Difference between revisions of "Team:BostonU HW/CSS"

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             <h1></br> BU 2016</h1>
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             <h1></br> Fluigi</h1>
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             <h3>iGem Special Track: Hardware</h3>
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             <h3>Boston University iGem Special Track 2016: Hardware</h3>
 
             <br>
 
             <br>
 
             <a href="#about" class="btn btn-lg btn-dark">Find Out More</a>
 
             <a href="#about" class="btn btn-lg btn-dark">Find Out More</a>
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                     <h2>Fluigi is a specify, design, build workflow to aid microfluidic device development.</h2>
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                     <h2>Fluigi is a tool used to specify, design, and build a microfluidic device.</h2>
 
      
 
      
 
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                     <h2>Background in Microfluidics</h2>
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                     <h2>What are Microfluidics?</h2>
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                               <span class="fa-stack fa-4x" >
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                                 <i class="fa fa-circle fa-stack-2x"></i>
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                                 <i class="fa fa-circle fa-stack-2x" ></i>
 
                                 <i class="fa fa-cloud fa-stack-1x text-primary"></i>
 
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Microfluidic devices consist of valves and channels that can manipulate small volumes of liquids laid out in a customizable fashion. Using this, scientists can reduce reagent costs, automate experiments, and attain a high and more precise throughput with predictable fluid flow.  
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Microfluidic devices are modular and consist of valves and channels that can manipulate small volumes of liquids. Using this, scientists can reduce reagent costs, automate experiments, and attain a high and more precise throughput with predictable fluid flow.  
 
</br>
 
</br>
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However, due to the technical agility, high cost and long build time, microfluidics are not very highly used. The current method of photolithography costs $80,000 and an expert to use.  
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However, due to the technical agility, high cost and long build time, microfluidics are not often used. The current method of photolithography costs about $80,000, and also requires an expert.  
 
<br/>
 
<br/>
 
Here's where Fluigi comes into use!
 
Here's where Fluigi comes into use!
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<h2 align="center"> Where can we use microfluidics? </h2>
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<h2 align="center"> Where can we use Microfluidics? </h2>
 
             <br>
 
             <br>
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- Synthetic Biology. Reference:  
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- Synthetic Biology:
 
<a href="http://pubs.rsc.org/en/content/articlepdf/2014/lc/c4lc00509k"> 'Lab on a Chip', 2014</a>
 
<a href="http://pubs.rsc.org/en/content/articlepdf/2014/lc/c4lc00509k"> 'Lab on a Chip', 2014</a>
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<br>
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</br>
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- Experiments to monitor precise control of the number and concentration of input. Reference:
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- Experiments to monitor precise control of the number and concentration of input:
 
<a href="http://stke.sciencemag.org/content/5/213/ra17.full"> 'Diverse Sensitivity Thresholds in Dynamic Signaling Response by Social Amoebae', 2012</a>
 
<a href="http://stke.sciencemag.org/content/5/213/ra17.full"> 'Diverse Sensitivity Thresholds in Dynamic Signaling Response by Social Amoebae', 2012</a>
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<br>
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</br>
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- Single-cell tracking. Reference:
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- Single-cell tracking:
 
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836382"> 'Microfluidics for Synthetic Biology: From Design to Execution'</a>
 
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836382"> 'Microfluidics for Synthetic Biology: From Design to Execution'</a>
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<br>
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</br>
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- Microchemostat: environment control. Reference:
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- Microchemostat for environmental control:
 
<a href="http://science.sciencemag.org/content/309/5731/137.full">'Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat', 2005</a>
 
<a href="http://science.sciencemag.org/content/309/5731/137.full">'Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat', 2005</a>
 
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                                 <h4>
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                                 <h3>
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                                     <strong>Specify</strong>
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                                     Specify
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                                </h4>
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        </br>   </br>
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                                 <p>Specify your microfluidic tool: inputs, outputs. Are there any limitations in terms of port size, channel width? </p>
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                                 <p>Let's start by defining what the inputs and outputs are to your microfluidic chip! Are there any limitations in terms of port size, channel width? </p>
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<p>These will enable Fluigi to best place and route the control and flow layer of the microfluidic chip. The flow layer is the layer through which fluid flows, and the control layer consists of valves that open and close to pull/push fluid through using pressure.</p>
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<p>Fluigi will best place and route the control layer (valves to push/pull fluid through using pressure) and flow layer (through which fluid flows) of the microfluidic chip.</p>
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<p>One part of the specification, which is the mapper (MM) tool, has been done by our iGem Team. Click the button below to learn more about our MM tool. </p>
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<p>iGem Work: The mapper (MM) tool. Click the button below to learn more about our MM tool. </p>
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  <a href="#" class="btn btn-light">Learn More</a>                    
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  <a href="#" class="btn btn-light">Learn More </a>  
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</h3>         
 
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                                 <h4>
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                                     <strong>Design</strong>
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                                     Design
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                                </h4>
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        </br>   </br>
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                                 <p>Use the Fluigi graphical user interface to view and edit your microfluidic chip. </p>
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                                 <p>Check and visualize your device layout using the Fluigi graphical user interface. </p>
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<p> This graphical user interface ties together the design and build components of Fluigi. The interface has been made completely by the iGEM Team</p>
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<p> This graphical user interface also allows you to edit your design and control the fluids in the microfluidic chip. The interface has been made completely by the iGEM Team</p>
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                                 <a href="#" class="btn btn-light">Learn More</a>
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                                 <a href="#" class="btn btn-light">Learn More </a>
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</h3>
 
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                                <h4>
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                                  <h3>
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                                     <strong>Build</strong>
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                                     Build
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                                </h4>
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                                 <p>Ready to make your chip? Import our design files into a 3D Printer and CNC mill to make the chip! You can also make/change the setup using our parameterized designs.</p>
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                                 <p>Ready to make your chip? Import our design files into a 3D Printer and CNC mill to make the chip and the pump setup! You can also make/change the setup using our parameterized designs.</p>
 
<p> The design of the setup is BU iGEM work, whilst the chip manufacturing is the work of our mentors. </P>
 
<p> The design of the setup is BU iGEM work, whilst the chip manufacturing is the work of our mentors. </P>
 
                                 <a href="#" class="btn btn-light">Learn More</a>
 
                                 <a href="#" class="btn btn-light">Learn More</a>
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</h3>
 
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                       <a href="http://twitter.com/iGemHWBU">Twitter</a>
 
                       <a href="http://twitter.com/iGemHWBU">Twitter</a>
 
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                       <a href="mailto:bu.igemhw2016@gmail.com">Email us here</a>
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                       <a href="mailto:bu.igemhw2016@gmail.com">Email us</a>
 
         <br/>
 
         <br/>
 
                       <a href="http://cidarlab.org/Fluigi">About us</a>
 
                       <a href="http://cidarlab.org/Fluigi">About us</a>

Revision as of 22:37, 26 June 2016


Fluigi

Boston University iGem Special Track 2016: Hardware


Find Out More

Fluigi is a tool used to specify, design, and build a microfluidic device.

What are Microfluidics?


Microfluidic devices are modular and consist of valves and channels that can manipulate small volumes of liquids. Using this, scientists can reduce reagent costs, automate experiments, and attain a high and more precise throughput with predictable fluid flow.
However, due to the technical agility, high cost and long build time, microfluidics are not often used. The current method of photolithography costs about $80,000, and also requires an expert.
Here's where Fluigi comes into use!

Where can we use Microfluidics?


- Synthetic Biology: 'Lab on a Chip', 2014
- Experiments to monitor precise control of the number and concentration of input: 'Diverse Sensitivity Thresholds in Dynamic Signaling Response by Social Amoebae', 2012
- Single-cell tracking: 'Microfluidics for Synthetic Biology: From Design to Execution'
- Microchemostat for environmental control: 'Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat', 2005