Difference between revisions of "Team:NRP-UEA-Norwich"

 
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<h2>Project Description</h2>
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<h3 style="color:#72c9b6">The Team</h3>
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We are a group of undergraduate students from the University of East Anglia, which is renowned for its environmental awareness and climate change research. We are studying subjects that range from Biological Sciences, Biochemistry, Biomedicine, Computing Sciences, Molecular Biology and Natural Sciences. Having been selected for this year’s iGEM team, we are identifying ways to bring synthetic biology techniques to an interdisciplinary research project that is currently ongoing within our university.
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<a href="https://static.igem.org/mediawiki/2016/e/ef/T--NRP-UEA-Norwich--vrvideo.mp4">Download</a> the video instead.
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<h3 style="color:#72c9b6">The Science</h3>
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Increasing fuel poverty and global climate change is driving the global demand for clean energy. Renewable sources of energy, such as sunlight, remain largely untapped due to challenges arising from the intermittent nature of the source. In a coal fire power plant or a nuclear fission reactor it is possible to control energy output in line with fluctuating demands for power. However with renewable sources, such as wind or solar power, electricity is only generated when the wind is blowing or the sun is shining. Thus, a major challenge for renewable energy sources is in converting these types of renewable energy into fuels that can be used to release the harnessed renewable energy as it is needed. The aim of our project is to use the methods of synthetic biology to prepare biological systems that will store solar energy as hydrogen due to the channelling of electrons from photovoltaic cells into bacteria via proteins termed “molecular nanowires”. In this way bacteria can then use this energy to drive the production of hydrogen, and this can be used to sustainably power vehicles or be burned to produce electricity on demand.
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<h3 style="color:#72c9b6">The Research</h3>
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<span>NRP-UEA Norwich</span>
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‘Rock-breathing’ bacteria such as Shewanella oneidensis MR-1, are microbes that couple the generation of proton-motive force across the cytoplasmic membrane to reduction of minerals, located outside of the cell. The MtrC, MtrA and MtrB proteins come together to form the MtrCAB complex that spans the outer membrane in S. oneidensis MR-1. This complex has been shown to contain a network of iron atoms that conduct electrons between the cell and its environment, leading to them being termed “molecular nanowires”. The electrons transferred across the membrane can then be used by hydrogenase proteins that catalyse the reduction of protons (2H+) to dihydrogen (H2). The process is inefficient however and we aim to explore ways of increasing its efficiency, for example through use of alternative hydrogenases or alternate subunits. Additionally we wish to control protein expression at a genetic level in order to optimise the protein ratio for maximum cellular H2 production. Lastly we are also looking into ways of increasing the efficiency of electron recruitment to hydrogenase by experimenting with various modifications to the enzyme. The MtrCAB proteins have been the focus of several previous iGEM projects and one additional aim of our project will be to improve the utility of biobricks that are already housed within the iGEM repository.
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Ultimately, we hope to increase the yield of clean hydrogen produced from S. oneidensis MR-1 in a microbial-photovoltaic fuel cell. The development of efficient mechanisms for storing of energy produced from renewable sources will help counteract intermittency costs and aid their development and economic viability.
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<h2> Welcome to iGEM 2016! </h2>
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<strong><span style="color:#739ede; text-decoration;">The Problem</span></strong><br/> Global climate change and fuel poverty are some of the biggest challenges facing energy production today. Using renewable energy sources to increase global energy production in a sustainable way is vital to solving this issue. However current technologies have many problems with cost, for example those stemming from intermittency. Go to the background page under project for more information. <br />
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<h5>Before you start: </h5>
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<strong><span style="color:#739ede; text-decoration;">The Solution</span></strong><br/>  
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<p> Please read the following pages:</p>
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<span> <img src="https://static.igem.org/mediawiki/2016/0/00/T--NRP-UEA-Norwich--HydrogenaseGoals.jpg" height="300px" align="right"/> To reduce the energy wasted from intermittency problems with renewable energy sources (such as wind and solar) there has been a lot of research focusing on trying to convert this energy into fuels such as hydrogen, for storage and later use. Biowire’s project uses synthetic biology techniques to engineer the bacterium <i>Shewanella oneidensis</i> MR-1. This bacterium has a ‘nanowire’ which can channel electrons into the cell and to hydrogenase enzymes which can then produce hydrogen.</span><br />
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<li>  <a href="https://2016.igem.org/Requirements">Requirements page </a> </li>
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<li> <a href="https://2016.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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<strong><span style="color:#739ede; text-decoration;">The Goals</span></strong><br/> The overall aim of Biowire’s project is to explore the possibility of using <i>S. oneidensis</i> MR-1 as an bio-catalyst in an energy storage system. By trying to increase the hydrogen output of <i>S. oneidensis</i> MR-1 we are hoping to make this hydrogen production system a more attractive and efficient bioenergy solution to the challenges facing energy production. <br /><br />
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<h5> Styling your wiki </h5>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>  
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&action=edit"> Click here to edit this page! </a></p>
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<h2>Learn About</h2>
  
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<h5>Tips</h5>
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<div class="learnSection" style="background-image:url(https://static.igem.org/mediawiki/2016/2/23/T--NRP-UEA-Norwich--LearnShew.jpg); background-size:cover;"><div class="learnText">Virtual Reality</div><a href="https://2016.igem.org/Team:NRP-UEA-Norwich/Practices/VirtualReality" class="learnBoxLink"></a></div>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<div class="learnSection" style="background-image:url(https://static.igem.org/mediawiki/2016/f/f0/T--NRP-UEA-Norwich--LearnGolden.png); background-size:cover;"><div class="learnText">Golden Gate</div><a href="https://2016.igem.org/Team:NRP-UEA-Norwich/GoldenGate" class="learnBoxLink"></a></div>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2016.igem.org/Calendar">iGEM 2016 calendar</a> </li>
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<li>Have lots of fun! </li>
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<div class="learnSection" style="background-image:url(https://static.igem.org/mediawiki/2016/4/46/T--NRP-UEA-Norwich--LearnComic.png); background-size:cover;"><div class="learnText">Comic</div><a href="https://2016.igem.org/Team:NRP-UEA-Norwich/Practices/Comic" class="learnBoxLink"></a></div>
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<h5>Inspiration</h5>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<p> You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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Latest revision as of 22:23, 19 October 2016

NRP-UEA-NORWICH iGEM

BioWire

NRP-UEA Norwich
The Problem
Global climate change and fuel poverty are some of the biggest challenges facing energy production today. Using renewable energy sources to increase global energy production in a sustainable way is vital to solving this issue. However current technologies have many problems with cost, for example those stemming from intermittency. Go to the background page under project for more information.
The Solution
To reduce the energy wasted from intermittency problems with renewable energy sources (such as wind and solar) there has been a lot of research focusing on trying to convert this energy into fuels such as hydrogen, for storage and later use. Biowire’s project uses synthetic biology techniques to engineer the bacterium Shewanella oneidensis MR-1. This bacterium has a ‘nanowire’ which can channel electrons into the cell and to hydrogenase enzymes which can then produce hydrogen.

 The Goals
The overall aim of Biowire’s project is to explore the possibility of using S. oneidensis MR-1 as an bio-catalyst in an energy storage system. By trying to increase the hydrogen output of S. oneidensis MR-1 we are hoping to make this hydrogen production system a more attractive and efficient bioenergy solution to the challenges facing energy production.

Watch a short video about our daily lives

Learn About

Virtual Reality
Golden Gate
Shewanella
Comic

Sponsors