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| − | <h2> BioSynthAge: Do not go gentle into that good night </h2>
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| − | <p> We envision a time in which the human population lives a healthier life, for longer. We will use
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| − | synthetic biology to ensure the ageing world population can both maintain their quality of life and
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| − | extend their lifespan - increasing their ‘healthspan’. The health challenges currently posed by
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| − | ageing are many and complex so we propose a suite of synthetic biology solutions to tackle
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| − | these challenges. Our synthetic biology solutions will include, but not be limited to, the following: <p>
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| − | <p> <b> Oxidative stress – the root of the problem </b> </p>
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| − | <p> Oxidative stress underlies many of the health problems of ageing so we will develop a number
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| − | of free radical mopping devices. These devices will include therapeutic bacterial chassis
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| − | triggered by oxidative-stress to deliver free-radical mopping compounds. To lay a
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| − | conceptual foundation for genetic tools that address ageing within human cells, we will also
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| − | use gene-editing tools to map the relationship between telomerase expression and cellular
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| − | robustness to oxidative stress.</p>
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| − | <p> <b> False teeth – a thing of the past </b> </p>
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| − | <p> Increasing tooth loss remains a feature of old age in humans throughout the world. We will
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| − | harness synthetic biology to improve the dental health of the ageing population by designing
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| − | bacteria that do not cause decay but actually prevent it. These biofilm-fillings will provide a
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| − | regenerative internal environment for the tooth whilst fighting off the surface bacteria that cause
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| − | dental plaques. </p>
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| − | <p> <b> Grey love – it does not have to be dangerous </b> </p>
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| − | <p> You may be surprised to know that sexually transmitted diseases are particularly prevalent in
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| − | elderly populations. By embedding living biosensors into lubricant gels we will simplify the
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| − | process of screening potential partners for sexually transmitted infections – as the gel will glow
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| − | in the night on contact with organisms such as Neisseria gonorrhoeae. </p>
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| − | </body>
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| − | <p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
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| − | <h5>What should this page contain?</h5>
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| − | <ul>
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| − | <li> A clear and concise description of your project.</li>
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| − | <li>A detailed explanation of why your team chose to work on this particular project.</li>
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| − | <li>References and sources to document your research.</li>
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| − | <li>Use illustrations and other visual resources to explain your project.</li>
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| − | </ul>
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| − | </div>
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| − | <h5>Advice on writing your Project Description</h5>
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| − | We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.
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| − | </p>
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| − | <p>
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| − | Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.
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| − | </p>
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| − | <h5>References</h5>
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| − | <p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
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| − | </div>
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| − | <h5>Inspiration</h5>
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| − | <p>See how other teams have described and presented their projects: </p>
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| − | <ul>
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| − | <li><a href="https://2014.igem.org/Team:Imperial/Project"> Imperial</a></li>
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| − | <li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> UC Davis</a></li>
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| − | <li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">SYSU Software</a></li>
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| − | </ul>
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| − | </div>
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