Difference between revisions of "Team:TAS Taipei/Modeling"

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<a href="https://2015.igem.org/Team:TAS_Taipei/project"><h4 class="dropdown-toggle disabled" data-toggle="dropdown"><b>PROJECT</b></h4></a>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/project#background">Background</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/project/achievements">Achievements</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Collaborations">Collaborations</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Parts">Parts</a></h5>
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<img src="https://static.igem.org/mediawiki/2015/5/5b/Tas_icon_project.png">
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<h4><b>Granzyme B</b> - a blessing and a curse. It's crucial for controlling cancer, but it causes damage when out of cellular space. Let's find the best of both worlds with <b>selective GzmB Inhibition.</b></h4>
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<a href="https://2015.igem.org/Team:TAS_Taipei/wetlab"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>EXPERIMENTAL</b></h4></a>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/wetlab#construct">Granzyme Inhibitor Construct</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/wetlab#prototype">Prototype Work</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/wetlab#safety">Safety Switch</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Notebook">Notebook</a></h5>
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<img src="https://static.igem.org/mediawiki/2015/f/f8/Tas_icon_wetlab.png">
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<h4>We conduct science - and we are proud to show it. Follow along with our journey of discovery in the lab.</h4>
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<a href="https://2015.igem.org/Team:TAS_Taipei/Modeling"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>MODELING</b></h4></a>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Modeling#serpin">SerpinA3N vs. GZMB</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Modeling#act">ACT3m vs. GZMB</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Modeling#analysis">Analysis</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Modeling#calculator">Calculator</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Modeling#flux">Flux Model</a></h5>
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<img src="https://static.igem.org/mediawiki/2015/3/3e/Tas_icon_modeling.png">
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<h4>The power of <b>Math and Computation</b> provides us with valuable models and information. Find out how.</h4>
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<a href="https://2015.igem.org/Team:TAS_Taipei/Practices"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>HUMAN PRACTICE</b></h4></a>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Practices#research">Research</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Practices#change">Change</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Practices#outreach">Outreach</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Practices#entertainment">Entertainment</a></h5>
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<img src="https://static.igem.org/mediawiki/2015/0/0f/Tas_icon_hp.png">
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<h4>We want to develop <b>socially concious solutions</b> - one that can be provided to all that need aid. Find out how we tackled <b>social aspects</b> of this project.</h4>
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<a href="https://2015.igem.org/Team:TAS_Taipei/Safety"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>BIOSAFETY</b></h4></a>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Safety#researcher_safety">Researcher Safety</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Safety#environmental_safety">Environmental Safety</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Safety#biobrick_safety">Biobrick Safety</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Safety#local_safety">Local Safety</a></h5>
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<img src="https://static.igem.org/mediawiki/2015/9/91/Tas_icon_safety.png">
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<h4><b>Safety first.</b> Especially in a lab. Here's how we maintained and investigated the integrity and security of our work environment.</h4>
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<a href="https://2015.igem.org/Team:TAS_Taipei/team"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>TEAM</b></h4></a>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/team#members">Members</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/team#tas">About</a></h5>
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<h5><a href="https://2015.igem.org/Team:TAS_Taipei/Attributions">Attributions</a></h5>
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<img src="https://static.igem.org/mediawiki/2015/3/34/Tas_icon_team.png">
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<h4>Behind every tough iGem project lies a tough, hard-working yet cheerful group of students. <b>Meet the team!</b></h4>
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<a href="https://2015.igem.org/Team:TAS_Taipei" style='text-decoration: none'><img src="https://static.igem.org/mediawiki/2015/2/2f/Tas_igemlogo.png
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<h2 style="font-family:'Lato';letter-spacing:10px;color: white; font-size: 60px;  margin-top: 0;  margin-bottom: 0;"><b>
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                    <p style = "color:white;font-size:30px;">
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                    <b>GRAND PRIZE WINNER
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                    <p style = "color:white;font-size:30px;">
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                    BEST WIKI</b>
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                    <p style = "color:white;font-size: 20px; margin:0">
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                    Nominated: Best Education and Public Engagement, Poster, Presentation, New Composite Part
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                    <p style = "color:white;font-size:32px;">
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                    INHIBITING GRANZYME B
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                    <p style = "color:white;font-size: 20px">
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                    Our device produces a GzmB inhibitor
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                    <p style = "color:white;font-size:32px;">
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                    PROTOTYPE
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                    We designed and built a bandage with a semi-permeable membrane
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                    "I appreciate the interdisciplinary aspect of iGEM. Aside from its strong focus on science which I enjoyed, iGEM also incorporates human, design, and technological elements."
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                    - Joseph Chuang
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ABSTRACT
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<b>Elevated Granzyme B (GzmB)</b> levels are associated with many chronic inflammatory conditions including vascular, autoimmune and skin diseases. As a serine protease that induces apoptosis in tumor cells, GzmB is an essential part of the immune system. However, high levels of GzmB also result in the <b>random cleavage of extracellular matrix (ECM) proteins</b>, which leads to <b>damaged tissue structure and elasticity</b>. Our project aim is to <b>prevent tissue damage from chronic inflammation</b> by <b>limiting GzmB activity in the ECM</b> without affecting its intracellular functions. We mutated an extracellular protein (ACT) to allow it to bind and inhibit GzmB specifically in the ECM. To deliver this GzmB inhibitor into inflamed sites without bacteria entering the body, we envision two different prototypes: a bandage with a semi-permeable membrane to target localized sites, and a cream containing only the desired protein for general topical use.
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Revision as of 22:31, 10 July 2016

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