source and initial synthesis of the lexicon is done for you providing significant cost reductions on existing methods</span></div>
+<span style="color:#000000;font-family:Verdana;font-size:17px;">All our encoding programmes are open source and initial synthesis of the lexicon is done for you providing significant cost reductions on existing methods</span></div>
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-<span style="color:#000000;font-family:'Courier New';font-size:32px;">Project Description</span></div>
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-<span style="color:#000000;font-family:'Courier New';font-size:17px;">The last decade has seen an exponential increase in data and information generation, creating a storage demand that will soon outweigh supply. By 2040, global data storage demand will reach 3×10^24 (3 million billion billion) bits1.. Considering the amount of energy required to run a data centre (about 2% of global energy consumption2.) and the limited supply of raw materials like silicon for manufacturing memory devices, it is clear that novel storage methods are of the utmost importance in meeting demand and providing a sustainable, long term solution to the data storage problem. The University of Edinburgh 2016 undergraduate iGEM team held these considerations in mind when we set out to create a new DNA-based storage system.
+<span style="color:#000000;font-family:Verdana;font-size:16px;line-height:19px;">The last decade has seen an exponential increase in data and information generation, creating a storage demand that will soon outweigh supply. By 2040, global data storage demand will reach 3×10^24 (3 million billion billion) bits<sup>1.</sup>. Considering the amount of energy required to run a data centre (about 2% of global energy consumption<sup>2.</sup>) and the limited supply of raw materials like silicon for manufacturing memory devices, it is clear that novel storage methods are of the utmost importance in meeting demand and providing a sustainable, long term solution to the data storage&nbsp; problem. The University of Edinburgh 2016 undergraduate iGEM team held these considerations in mind when we set out to create a new DNA-based storage system. <br>Over the course of weeks 1 and 2 our team explored and researched ideas for a project utilising DNA as an information storage device. Our brainstorming process evolved through discussions about the advantages and disadvantages of DNA synthesis and encoding digital information into nucleotide sequences. Major points of debate were cost, fidelity and efficiency of data storage. Following some constructive feedback from our supervisors, our team focused on developing a method that is accessible, sustainable and fits the iGEM format. <br></span></div>
-Over the course of weeks 1 and 2 our team explored and researched ideas for a project utilising DNA as an information storage device. Our brainstorming process evolved through discussions about the advantages and disadvantages of DNA synthesis and encoding digital information into nucleotide sequences. Major points of debate were cost, fidelity and efficiency of data storage. Following some constructive feedback from our supervisors, our team focused on developing a method that is accessible, sustainable and fits the iGEM format.
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-Our project, given the name BabblED, is based on a simple idea: develop a modular system for encoding text, or any other unit of information, into DNA. We will prove the validity of our concept by encoding Ogden’s Basic English (a collection of 850-1,000 words that can be used to express most concepts in the English language). Each encoded word sequence, termed a BabbleBrick, will be stored in a different PhytoBrick. Sentence assembly and directionality is ensured with stepwise addition of ‘DNA words’ that have alternating types of sticky ends; this also prevents repeats and minimizes the occurrence of missing words. The whole sentence construct can be melted off for easy retrieval and assembled back into a PhytoBrick for storage. Since the value that is assigned to each BabbleBrick is arbitrary, each one can be reused with any library or language. In this way, our encoding and assembly method can be optimized for many types of data. Furthermore, using tools such as checksums, optimal rectangular codes and, when appropriate, natural language processing techniques, we are able to ensure that each BabbleBrick sentence can be decoded with 100% accuracy.
-As of week 4, we have developed the computer program that converts our vocabulary to BabbleBrick sequences. We have designed the DNA sequences for error-correcting codes and researched the benefits and potential ways to utilize encryption in our method. We are in the process of ordering our first BabbleBricks in the form of gBlocks from IDT and testing our assembly method for efficiency. We have commenced the 2016 Interlab study and are pursuing another exciting project on bacterial growth-based logic. We have already had some fascinating discussions with data specialists and librarians; their feedback and expertise are vital to how we are shaping our project. We have also been in touch with other iGEM teams, such as Newcastle and Dundee, and are hosting a Scottish team meet-up in the beginning of July.
-References:
-.http://www.nature.com/nmat/journal/v15/n4/full/nmat4594.html#supplementary-information
-.http://www.greenpeace.org/international/Global/international/publications/climate/2011/Cool%20IT/dirty-data-report-greenpeace.pdf/ </span></div>
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+<span style="color:#000000;font-family:Verdana;font-size:16px;line-height:19px;">Our project, given the name <strong>BabblED</strong>, is based on a simple idea: develop a modular system for encoding text, or any other unit of information, into DNA. We will prove the validity of our concept by encoding Ogden’s Basic English (a collection of 850-1,000 words that can be used to express most concepts in the English language). Each encoded word sequence, termed a BabbleBrick, will be stored in a different PhytoBrick. Sentence assembly and directionality is ensured with stepwise addition of ‘DNA words’ that have alternating types of sticky ends; this also prevents repeats and minimizes the occurrence of missing words. The whole sentence construct can be melted off for easy retrieval and assembled back into a PhytoBrick for storage. Since the value that is assigned to each <strong>BabbleBrick </strong>is arbitrary, each one can be reused with any library or language. In this way, our encoding and assembly method can be optimized for many types of data. Furthermore, using tools such as checksums, optimal rectangular codes and, when appropriate, natural language processing techniques, we are able to ensure that each <strong>BabbleBrick</strong> sentence can be decoded with 100% accuracy. <br>As of week 4, we have developed the computer program that converts our vocabulary to BabbleBrick sequences. We have designed the DNA sequences for error-correcting codes and researched the benefits and potential ways to utilize encryption in our method. We are in the process of ordering our first <strong>BabbleBricks</strong> in the form of gBlocks from IDT and testing our assembly method for efficiency. We have commenced the 2016 Interlab study and are pursuing another exciting project on bacterial growth-based logic. We have already had some fascinating discussions with data specialists and librarians; their feedback and expertise are vital to how we are shaping our project. We have also been in touch with other iGEM teams, such as Newcastle and Dundee, and are hosting a Scottish team meet-up in the beginning of July. <br>References:<br>1.http://www.nature.com/nmat/journal/v15/n4/full/nmat4594.html#supplementary-information<br>2.http://www.greenpeace.org/international/Global/international/publications/climate/2011/Cool%20IT/dirty-data-report-greenpeace.pdf/ <br></span><span style="color:#000000;font-family:Verdana;font-size:13px;line-height:18px;"><br></span></div>
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-<li><span></span><span>Description</span></li>
-<li><span></span><span>Design</span></li>
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-<li><span></span><span>Proof&nbsp;of&nbsp;Concept</span></li>
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-                                       '<td class="MenuBar1MenuSplitRight"><div></div></td>'];
-var cmMenuBar1MainVSplit = [_cmNoClick, '<div><table width="27" cellspacing="0"><tr><td class="MenuBar1HorizontalSplit">|</td></tr></table></div>'];
-var cmMenuBar1MainHSplit = [_cmNoClick, '<td colspan="3" class="MenuBar1MainSplitText"><div></div></td>'];
-cmDrawFromText('MenuBar1', 'hbr', cmMenuBar1, 'MenuBar1');
-</script>
-</div>
 </body>
 </html>
-*/