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<h1>Project description</h1> | <h1>Project description</h1> | ||
<B>Our idea</B> <br> | <B>Our idea</B> <br> | ||
− | By basing biorefineries on an organism with a broad substrate range we will be able to utilize industrial waste-streams as substrate for biorefineries, and leave edible feedstocks for the growing human population. <br> | + | By basing biorefineries on an organism with a broad substrate range we will be able to utilize industrial waste-streams as substrate for biorefineries, and leave edible feedstocks for the growing human population. <br><br> |
Introducing Yarrowia Lipolytica | Introducing Yarrowia Lipolytica |
Revision as of 14:20, 2 August 2016
Project description
Our ideaBy basing biorefineries on an organism with a broad substrate range we will be able to utilize industrial waste-streams as substrate for biorefineries, and leave edible feedstocks for the growing human population.
Introducing Yarrowia Lipolytica In contrast to today’s model organisms, Y. lipolytica has been shown to exhibit excellent growth on a long range of substrates, ranging from reduced sugars, organic acids and even lipids. Due to this broad substrate range, Y. lipolytica is ideal for bio-refineries based on non-conventional substrates. What substrates? Studies have shown Y. lipolytica could support biorefineries based on a long range of both crude and complex substrates. Several studies even suggests Y. lipolytica could support utilising substrates such as wastewater from oils mills, the remains from fish and meat production, leftover glycerol from bio-diesel production and the mixed sugars resulting from hydrolysates of lignocellulosic biomass. Why haven’t anyone done this already?! Despite the great potential of Y. lipolytica to support a biorefinery based on waste streams, realising this with a large scale plant has yet to become a reality. This is mainly due to the frugal toolbox associated with Y. lipolytica, which makes this organism a less desirable as cell factory compared to conventional cell factories such as Escherichia coli, Saccharomyces cerevisiae and Aspergillus niger. Yeastillisation Our project, Yeastillisation, aims to develop a genetic and bioinformatic toolbox, thereby paving the way for the use of Y. lipolytica as a novel cell factory for future biorefineries.