Line 1: | Line 1: | ||
− | < | + | <html> |
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
<head> | <head> | ||
Line 62: | Line 6: | ||
<link rel="shortcut icon" href="https://static.igem.org/mediawiki/2014hs/2/2f/Tas_igemlogo.png"> | <link rel="shortcut icon" href="https://static.igem.org/mediawiki/2014hs/2/2f/Tas_igemlogo.png"> | ||
<link href='http://fonts.googleapis.com/css?family=Lato' rel='stylesheet' type='text/css'> | <link href='http://fonts.googleapis.com/css?family=Lato' rel='stylesheet' type='text/css'> | ||
− | <link rel="stylesheet" href=" | + | <link rel="stylesheet" href="https://2015.igem.org/Template:TAS_Taipei/css/compiled?action=raw&ctype=text/css"> |
− | <link rel="stylesheet" href=" | + | <link rel="stylesheet" href="https://2015.igem.org/Template:TAS_Taipei/css/bootstrap?action=raw&ctype=text/css"> |
<script>localStorage.clear();</script> | <script>localStorage.clear();</script> | ||
− | <script src="https://2015.igem.org/Template:TAS_Taipei/js/jquery?action=raw& | + | <script src="https://2015.igem.org/Template:TAS_Taipei/js/jquery?action=raw&ctype=text/javascript"></script> |
− | <script src='https://2015.igem.org/Template:TAS_Taipei/js/bootstrap?action=raw& | + | <script src='https://2015.igem.org/Template:TAS_Taipei/js/bootstrap?action=raw&ctype=text/javascript'></script> |
− | <script src="https://2015.igem.org/Template:TAS_Taipei/js/jquerySlides?action=raw& | + | <script src="https://2015.igem.org/Template:TAS_Taipei/js/jquerySlides?action=raw&ctype=text/javascript"></script> |
Line 102: | Line 46: | ||
</div> | </div> | ||
<div> | <div> | ||
− | <h5><a href="https://2015.igem.org/Team:TAS_Taipei/Parts"> | + | <h5><a href="https://2015.igem.org/Team:TAS_Taipei/Parts">Parts</a></h5> |
</div> | </div> | ||
</div> | </div> | ||
<div style='height:140px;'> | <div style='height:140px;'> | ||
<img src="https://static.igem.org/mediawiki/2015/5/5b/Tas_icon_project.png"> | <img src="https://static.igem.org/mediawiki/2015/5/5b/Tas_icon_project.png"> | ||
− | <h4><b> | + | <h4><b>Granzyme B</b> - a blessing and a curse. It's crucial for controlling cancer, but it causes damage when out of cellular space. Let's find the best of both worlds with <b>selective GzmB Inhibition.</b></h4> |
</div> | </div> | ||
Line 233: | Line 177: | ||
<br> | <br> | ||
<br> | <br> | ||
− | <div class="row center-block" style = "padding:10px;width:960px;background-color:# | + | <div class="row center-block" style = "padding:10px;width:960px;background-color:#FFC107;box-shadow:0px 0px 5px black"> |
<div class="row" style = "text-align:center;"> | <div class="row" style = "text-align:center;"> | ||
<div class="col-sm-2"> | <div class="col-sm-2"> | ||
− | <a href="https:// | + | <a href="https://2015.igem.org/Team:TAS_Taipei" style='text-decoration: none'><img src="https://static.igem.org/mediawiki/2015/2/2f/Tas_igemlogo.png |
" alt="" style="width: 100px;"></a> | " alt="" style="width: 100px;"></a> | ||
</div> | </div> | ||
<div class="col-sm-8" style='text-align:center;'> | <div class="col-sm-8" style='text-align:center;'> | ||
− | <a href="https:// | + | <a href="https://2015.igem.org/Team:TAS_Taipei" style='text-decoration: none;'> |
<h2 style="font-family:'Lato';letter-spacing:10px;color: white; font-size: 60px; margin-top: 0; margin-bottom: 0;"><b> | <h2 style="font-family:'Lato';letter-spacing:10px;color: white; font-size: 60px; margin-top: 0; margin-bottom: 0;"><b> | ||
− | + | <img style = "height:64px;vertical-align:top" src = "https://static.igem.org/mediawiki/2015/5/5b/Tas_icon_project.png">RANZYME B</b></h2> | |
</a> | </a> | ||
</div> | </div> | ||
Line 251: | Line 195: | ||
</div> | </div> | ||
− | <script type="text/javascript" src="https://2015.igem.org/Template:TAS_Taipei/js/jssor?action=raw& | + | <script type="text/javascript" src="https://2015.igem.org/Template:TAS_Taipei/js/jssor?action=raw&ctype=text/javascript"></script> |
− | <script type="text/javascript" src="https://2015.igem.org/Template:TAS_Taipei/js/jssorSlider?action=raw& | + | <script type="text/javascript" src="https://2015.igem.org/Template:TAS_Taipei/js/jssorSlider?action=raw&ctype=text/javascript"></script> |
<br> | <br> | ||
Line 271: | Line 215: | ||
var options = { | var options = { | ||
$AutoPlay: true, | $AutoPlay: true, | ||
− | $AutoPlayInterval: | + | $AutoPlayInterval: 10000, |
$SlideDuration: 500, | $SlideDuration: 500, | ||
$DragOrientation: 3, //[Optional] Orientation to drag slide, 0 no drag, 1 horizental, 2 vertical, 3 either, default value is 1 (Note that the $DragOrientation should be the same as $PlayOrientation when $DisplayPieces is greater than 1, or parking position is not 0) | $DragOrientation: 3, //[Optional] Orientation to drag slide, 0 no drag, 1 horizental, 2 vertical, 3 either, default value is 1 (Note that the $DragOrientation should be the same as $PlayOrientation when $DisplayPieces is greater than 1, or parking position is not 0) | ||
Line 313: | Line 257: | ||
<div u="slides" style="cursor: move; position: absolute; left: 0px; top: 0px; width: 1080px; height: 600px; | <div u="slides" style="cursor: move; position: absolute; left: 0px; top: 0px; width: 1080px; height: 600px; | ||
overflow: hidden;"> | overflow: hidden;"> | ||
+ | <div><div u="image" style = "lightgrey;text-align:center"><image style = "width:1080px" src="https://static.igem.org/mediawiki/2015/5/5e/GroupPic.jpeg"/></div> | ||
+ | <div u="caption" t="T" style="box-shadow: 0 0 10px 0;background-color:purple;padding:10px;position: absolute; top: 30px; left: 120px;border-style:solid;border-color:gold;border-width:10px"> | ||
+ | <p style = "color:white;font-size:30px;"> | ||
+ | <b>GRAND PRIZE WINNER | ||
+ | </p> | ||
+ | <p style = "color:white;font-size:30px;"> | ||
+ | BEST WIKI</b> | ||
+ | </p> | ||
+ | <p style = "color:white;font-size: 20px; margin:0"> | ||
+ | Nominated: Best Education and Public Engagement, Poster, Presentation, New Composite Part | ||
+ | </p> | ||
+ | </div> | ||
+ | </div> | ||
<div><img u="image" src="https://static.igem.org/mediawiki/2015/0/00/Tas_frontpage_1.png"/></div> | <div><img u="image" src="https://static.igem.org/mediawiki/2015/0/00/Tas_frontpage_1.png"/></div> | ||
<div><div u="image" style = "lightgrey;text-align:center"><image src="https://static.igem.org/mediawiki/2015/d/df/Bg_fig6.gif"/></div> | <div><div u="image" style = "lightgrey;text-align:center"><image src="https://static.igem.org/mediawiki/2015/d/df/Bg_fig6.gif"/></div> | ||
<div u="caption" t="L" style="box-shadow: 0 0 10px 0;background-color:orange;padding:20px;position: absolute; top: 30px; left: 30px;"> | <div u="caption" t="L" style="box-shadow: 0 0 10px 0;background-color:orange;padding:20px;position: absolute; top: 30px; left: 30px;"> | ||
<p style = "color:white;font-size:32px;"> | <p style = "color:white;font-size:32px;"> | ||
− | + | INHIBITING GRANZYME B | |
</p> | </p> | ||
<p style = "color:white;font-size: 20px"> | <p style = "color:white;font-size: 20px"> | ||
− | Our device produces | + | Our device produces a GzmB inhibitor |
</p> | </p> | ||
</div> | </div> | ||
Line 335: | Line 292: | ||
</div> | </div> | ||
<div><div u="image" style = "text-align:center"><image src="https://static.igem.org/mediawiki/2015/6/6c/Tas_frontpage_2.jpeg"/></div> | <div><div u="image" style = "text-align:center"><image src="https://static.igem.org/mediawiki/2015/6/6c/Tas_frontpage_2.jpeg"/></div> | ||
− | <div u="caption" t="L" style="box-shadow: 0 0 10px 0;background-color:orange;padding:10px;position: absolute; top: | + | <div u="caption" t="L" style="box-shadow: 0 0 10px 0;background-color:orange;padding:10px;position: absolute; top: 330px; left: 20px;"> |
<p style = "width:350px; color:white;font-size:22px;"> | <p style = "width:350px; color:white;font-size:22px;"> | ||
− | "iGEM | + | "I appreciate the interdisciplinary aspect of iGEM. Aside from its strong focus on science which I enjoyed, iGEM also incorporates human, design, and technological elements." |
</p> | </p> | ||
<p style = "color:white;font-size: 16px"> | <p style = "color:white;font-size: 16px"> | ||
− | - | + | - Joseph Chuang |
</p> | </p> | ||
</div> | </div> | ||
Line 388: | Line 345: | ||
<div class = "card" id = "bodycontainer" style = "overflow:hidden;font-family:Lato; text-align:left;"> | <div class = "card" id = "bodycontainer" style = "overflow:hidden;font-family:Lato; text-align:left;"> | ||
<div class = "col-sm-12"> | <div class = "col-sm-12"> | ||
− | <h1 style = "padding:10px;background-color: rgb(33, | + | <h1 style = "padding:10px;background-color: rgb(33,150,243);color:white"> |
ABSTRACT | ABSTRACT | ||
</h1> | </h1> | ||
Line 394: | Line 351: | ||
<div class = "col-sm-1"></div> | <div class = "col-sm-1"></div> | ||
<div class = "col-sm-10"><br> | <div class = "col-sm-10"><br> | ||
− | + | <b>Elevated Granzyme B (GzmB)</b> levels are associated with many chronic inflammatory conditions including vascular, autoimmune and skin diseases. As a serine protease that induces apoptosis in tumor cells, GzmB is an essential part of the immune system. However, high levels of GzmB also result in the <b>random cleavage of extracellular matrix (ECM) proteins</b>, which leads to <b>damaged tissue structure and elasticity</b>. Our project aim is to <b>prevent tissue damage from chronic inflammation</b> by <b>limiting GzmB activity in the ECM</b> without affecting its intracellular functions. We mutated an extracellular protein (ACT) to allow it to bind and inhibit GzmB specifically in the ECM. To deliver this GzmB inhibitor into inflamed sites without bacteria entering the body, we envision two different prototypes: a bandage with a semi-permeable membrane to target localized sites, and a cream containing only the desired protein for general topical use. | |
− | + | ||
</div> | </div> | ||
<br> | <br> | ||
Line 411: | Line 367: | ||
<canvas id="canvas-container" style = "z-index:-1"></canvas> | <canvas id="canvas-container" style = "z-index:-1"></canvas> | ||
− | <script type="text/javascript" src='https://2015.igem.org/Template:TAS_Taipei/js/field?action=raw& | + | <script type="text/javascript" src='https://2015.igem.org/Template:TAS_Taipei/js/field?action=raw&ctype=text/javascript'></script> |
</body> | </body> | ||
− | <!--?action=raw& | + | <!--?action=raw&ctype=text/javascript--> |
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
</html> | </html> |
Revision as of 22:19, 10 July 2016
ABSTRACT
Elevated Granzyme B (GzmB) levels are associated with many chronic inflammatory conditions including vascular, autoimmune and skin diseases. As a serine protease that induces apoptosis in tumor cells, GzmB is an essential part of the immune system. However, high levels of GzmB also result in the random cleavage of extracellular matrix (ECM) proteins, which leads to damaged tissue structure and elasticity. Our project aim is to prevent tissue damage from chronic inflammation by limiting GzmB activity in the ECM without affecting its intracellular functions. We mutated an extracellular protein (ACT) to allow it to bind and inhibit GzmB specifically in the ECM. To deliver this GzmB inhibitor into inflamed sites without bacteria entering the body, we envision two different prototypes: a bandage with a semi-permeable membrane to target localized sites, and a cream containing only the desired protein for general topical use.