Difference between revisions of "Team:Denver Biolabs"

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{{Denver Biolabs}}
 
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<h2> Project Description </h2>
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<p>In 2015, over 300,000 women died during pregnancy and childbirth; 99% of these deaths occurred in developing countries. Postpartum hemorrhage (PPH), or severe bleeding after birth, is the leading cause of maternal mortality worldwide. Oxytocin is a naturally occurring hormone and a medication that is used to increase contractions in the uterus (i.e., induce labor). It has also proved effective in significantly reducing the risk of PPH. Oxytocin is now routinely used in industrialized countries, and is often given in small doses simply as a preventative measure in normal labors. However, oxytocin is not readily available in developing countries. Despite being on the World Health Organization’s List of Essential Medicines for developing countries and being relatively inexpensive (as of 2014, the wholesale cost of the medication is US$0.1–0.56 per dose), oxytocin requires storage at between 2 and 8 °C, which has led to a shortage of this critical drug in rural areas that lack reliable refrigeration, power, and infrastructure. <b>Quality issues with existing oxytocin inventories have also been identified as a significant issue in rural areas.</b></p>
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<p></p>
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<p>Our first goal is to build an oxytocin detection system using a G-protein coupled receptor in yeast that will allow us to verify the presence of active oxytocin. If successful, we will then focus our efforts on synthesizing oxytocin in various forms to increase its availability in resource-poor areas.</p>
 
  
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<p>Oxytocin is produced in the body by the OXT gene. It is synthesized as an inactive precursor peptide along with its carrier molecule neurophysin I. After several iterations of hydrolyzation via enzymes, the active oxytocin molecule is produced. In 2013 an iGEM team from Lethbridge Canada created a form of oxytocin still attached to its carrier molecule, neurophysin I, which prevents degradation until the carrier molecule is cleaved resulting in the activation of the oxytocin molecule. Our team plans to significantly build on this prior work by exploring several other approaches to improving the stability of oxytocin including producing a powdered form of the drug that can be activated using hydrolysis, adding trace metals to prevent oxidation, and using optogenetic techniques to activate oxytocin using light. In addition to these synthetic biology approaches, the diversity of our team’s skills will allow us to explore several mechanical and hardware solutions including simple, non-refrigerated single-injection systems; biological packaging solutions to prevent oxytocin’s degradation; and <b>testing systems to evaluate the quality and effectiveness of current oxytocin inventories.</b> The solutions we plan to explore will target practices ranging from manufacturing, transportation and storage, and distribution to drug administration protocols, drug quality monitoring and control, and improved documentation and inventory to support further research and quality care.The potential impact of any and all of these solutions will be to increase the availability of oxytocin for use in under-resourced maternity facilities.  
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<ul id="accordion" class="accordion">
 +
 
 +
<li class="menu_item"> <a href="https://2016.igem.org/Team:Example">HOME </a> </li>
 +
 
 +
 
 +
<li class="menu_item"> <div class="icon plus"></div> TEAM
 +
<ul class="submenu">
 +
<li> <a href=" https://2016.igem.org/Team:Example/Team"> Team  </a> </li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Collaborations">★  Collaborations </a> </li>
 +
                    </ul>
 +
                </li>
 +
 
 +
<li class="menu_item"> <div class="icon plus"></div> PROJECT 
 +
<ul class="submenu">
 +
<li> <a href="https://2016.igem.org/Team:Example/Description"> ★  Description </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Design"> ★ Design </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Experiments"> Experiments </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Proof"> ★ Proof of Concept </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Demonstrate"> ★ Demonstrate </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Results"> Results </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Notebook"> Notebook </a></li>
 +
                    </ul>
 +
                </li>
 +
 
 +
<li class="menu_item"> <div class="icon plus"></div> PARTS 
 +
<ul class="submenu">
 +
<li> <a href="https://2016.igem.org/Team:Example/Parts">Parts </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Basic_Part"> ★ Basic Parts </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Composite_Part"> ★ Composite Parts </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Part_Collection"> ★ Part Collection </a></li>
 +
                    </ul>
 +
                </li>
 +
 
 +
 
 +
<li class="menu_item"> <a href="https://2016.igem.org/Team:Example/Safety"> SAFETY </a> </li>
 +
 
 +
 
 +
<li class="menu_item"> <a href="https://2016.igem.org/Team:Example/Attributions">★  ATTRIBUTIONS </a></li>
 +
 
 +
 
 +
<li class="menu_item"> <div class="icon plus"></div> HUMAN PRACTICES
 +
<ul class="submenu">
 +
<li> <a href="https://2016.igem.org/Team:Example/Human_Practices"> Human Practices </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/HP/Silver">★ Silver </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/HP/Gold">★ Gold </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Integrated_Practices"> ★ Integrated Practices </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Engagement">★ Engagement </a></li>
 +
                    </ul>
 +
                </li>
 +
 
 +
 
 +
<li class="menu_item"> <div class="icon plus"></div> AWARDS
 +
<ul class="submenu">
 +
<li><a href="https://2016.igem.org/Team:Example/Entrepreneurship"> ★ Entrepreneurship </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Hardware"> ★ Hardware </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Software">★ Software </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Measurement">★  Measurement </a></li>
 +
<li> <a href="https://2016.igem.org/Team:Example/Model">★ Model </a></li>
 +
 
 +
                    </ul>
 +
                </li>
 +
</ul>
 +
 
 +
</div>
 +
 
 +
 
 +
 
 +
 
 +
 
 +
<div class="content_wrapper">
 +
 
 +
 
 +
 
 +
<h1 id="team_name">  </h1>
 +
<h4 id="page_name">  </h4>
 +
 
 +
 
 +
 
 +
 
 +
 
 +
 
 +
 
 +
 
 +
 
 +
<script>
 +
 
 +
// This is the jquery part of your template.  Try not modify any of this code since it makes your menu work.
 +
 
 +
$(document).ready(function() {
 +
 
 +
$("#HQ_page").attr('id','');
 +
 +
 
 +
if ( wgPageName.substring( 0,  8) == "Template")  {  // if the page is a template it displays the full name in a single line
 +
$("#team_name").html( wgPageName );
 +
}
 +
 
 +
else if (  ( (wgPageName.match(/\//g) || []).length ) == 0 ) {  // if it is the home page , just print the team's name
 +
$("#team_name").html( wgPageName.substring( 5, wgPageName.length ) );
 +
}
 +
 
 +
else {
 +
// this adds the team's name as an h1
 +
$("#team_name").html( wgPageName.substring( 5 , wgPageName.indexOf("/")  ) );
 +
 
 +
// this adds the page's title as an h4
 +
$("#page_name").html (    ( wgPageName.substring( wgPageName.indexOf("/") + 1, wgPageName.length ) ).replace( /\/|_/g , " ")  );
 +
}
 +
 
 +
 
 +
 
 +
 
 +
$('#accordion').find('.menu_item').click(function(){
 +
 
 +
//Expand or collapse this panel
 +
submenu = $(this).find('.submenu');
 +
submenu.toggle();
 +
 
 +
icon = $(this).find('.icon');
 +
 
 +
if ( !$( submenu ).is(':visible') ) {
 +
icon.removeClass("less").addClass("plus");
 +
}
 +
else {
 +
icon.removeClass("plus").addClass("less");
 +
}
 +
 
 +
//Hide the other panels
 +
$(".submenu").not(submenu).hide();
 +
$(".icon").not(icon).removeClass("less").addClass("plus");
 +
});
 +
 
 +
 
 +
$(".collapsable_menu_control").click(function() {
 +
$(".menu_item").toggle();
 +
});
 +
 
 +
$( window ).resize(function() {
 +
$(".menu_item").show();
 +
});
 +
 
 +
 
 +
});
 +
 
 +
 
 +
 
 +
 
 +
</script>
 +
 
 +
 
 +
 
 +
 
 +
 
 +
<div class="column full_size" >
 +
<img src="http://placehold.it/800x300/d3d3d3/f2f2f2">
 +
</div>
 +
 
 +
<div class="column full_size" >
 +
<h2> Welcome to iGEM 2016! </h2>
 +
<p>Your team has been approved and you are ready to start the iGEM season! </p>
  
 
</div>  
 
</div>  
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<li>  <a href="https://2016.igem.org/Requirements">Requirements page </a> </li>
 
<li>  <a href="https://2016.igem.org/Requirements">Requirements page </a> </li>
 
<li> <a href="https://2016.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
 
<li> <a href="https://2016.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
−
<li> <a href="https://2016.igem.org/Resources/Template_Documentation"> Template Documentation </a></li>
 
 
</ul>
 
</ul>
 
</div>
 
</div>
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<h5> Editing your wiki </h5>
 
<h5> Editing your wiki </h5>
 
<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>  
 
<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>  
−
<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
+
<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&amp;action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
  
 
</div>
 
</div>
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</div>             <div class="visualClear"></div>
 +
            </div>
 +
    </div>
 +
 +
        </div>
 +
 +
        <!-- Side Menubar -->
 +
        <div id="sideMenu">
 +
            <a href="https://2016.igem.org">
 +
                <div id="home_logo" >
 +
                <img src="https://static.igem.org/mediawiki/2016/b/bf/HQ_menu_logo.jpg">
 +
                </div>
 +
            </a>
 +
 +
            <div style="clear:both; height:5px;"></div>
 +
 +
            <div id="menuDisplay"></div>  <!- Menu will be loaded here ->
 +
        </div>
 +
 +
        <!-- Pop_Why Div is definded here -->
 +
        <div class="pop_why_cover"></div>
 +
 +
        <div class="pop_why_box" >
 +
            <div class="pop_close">× </div>
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            <div class="pop_why_content"><h3> Loading ... </h3></div>
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    </div>
 
</html>
 
</html>

Revision as of 23:44, 17 September 2016

<!DOCTYPE html> Team:Example - 2016.igem.org

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Team:Example

MENU ▤

Welcome to iGEM 2016!

Your team has been approved and you are ready to start the iGEM season!

Before you start:

Please read the following pages:

Styling your wiki

You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.

While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.

Wiki template information

We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!

Editing your wiki

On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!

Use WikiTools - Edit in the black menu bar to edit this page

Tips

This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:

  • State your accomplishments! Tell people what you have achieved from the start.
  • Be clear about what you are doing and how you plan to do this.
  • You have a global audience! Consider the different backgrounds that your users come from.
  • Make sure information is easy to find; nothing should be more than 3 clicks away.
  • Avoid using very small fonts and low contrast colors; information should be easy to read.
  • Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2016 calendar
  • Have lots of fun!
Inspiration

You can also view other team wikis for inspiration! Here are some examples:

Uploading pictures and files

You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to
T--YourOfficialTeamName--NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)

UPLOAD FILES

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