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Latest revision as of 13:12, 19 October 2016
Summary of the main results on mechanosensing
Cells interact with other cells and the environment in various ways in order to appropriately respond to microenvironment changes. An important extracellular physical signal is represented by mechanical forces and adaptation upon mechanical stimuli is crucial for regulating the cell volume, signalization, growth, cell to cell interactions and overall survival.
Mechanical forces such as changes in osmolality, fluid flow, gravity or direct pressure result in changes in tension of the phospholipid bilayer, arrangement of the cytoskeleton and opening of cation-permeable channels.
This mechanism serves as a force-sensing system