Difference between revisions of "Team:Pasteur Paris"

 
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<h1><center><span class="cursive">A biosilica-based detection device</span><span>for (re)emerging arboviral infectious diseases</span></center></h1>
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<h1><B>MOS(KIT)O</B> <span>A biosilica-based detection device </br>for (re)emerging arboviral infectious diseases</span></h1>
  
  
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<img src="https://static.igem.org/mediawiki/2016/4/46/ARBOVIRUS_PROPA.png" alt="" width="640" height="310" /><figcaption>  The global distribution of arboviruses. </figure><!--
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<img src="https://static.igem.org/mediawiki/2016/8/8a/T--Pasteur_Paris--Arbovirus_map.png" alt="" width="640" height="310" /><figcaption>  The global distribution of arboviruses. </figure><!--
 
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<img src="https://static.igem.org/mediawiki/2016/2/22/INSECTICIDES.png" alt="" width="640" height="310" /><figcaption> The massive use of insecticides causes resistance in mosquitoes.</figcaption>
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<img src="https://static.igem.org/mediawiki/2016/d/dc/T--Pasteur_Paris--INSECTICIDES.jpg" alt="" width="640" height="310" /><figcaption> The massive use of insecticides causes resistance in mosquitoes.</figcaption>
 
</figure><!--
 
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<img src="https://static.igem.org/mediawiki/2016/3/32/Team.png" alt="" width="640" height="310" />
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<img src="https://static.igem.org/mediawiki/2016/f/f0/T--Pasteur_Paris--Team.png" alt="" width="640" height="310" />
 
<figcaption>After many brainstorming sessions and after an exhaustive literature search...</figcaption>
 
<figcaption>After many brainstorming sessions and after an exhaustive literature search...</figcaption>
 
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<img src="https://static.igem.org/mediawiki/2016/5/5f/T--Pasteur_Paris--Our_project.png" alt="" width="640" height="310" />
 
<figcaption>MOS(KIT)O emerged!! </figcaption>
 
<figcaption>MOS(KIT)O emerged!! </figcaption>
 
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<h2><B>Abstract</span></B></h2>
  
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<FONT size "25px"><p><B>Vector-borne (re) emerging diseases</B> are responsible for severe epidemics worldwide. In most cases, vaccines or treatments are not available, and insecticides are the primary source for vector control. Consequently, <B>over-spraying of insecticides</B> impacts the environment and leads to the selection of insecticide-<B>resistant mosquitoes</B>. Therefore, we developed a novel diagnostic device, <B>Mos(kit)o</B>, that includes a fixed or mobile mosquito trap and a <B>biosilica cellulose composite patch</B> from genetically modified <i>E. coli</i> bacteria. The design of the patch creates a <B>multilayered matrix</B> coated with antibodies able to detect a wide panel of vector-borne pathogens and insecticide-resistant proteins from captured mosquitoes. Additionally, the patch will have 2D barcoded readouts, generating an environmental <B>surveillance database</B>. A precise map of vector hot spots will provide a better assessment and response to vector-borne diseases, assisting local health authorities with <B>anticipating</B> and preparing for an epidemic. Our tool will be <B>user-friendly</B>, <B>safe</B>, and <B>applicable</B>.</p></FONT>
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<div class=text3>
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<p>
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</br></br></br></br>
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<B></a>MOS(KIT)O in the press</br>
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<a href="http://www.lemonde.fr/sciences/article/2016/11/14/la-biologie-synthetique-fait-son-casting_5030987_1650684.html">Le monde</a></br>
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<a href="http://www.makery.info/2016/11/08/ligem-recompense-le-kit-moskito-des-etudiants-pour-linstitut-pasteur/">Makery</a></br>
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<a href="http://frenchculture.org/visual-and-performing-arts/news/moskito-wins-four-awards-igem-2016-championship-boston">French embassy in the United States</a></br>
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<a href="https://www.france-science.org/iGEM-la-biologie-de-synthese-dans.html">Office for Science & Technology at the Embassy of France in the United States</a></br>
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<a href="http://www.di2c.u-psud.fr/evenements/evenement/victoire-des-etudiants-du-m1-pidn-promo-2015-2016-a-la-competition-igem-organisee-a-boston">University of Paris Saclay</a></br>
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<a href="http://www.etsl.fr/accueil.html">Laboratory Techniques school</a></br></B>
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<B><a href="http://www.pasteur.fr/igem">iGEM at Institut Pasteur</a></B></br></br></br></br>
  
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<FONT size "25px"><p>Vector-borne (re) emerging diseases are responsible for severe epidemics worldwide. In most cases, vaccines or treatments are not available, and insecticides are the primary source for vector control. Consequently, over spraying of insecticides impacts the environment and leads to the selection of insecticide resistant mosquitoes. Therefore, we developed a novel diagnostic device, Mos(kit)o that includes a fixed or mobile mosquito trap and a biosilica cellulose composite patch from genetically modified E. coli.</br></br></br></br> The design of the patch creates a multilayered matrix coated with antibodies capable of detecting a wide panel of vector-borne pathogens and insecticide resistant proteins from captured mosquitoes. Additionally, the patch will have 2D barcoded readouts, generating an environmental surveillance database. A precise map of vector hot spots will provide a better assessment and response to vector-borne diseases, assisting local health authorities with anticipating and preparing for an epidemic. Our tool will be user-friendly, safe, and applicable.</p></FONT>
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Latest revision as of 16:21, 1 December 2016