Difference between revisions of "Team:Slovenia"

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<h2> Project description </h2>
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<h2> Sonicell </h2>
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<p>In the past years of iGEM and synthetic biology a lot of projects have been devoted to the development of synthetic genetic circuits and logic gates. Most of those were based on transcription regulation, however this mechanism is relatively slow and the final output can be detected only after several hours or days.<br>
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<p>Synthetic biology opens exciting perspectives to design and apply regulatory circuits to control cellular response. Transcriptional regulation may be too slow for therapeutic or diagnostic applications. Several medical doctors and researchers that we consulted stressed the wish for a faster response. Therefore we decided to select as the challenge to design faster responsive cellular circuits. The system we aim to design is composed of the sensing module, which may be triggered by selected molecules, light or other signals; a processing module, which combines different inputs based on protein modifications and interactions and an output module, to provide rapid release of the selected proteins from cells, with a target specification to achieve a response within minutes rather than within hours and days, characteristic for current mammalian cell circuits. We expect that the proof of principle of the designed system and newly designed components may provide important foundational advances for synthetic biology.  
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This year team Slovenia has decided to tackle the problem of the design of fast logic circuits. We plan to introduce new protein-based sensors that will allow cells to quickly respond to input signals such as light stimulation or chemical dimerizers and produce outputs that could potentially be used for therapeutic treatment.
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Revision as of 16:55, 12 September 2016

Sonicell

Synthetic biology opens exciting perspectives to design and apply regulatory circuits to control cellular response. Transcriptional regulation may be too slow for therapeutic or diagnostic applications. Several medical doctors and researchers that we consulted stressed the wish for a faster response. Therefore we decided to select as the challenge to design faster responsive cellular circuits. The system we aim to design is composed of the sensing module, which may be triggered by selected molecules, light or other signals; a processing module, which combines different inputs based on protein modifications and interactions and an output module, to provide rapid release of the selected proteins from cells, with a target specification to achieve a response within minutes rather than within hours and days, characteristic for current mammalian cell circuits. We expect that the proof of principle of the designed system and newly designed components may provide important foundational advances for synthetic biology.

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