Difference between revisions of "Team:Cardiff Wales/Description"

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           <h1>Cas-Find</h1>
 
           <h1>Cas-Find</h1>
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<p>Cas-Find is a point-of-care diagnostic tool using the CRISPR-Cas9 system with the potential to radically change the speed of STI disease diagnosis.</p>
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<p>Lets take one of the most common sexually transmitted infections in the UK affecting on average 200,000 people each year, chlamydia. Currently to test for this infection you take either a urine sample or swab to determine if the chlamydia bacteria (Chlamydia trachomatis) is present. Analysing the samples involves using nucleic acid amplification tests (NAAT) such as PCR or by growing a chlamydia culture. Cultures incur high costs, have varying sensitivity and limitations for widespread screening whilst both methods are laborious and often time consuming. Cas-Find aims to reduce the time to disease detection. Using the CRISPR-Cas9 system specific sequences on the suspect bacteria can be immediately detected, emitting a measureable fluorescence if present.</p>
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<p>This point-of-care nature of our project can significantly advantage those where lab access if limited, expensive and the speed of diagnosis is crucial in making the appropriate clinical decisions.
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    <p><b>Fig 1. Summary of Cas-Find project</b></p>  
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                    <p><b>Fig 1. Summary of Cas-Find project</b></p>  
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<h3>Use of dCas9 and Luciferase</h3>
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    <h3>Proof of Concept Experiment in <i>E.coli</i></h3>
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                    <p><b>Fig 1. Summary of sgRNA design</b></p>
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          <img id=content width=400 src="https://static.igem.org/mediawiki/2016/f/f0/T--Cardiff_Wales--Cas-Find_sgRNA.svg"/>
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<h4>Targetting dCas9 to E.Coli rRNA</h4>
 
<h4>Targetting dCas9 to E.Coli rRNA</h4>
 
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Revision as of 13:05, 16 October 2016

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Cas-Find

Title

Fig 1. Summary of Cas-Find project

Title

Fig 1. Summary of sgRNA design

Targetting dCas9 to E.Coli rRNA

Mentioned program made by Dr Daniel Pass.

Westminster Presentation, by Andrew Brimer & Christian Donohoe

Cardiff_Wales