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<li>We successfully engineered mechano-responsive cells by expressing mechanosensitive ion channels MscS and P3:FAStm:TRPC1 in mammalian cells. | <li>We successfully engineered mechano-responsive cells by expressing mechanosensitive ion channels MscS and P3:FAStm:TRPC1 in mammalian cells. |
Revision as of 10:33, 17 October 2016
Summary of the main results of mechanosensing
Cells interact with other cells and environment in various ways in order to appropriately respond to the microenvironment changes. One important extracellular physical signal are mechanical forces and adaptation upon mechanical stimuli is crucial for regulating the cell volume, signalization, growth, cell to cell interactions and overall survival.
Mechanical forces such as changes in osmolality, fluid flow, gravity or direct pressure result in changes in tension of the phospholipid bilayer and arrangement of
the cellular cytoskeleton. The detailed mechanism of mechanosensing is not known, however most mechanosensitive receptors respond to mechanical stimuli through opening
of the channel pore and allowing calcium ions to enter the cell
This mechanism, serves as a force-sensing system