We conceived a model in order to handle questions concerning the following situation: A bacterial growth is carried out in a bioreactor, continually supplied in substrate. Bacteria can possess 2 type of plasmids:
So during the growth each bacterium can have no plasmids, either one type of plasmids, or both types.
The aim of the model is to assess the evolution of plasmids throughout the culture, to determine which parameters can matter in the loss of those plasmids, and to precise what are the probabilities for a bacteria to loose its plasmids during cell division. As a plasmids can be a disadvantage for growth (energy spent into replicating processes) or a advantage (protection against a toxin) this question is hard to answer. But in this situation, where one type of plasmid can influence on the presence of the other type of plasmid in (and reciprocally) in the same bacteria, the question become too tough to answer and only a mathematical model can resolve such a interrogation!
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In order to help the iGEM team Bordeaux, we read the paper ... and collect some data about their experiments on plasmids transfer using ....
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