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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Description">Description</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Proof">Results</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Demonstrate">Demonstrate</a></li>
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− | <a href="mailto:igem@hhu.de><?xml version="1.0" ?><!DOCTYPE svg PUBLIC '-//W3C//DTD SVG 1.1//EN' 'http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd'><svg id="Layer_1" version="1.1" viewBox="0 0 512 512" class="social" style="width:10%; margin-top:10px;enable-background:new 0 0 76 76;" xml:space="preserve" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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− | <br>
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− | Heinrich-Heine University <br />
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− | Universitätsstraße 1 <br />
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− | 40225 Düsseldorf <br />
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− | Design by Marvin van Aalst <br>
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− | <div class="page">
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− | <div id="Navigation" class="navigation">
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− | <ul class="topnav">
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− | <li><a style="color: black;" href="https://2016.igem.org/Team:Duesseldorf">Home</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Description">Description</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Proof">Results</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Demonstrate">Demonstrate</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Future_Applications">Future Applications</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">Collaborations</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach">Outreach</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Education</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#IHP">Integrated Practices</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Hardware">Hardware</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Attributions">Attributions</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Safety">Safety</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Team">Team</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Parts">Parts</a></li>
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− | <li><a href="https://2016.igem.org/Team:Duesseldorf/Experiments">Experiments</a></li>
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− | </ul>
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− | </div>
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| | | |
− | <!-------------------------- ARTICLE ----------------------------> | + | <div class="sponsor" style="margin-top: 100px;"> |
− | <div class="article">
| + | <h3>Many thanks to our sponsors!</h3> |
| + | <table style="border: hidden" class="footer"> |
| + | <tr style="border: hidden"> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/f/f5/T--Duesseldorf--Bayer_Logo.svg" alt="Bayer"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/5/5b/T--Duesseldorf--Biozym_Logo.jpg" alt="Biozym"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/5/5b/Muc16_Sponsor_CarlRoth.png" alt="Carl Roth"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/7/7a/T--Duesseldorf--Ceplas_Logo.jpg" alt="Ceplas"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/5/55/T--Duesseldorf--Ella_Biotech_Logo.jpg" alt="Ella Biotech"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/f/fa/Eppendorf-Logo.svg.png" alt="Eppendorf"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/e/e6/Eurofins_logo.png" alt="Eurofins"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/9/95/GATC_Biotech_Logo.tiff.png" alt="GATC Biotech"></td> |
| + | </tr> |
| + | <tr style="border: hidden"> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/a/ad/Muc16_Sponsor_Geneious.png" alt="Geneious"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/5/56/T--Duesseldorf--HHU_Logo.gif" alt="HHU"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/6/67/Idt_logo.png" alt="IDT"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/b/b1/2000px-MLP-Logo.svg.png" alt="MLP"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/2/27/Muc16_Sponsor_NEB.png" alt="New England Biolabs"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/c/cf/2000px-Promega-Logo.svg.png" alt="Promega"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/9/9c/Qiagen_Logo.svg" alt="Qiagen"></td> |
| + | <td style="border: hidden"><img src="https://static.igem.org/mediawiki/2016/a/a1/Untitled.png" alt="Starlab"></td> |
| + | </tr> |
| + | </table> |
| | | |
− | <video id="Logo" src="https://static.igem.org/mediawiki/2016/b/b7/T--Duesseldorf--Logo-Animation.mov" autoplay="autoplay" width="100%;" height="auto;"></video> | + | </div> |
− | <h2>Imagine you turn the switch and the cancer is gone…</h2>
| + | </div> |
− | <p>
| + | |
− | Cancer is the second most common cause of death killing about 8.2 million people annually, which equals the total population of New York City.
| + | |
− | The global increase of cancer cases and the lack of highly specific therapies for various types of cancer states a clear message:<br>
| + | |
− | New approaches have to be found, which allow a level of precision in cancer treatment that has been long-awaited.
| + | |
− | <p>
| + | |
− | Our approach aims at achieving high spatiotemporal control of apoptosis in tumor cells by applying an optogenetic double-killswitch. This system combines clean removal of cancer cells through apoptosis with the accuracy of light-controlled optogenetics. We utilize two optogenetic proteins, to create a desperately needed holy grail of cancer therapy.<br>
| + | |
− | This is the goal of OPTOPTOSIS.
| + | |
− | </p>
| + | |
− | <h2 id="Medal_Criteria">Our Achievements</h2>
| + | |
− | <div class="w3-container" style="margin-bottom:50px;margin-top: 20px;">
| + | |
− | <div class="w3-row">
| + | |
− | <a href="javascript:void(0)" onclick="openrequirement(event, 'Bronze');">
| + | |
− | <span class="w3-third tablink w3-bottombar w3-hover-light-grey w3-padding" style="text-align:center;"><img src="https://static.igem.org/mediawiki/2016/a/a8/T--duesseldorf--medalbronze.PNG" style="width: 120px; height:120px; margin:auto;"></span>
| + | |
− | </a>
| + | |
− | <a href="javascript:void(0)" onclick="openrequirement(event, 'Silver');">
| + | |
− | <span class="w3-third tablink w3-bottombar w3-hover-light-grey w3-padding" style="text-align:center;"><img src="https://static.igem.org/mediawiki/2016/a/a0/T--duesseldorf--medalsilver.PNG" style="width: 120px; height:120px; margin:auto;"></span>
| + | |
− | </a>
| + | |
− | <a href="javascript:void(0)" onclick="openrequirement(event, 'Gold');">
| + | |
− | <span class="w3-third tablink w3-bottombar w3-hover-light-grey w3-padding" style="text-align:center;"><img src="https://static.igem.org/mediawiki/2016/8/86/T--duesseldorf--medalgold.PNG" style="width: 120px; height:120px; margin:auto;"></span>
| + | |
− | </a>
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− | </div>
| + | |
− | | + | |
− | | + | |
− | | + | |
− | <div id="Bronze" class="w3-container requirement" style="padding-top: 10px;">
| + | |
− | <h2>Bronze</h2>
| + | |
− | <h4>Register And Attend</h4>
| + | |
− | <ul>
| + | |
− | <li>our team was successfully registered and had the greatest summer ever</li>
| + | |
− | </ul>
| + | |
− | <h4><a href="https://2016.igem.org/Team:Duesseldorf/Attributions">Attribution</a></h4>
| + | |
− | <ul>
| + | |
− | <li>we created our own Wiki with clear attribution of each aspect of our project</li>
| + | |
− | </ul>
| + | |
− | | + | |
− | <h4>Deliverables </h4>
| + | |
− | | + | |
− | <ul>
| + | |
− | <li>The judging form and <a href="https://2016.igem.org/Team:Duesseldorf/Safety">safety form</a> was completed with great care</li>
| + | |
− | <li>we are very excited to present our poster and project talk at the Giant Jamboree</li>
| + | |
− | <li>we attributed and acknowledged all of the work done for our project on our Wiki page</li>
| + | |
− | <li>we documented and created Part pages for our Parts and submitted the DNA samples of our new Parts to the Registry</li>
| + | |
− | </ul>
| + | |
− | <h4>Part/Contribution</h4>
| + | |
− | we are proud of our new standard Biobrick Part and submitted <a href="https://2016.igem.org/Team:Duesseldorf/Parts">BBa_K1936000</a> to the iGEM Registry
| + | |
| | | |
| + | </div> |
| + | </div> |
| </div> | | </div> |
| | | |
− | <div id="Silver" class="w3-container requirement" style="padding-top: 10px;">
| + | <script> |
− | <h2>Silver</h2> | + | function openrequirement(evt, requirementName) { |
− | <h4><a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">Collaboration </a></h4>
| + | var i, x, tablinks; |
− | <ul>
| + | x = document.getElementsByClassName("requirement"); |
− | <li>we have great <a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">collaborations</a> with other teams and are really happy about our common success </li>
| + | for (i = 0; i < x.length; i++) { |
− | </ul>
| + | x[i].style.display = "none"; |
− | | + | } |
− | <h4><a href="https://2016.igem.org/Team:Duesseldorf/Parts">Validated Part / Validated Contribution</a></h4>
| + | tablinks = document.getElementsByClassName("tablink"); |
− | <ul> | + | for (i = 0; i < x.length; i++) { |
− | <li>we characterized <a href="https://2016.igem.org/Team:Duesseldorf/Parts">BBa_K1936001</a> </li>
| + | tablinks[i].className = tablinks[i].className.replace(" w3-border-green", ""); |
− | <li>this part was submitted to the iGEM registry and is experimentally validated</li>
| + | } |
− | </ul>
| + | document.getElementById(requirementName).style.display = "block"; |
− | | + | evt.currentTarget.firstElementChild.className += " w3-border-green"; |
− | <h4><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Human Practices</a></h4>
| + | } |
− | <ul>
| + | </script> |
− | <li>Naturally we shared our project and knowledge with the public and talked about the ethical aspects. We had a lot of fun at our different human practice activities.</li>
| + | </body> |
− | </ul>
| + | |
− | | + | |
− | </div>
| + | |
− | | + | |
− | <div id="Gold" class="w3-container requirement" style="padding-top: 10px;">
| + | |
− | <h2>Gold</h2>
| + | |
− | | + | |
− | <h4><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#IHP">Integrated Human Practices</a></h4>
| + | |
− | <ul>
| + | |
− | <liConstructive to our <a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Human Practice</a> work we visited the <a href="https://2016.igem.org/Team:Duesseldorf/Outreach#BfArM">BfArM (the german equivalent of the FDA) and the Paul Ehrlich Institute</a> which is responsible for admission of genetherapeutics to consult professional critics concerning future applications our project </li>
| + | |
− | </ul>
| + | |
− | | + | |
− | <h4>Proof of concept</h4>
| + | |
− | <ul>
| + | |
− | <li>We are really happy that we are able to show a functional proof of concept of our project with one of our newly created BioBricks</li>
| + | |
− | </ul>
| + | |
− | | + | |
− | <h4><a href="https://2016.igem.org/Team:Duesseldorf/Demonstrate">Demonstrate your work</a></h4>
| + | |
− | <ul>
| + | |
− | <li>we were able to show our functional proof of concept under real world conditions with experiments in human cancer cell culture </li>
| + | |
− | </ul>
| + | |
− | | + | |
− | </div>
| + | |
− | </div> | + | |