Difference between revisions of "Team:DTU-Denmark"

 
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<h2 style="color:black"> Our Team </h2>
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<p>We are DTU BioBuilders, the iGEM team of the Technical University of Denmark. We study biotechnolgy, bioinformatics, mathematical modelling, environmental engineering and biomedical engineering. Our team consists of 13 graduates and 3 undergraduates. In addition, we have 3 highschool students assisting us in the lab. Our team members come from Denmark, Germany, the Netherlands, Greece, China and Poland. This year we tackle substrate utilization in cell factories and this is our wiki:</p>
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<p>We assembled our team in February. We tried to identify a project that meets the following criteria:
 
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<ul>
 
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<li>Identify a local challenge that has a global impact. </li>
 
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<li>To tackle iGEM with a "Cell Factory Engineering"- perspective</li>
 
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<li>Make a novel contribution to the biobrick registry </li>
 
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<h1 class="main-title">ACHIEVEMENTS</h1>
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<h2> The problem: Waste! </h2>
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        <h3 class="achi">We won a gold medal</h3>
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<p>In Denmark today, less than half the waste produced is recycled, which means that more than 3.5 million tons get burned off each year.</p>
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        <h3 class="achi">We got nominated for Best Hardware, Overgrad</h3>
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        <h3 class="achi">We got nominated for Best Poster, Overgrad</h3>
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<p>We have abundant waste streams from the industry such as glycerol from biodiesel production, byproducts from rapeseed production, used cooking oil and ordinary household waste.</p>
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<p>Cell factories are becoming an increasing factor in the industry today, where different microorganisms are utilized to produce various compounds from therapeutics, organic acids, food additives etc. Currently however, the sustainability of these industrial processes is limited by the narrow substrate range of the organisms used. The most common feeds in use are simple carbohydrates such as glucose produced by enzymatic hydrolysis from edible plants such as maize, rice and wheat.</p>
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<h2>Aim of our project </h2>
 
  
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<p>This project aims to develop the chassis for a versatile and efficient cell factory that
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<h1 class="main-title">YEASTILIZATION</h1>
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can transform abundant waste streams into valuable products using <em>Yarrowia lipolytica</em> and
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state of the art genetic editing techniques.</p>
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                  <h2>The <strong>problem</strong></h2>
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                            In the current state of industrial biotechnology, the vast majority of biorefineries rely on edible substrates such as corn, wheat or sugar cane. This has sparked the food vs. fuel debate, leading to the fundamental question whether we should use our edible crops to feed the growing human population, or to provide sustainable chemicals. The limiting factor for current processes is the lack of molecular tools,
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                            which restricts biotechnology to conventional organisms that are optimised for a limited number of substrates.
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                        </strong></p>
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                <h2>The <strong>solution</strong></h2>
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                    The development of new technologies such as CRISPR/Cas9 and Next-generation sequencing has dramatically reduced the effort required to genetically modify non-model organisms, and is effectively breaking down the barrier between model and non-model organisms. In our project we utilise <i>Yarrowia lipolytica</i>, in order to solve the food vs. fuel dilemma while simultaneously making industrial biotechnology an integrated part of waste handling. <p><i>Scroll down to explore our project</i></p>
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                </strong></p>
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<h2> Our project: a molecular toolbox </h2>
 
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<p>The reason why <em>Y. lipolytica</em> has not been implemented in industry yet is the current lack of tools for genetic engineering.</p>
 
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<p> In our project, we develop and test tools for Y. lipolytica. This set will standardized and based on CRISPR/Cas9-mediated genome editing. Y. lipolytica naturally comes with a high potential for biotechnological applications. By using our toolbox, anyone will be able to easily customize the genome to their needs.</p>
 
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<h2> Wiki template information </h2>
 
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
 
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<h2> Editing your wiki </h2>
 
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
 
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<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&action=edit"> Click here to edit this page! </a></p>
 
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<h5>Tips</h5>
 
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
 
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
 
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<li>Be clear about what you are doing and how you plan to do this.</li>
 
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
 
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
 
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
 
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2016.igem.org/Calendar">iGEM 2016 calendar</a> </li>
 
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<li>Have lots of fun! </li>
 
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<h5>Inspiration</h5>
 
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
 
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
 
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
 
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
 
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
 
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
 
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
 
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</ul>
 
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<h5> Uploading pictures and files </h5>
 
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<p> You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
 
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When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
 
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UPLOAD FILES
 
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                    <h2><strong>Project</strong></h2>
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Latest revision as of 00:29, 3 December 2016

New HTML template for the wiki





ACHIEVEMENTS

We won a gold medal

We got nominated for Best Hardware, Overgrad

We got nominated for Best Poster, Overgrad

YEASTILIZATION

The problem

In the current state of industrial biotechnology, the vast majority of biorefineries rely on edible substrates such as corn, wheat or sugar cane. This has sparked the food vs. fuel debate, leading to the fundamental question whether we should use our edible crops to feed the growing human population, or to provide sustainable chemicals. The limiting factor for current processes is the lack of molecular tools, which restricts biotechnology to conventional organisms that are optimised for a limited number of substrates.

The solution

The development of new technologies such as CRISPR/Cas9 and Next-generation sequencing has dramatically reduced the effort required to genetically modify non-model organisms, and is effectively breaking down the barrier between model and non-model organisms. In our project we utilise Yarrowia lipolytica, in order to solve the food vs. fuel dilemma while simultaneously making industrial biotechnology an integrated part of waste handling.

Scroll down to explore our project

EXPLORE

Project

Wetlab

Compute

Team

Outreach



  • FIND US AT:
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  • DTU BIOBUILDERS
  • DENMARK
  • DTU - SØLTOFTS PLADS, BYGN. 221/002
  • 2800 KGS. LYNGBY

  • E-mail:
  • dtu-biobuilders-2016@googlegroups.com
  • MAIN SPONSORS:
Lundbeck fundation DTU blue dot Lundbeck fundation Lundbeck fundation