<p><span class="p">The KaiABC system consists of three core proteins
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that comprise the 24-hour circadian clock endogenous to the cyanobacterium
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<i>Synechocococcus elongatus</i>. Oscillations are driven by
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the kinase activity of KaiC and its interactions with KaiA and KaiB
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which catalyze the cyclic auto-phosphorylation and auto-dephosphorylation
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of KaiC, respectively. The establishment of a modular circadian oscillator
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would be a useful tool for synthetic biology. The Kai oscillator can be
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reconstituted in vitro with purified protein, motivating a previous study
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to transplant the Kai system into <i>E.coli</i> (Chen et al, 2014). Our aim
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is to expand this line of research and transplant the Kai system into
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Saccharomyces cerevisiae, demonstrating this system in eukaryotes for the first time.
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<br>
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</span></p>
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</div>
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<a href="https://2016.igem.org/Team:UChicago/Project">More Info →</a>
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</div>
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</div>
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Revision as of 21:01, 9 October 2016
Welcome to UChicago iGEM 2016!
Want to learn more about synthetic biology? Click here.
OUR TEAM
We're a group of diverse weirdos lookin' to engineer some yeast an have a good time.
If you want to get in touch, shoot us an email at genehackers.uchicago@gmail.com!
