Difference between revisions of "Team:MIT/Experiments/Promoters"

Line 10: Line 10:
 
<img src="https://static.igem.org/mediawiki/2016/thumb/4/4f/T--MIT--KHB1177menstrual-cycle.jpeg/240px-T--MIT--KHB1177menstrual-cycle.jpeg" alt = 'menstrual cycle diagram' style='width: 250px: height = 250px; float:right;"  margin: 0 1.5%;>
 
<img src="https://static.igem.org/mediawiki/2016/thumb/4/4f/T--MIT--KHB1177menstrual-cycle.jpeg/240px-T--MIT--KHB1177menstrual-cycle.jpeg" alt = 'menstrual cycle diagram' style='width: 250px: height = 250px; float:right;"  margin: 0 1.5%;>
 
<h2 style="text-decoration:underline; font-family: Trebuchet MS;"> Menstrual Cycle</h2>
 
<h2 style="text-decoration:underline; font-family: Trebuchet MS;"> Menstrual Cycle</h2>
−
<p style="font-family: Verdana;" margin-bottom:2.5em; > The monthly menstrual cycle of a womens' uterus consists of the menstrual, proliferative, and secretory phases. In menstruation, the womens' uterine lining sheds as it removes the egg from the body. Then during the proliferative phase, the surplus of estrogen stimulates the re-growth of the edometrium, also know as the uterine lining. And lastly, during the secretory phase, the levels of estrogen drop some while progesterone becomes the dominant hormone allowing the endometrium to be susceptible to pregnancy. Overall, this cycle lasts a total of 28 days and is large classified by the peaks and drops of estrogen and progesterone.  </p>
+
<p style="font-family: Verdana;"> The monthly menstrual cycle of a womens' uterus consists of the menstrual, proliferative, and secretory phases. In menstruation, the womens' uterine lining sheds as it removes the egg from the body. Then during the proliferative phase, the surplus of estrogen stimulates the re-growth of the edometrium, also know as the uterine lining. And lastly, during the secretory phase, the levels of estrogen drop some while progesterone becomes the dominant hormone allowing the endometrium to be susceptible to pregnancy. Overall, this cycle lasts a total of 28 days and is large classified by the peaks and drops of estrogen and progesterone.  </p>
 +
<br></br>
 +
<br></br>
 +
<br></br>
 +
<br></br>
 +
<br></br>
 +
<br></br>
 +
<br></br>
 
<img src= "https://static.igem.org/mediawiki/2016/a/a7/T--MIT--KHB1177hormone-response.jpeg" alt = 'Hormone response diagram' style="width:250px;height:267px; float:left;"  margin: 0 1.5%; class="rotate90">
 
<img src= "https://static.igem.org/mediawiki/2016/a/a7/T--MIT--KHB1177hormone-response.jpeg" alt = 'Hormone response diagram' style="width:250px;height:267px; float:left;"  margin: 0 1.5%; class="rotate90">
 
<h2 style="text-decoration:underline; font-family: Trebuchet MS;"> Estrogen</h2>
 
<h2 style="text-decoration:underline; font-family: Trebuchet MS;"> Estrogen</h2>

Revision as of 02:13, 7 October 2016

Promoter/Receptor Group Background

How does endometriosis respond to hormones?

menstrual cycle diagram













Hormone response diagram

Estrogen

There are endogenous estrogen receptors in two forms: ER-alpha and ER-beta. When a healthy cell senses estrogen, the ER-alpha receptor is activated and triggers downstream responses by binding to different sites, such as an estrogen responsive element. Diseased cells respond in the same fashion as healthy cells.

Progesterone

There are also endoegenous progesterone receptors in two forms: PR-A and PR-B. When a healthy cell senses progesterone, its PR receptors are activated and trigger downstream responses by binding to different sites, such as a progesterone responsive element. However, in a diseased cell, while progesterone is present, it does not co-activate the progesterone receptors, and in turn does not result in any downstream effects.

How does endometriosis respond to hormones?

Set Up

Write about the experimental set up here

Results

Write about the results here