|
|
| Line 1: |
Line 1: |
| | {{UCL/jamesy-template}} | | {{UCL/jamesy-template}} |
| | <div class="container-fluid page-heading" style="background-image: url(https://static.igem.org/mediawiki/2016/f/fe/Ucligemaman2.jpg)"> | | <div class="container-fluid page-heading" style="background-image: url(https://static.igem.org/mediawiki/2016/f/fe/Ucligemaman2.jpg)"> |
| − | <h3>Description</h3> | + | </div> |
| − | </div>
| + | |
| − | <div class="container-fluid">
| + | |
| − | <div class="section" id="Biosynthage: Do not go gentle into that good night">
| + | |
| − | <div class="slim">
| + | |
| − | <h2>Biosynthage: Do not go gentle into that good night</h2>
| + | |
| − | <p> We envision a time in which the human population lives a healthier life, for longer. We will use synthetic biology to ensure the ageing world population can both maintain their quality of life and
| + | |
| − | extend their lifespan - increasing their ‘healthspan’. The health challenges currently posed by
| + | |
| − | ageing are many and complex so we propose a suite of synthetic biology solutions to tackle
| + | |
| − | these challenges. Our synthetic biology solutions will include, but not be limited to, the following: </p>
| + | |
| − | </div>
| + | |
| − | </div>
| + | |
| − | | + | |
| − | <div class="section-spacer"></div>
| + | |
| − | <div class="section" id="Oxidative stress – the root of the problem">
| + | |
| − | <div class="slim">
| + | |
| − | <h2>Oxidative stress – the root of the problem</h2>
| + | |
| − | <p> Oxidative stress underlies many of the health problems of ageing so we will develop a number
| + | |
| − | of free radical mopping devices. These devices will include therapeutic bacterial chassis
| + | |
| − | triggered by oxidative-stress to deliver free-radical mopping compounds. To lay a
| + | |
| − | conceptual foundation for genetic tools that address ageing within human cells, we will also
| + | |
| − | use gene-editing tools to map the relationship between telomerase expression and cellular
| + | |
| − | robustness to oxidative stress.</p>
| + | |
| − | | + | |
| − | </div>
| + | |
| − | </div>
| + | |
| − | | + | |
| − | <div class="section-spacer"></div>
| + | |
| − | <div class="section" id="False teeth – a thing of the past">
| + | |
| − | <div class="slim">
| + | |
| − | <h2>False teeth – a thing of the past </h2>
| + | |
| − | <p> Increasing tooth loss remains a feature of old age in humans throughout the world. We will
| + | |
| − | harness synthetic biology to improve the dental health of the ageing population by designing
| + | |
| − | bacteria that do not cause decay but actually prevent it. These biofilm-fillings will provide a
| + | |
| − | regenerative internal environment for the tooth whilst fighting off the surface bacteria that cause
| + | |
| − | dental plaques. </p>
| + | |
| − | </div>
| + | |
| − | </div>
| + | |
| − | | + | |
| − | <div class="section-spacer"></div>
| + | |
| − | <div class="section" id="Grey love – it does not have to be dangerous ">
| + | |
| − | <div class="slim">
| + | |
| − | <h2>Grey love – it does not have to be dangerous </h2>
| + | |
| − | <p> You may be surprised to know that sexually transmitted diseases are particularly prevalent in
| + | |
| − | elderly populations. By embedding living biosensors into lubricant gels we will simplify the
| + | |
| − | process of screening potential partners for sexually transmitted infections – as the gel will glow
| + | |
| − | in the night on contact with organisms such as Neisseria gonorrhoeae. </p>
| + | |
| − | | + | |
| − | </div>
| + | |
| − | </div>
| + | |
| − | | + | |
| − | </div>
| + | |
