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− | <div class=" | + | <!--Slides--> |
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+ | <img src="https://static.igem.org/mediawiki/2016/5/52/T--Duke--Scientist1_and_.jpeg" alt="..."> | ||
+ | <div class="carousel-caption"> | ||
+ | <h2>AFFORDABLE, SAFER CANCER MEDS</h2> | ||
+ | <p>WE INCREASE TAXOL SAFETY AND PRODUCTION DRAMATICALLY <br /> BY USING CONTROLLED BACTERIAL PRODUCERS</p> | ||
+ | </div> | ||
+ | </div> | ||
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+ | <img src="https://static.igem.org/mediawiki/2016/1/1a/T--Duke--Scientist2_and_.jpeg" alt="..."> | ||
+ | <div class="carousel-caption"> | ||
+ | <h2>PREVENT TAXOL SOURCE PLANT EXTINCTION</h2> | ||
+ | <p>TAXOL PLANT IS OVERHARVESTED <br /> DUKE IGEM's ENGINEERED BACTERIA WILL TAKE OVER ALL PRODUCTIOn</p> | ||
+ | </div> | ||
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+ | <img src="https://static.igem.org/mediawiki/2016/f/fe/T--Duke--Scientist3_and_.jpeg" alt="..."> | ||
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+ | <h2>HERE IS BREAKING BAD HAPPENING</h2> | ||
+ | <p> IT'S A REALLY GOOD SHOW!<br/></p> | ||
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+ | </div> | ||
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− | </ | + | <section class="bg-primary" id="about" style="background-image: url(https://static.igem.org/mediawiki/2016/c/c3/T--Duke--Canada_and_.jpeg); background-size: cover; background-position: center"> |
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+ | <div class="text-center" style="padding-left: 5em; height: 20em; padding-top: 8em; color:black"> | ||
+ | <h1 class="section-heading"> <u>How to Produce Lots of <br/>Cancer Drugs Sustainably?</u></h1> | ||
+ | </div> | ||
− | < | + | <p class="text-right" style="color: black;font-family: Indie Flower; Comic Sans MS; font-size: 30px;">Presented by Duke iGEM <img src="https://static.igem.org/mediawiki/2016/c/c4/T--Duke--logo_and_.jpeg" width="10%"></p> |
− | <img src="https://static.igem.org/mediawiki/2016/ | + | </div> |
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− | </ | + | </section> |
− | < | + | <div class="wrapper"> |
− | < | + | <div class="container 75%"> |
− | + | <div class="row"> | |
− | + | <div class="col-md-6"> | |
− | </p> | + | <header class="major"> |
+ | <h2 style="color:#337ab7; font-family: Muli"><span class="glyphicon glyphicon-question-sign" aria-hidden="true"></span> Identifying Cancer Drug in Short Supply</h2> | ||
+ | <p>Our case is taxol, a famous chemotherapy drug that derives its chemistry from Pacific Yew Tree barks.</p> | ||
+ | </header> | ||
+ | <object data="https://sketchfab.com/models/8369d9d8ca004aa3b994cb0e2f392471/embed" width="500px" height="300px"> | ||
+ | <embed src="https://sketchfab.com/models/8369d9d8ca004aa3b994cb0e2f392471/embed"> </embed> | ||
+ | Error: Embedded data could not be displayed. | ||
+ | </object> | ||
+ | <h4 style="font-family:Raleway; display:block; margin-right:1em;text-align:center">Annotated Taxol 2D Structure <span class="text-muted">(3D Structure in Project Page)</span></h4> | ||
+ | <h6>PDB Citation: Bank, RCSB Protein Data. "TAXOL." RCSB PDB. N.p., n.d. Web. 27 Sept. 2016.</h6> | ||
+ | </div> | ||
+ | <div class="col-md-6"> | ||
+ | <p style="font-family: Raleway; font-size:20px">The lack of chemotherapy drugs risks patients' lives. Taxol is a famous and effective cancer drug whose production rests on the steady supply of Pacific Yew Trees. However, as more people develop cancer, Pacific Yew Trees are being overharvested and endangered.</p> | ||
+ | <p style="font-family: Raleway; font-size:20px">In the forseeable future, there will be fewer Yew Trees. Taxol will become less affordable for patients. Worse, when Yew Trees become extinct, Taxol will lose its most essential ingredient. What can we do?</p> | ||
− | < | + | <img src="https://static.igem.org/mediawiki/2016/b/b1/T--Duke--taxolplant_and_.jpeg" class="center" width="50%"> |
− | < | + | </div> |
− | + | ||
− | </ | + | </div> |
+ | </div> | ||
− | < | + | <div class="container-fluid" style="padding-top: 2em"> |
− | < | + | <div class="row"style="background-color:#f6f6f6; padding-top:2em; padding-bottom: 2em;" > |
− | + | <div class="col-md-6" style="padding-left:3.5em"> | |
− | </p> | + | <p style="font-family: Raleway; font-size:20px">After an analysis of Yew Trees' genetic structure relevant to taxol production, we identified eight genetic processes. And these genes are transferrable!</p> |
− | < | + | <p style="font-family: Raleway; font-size:20px">Therefore, it's possible to teach someone else to produce Yew Trees' stuff. The next important step is to find the perfect replacement producer to relieve Yew Trees of their noble duty.</p> |
− | </p> | + | <img src="https://static.igem.org/mediawiki/2016/4/47/T--Duke--concentratingscientist_and_.jpeg" class="center" width="50%"> |
+ | </div> | ||
+ | <div class="col-md-6"> | ||
+ | <header class="major"> | ||
+ | <h2 style="color:#337ab7;font-family: Muli" ><span class="glyphicon glyphicon-search" aria-hidden="true"></span> Rethink the Production Process</h2> | ||
+ | <p>Why don't we get a new producer for this essential taxol ingredient? Our solution will dramatically increase taxol production, create Pacific Yew Trees a permanent break from overharvest and danger of extinction. </p> | ||
+ | </header> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
− | </div> | + | <div class="container 75%" style="padding-top: 2em"> |
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+ | |||
+ | <header class="major"> | ||
+ | <h2 style="color:#337ab7;font-family: Muli"><span class="glyphicon glyphicon-sunglasses" aria-hidden="true"></span> Bacteria!</h2> | ||
+ | <p>Bacterial Production in a controlled lab is safer and sustainable, with a dramatically larger yield!</p> | ||
+ | </header> | ||
+ | </div> | ||
+ | <div class="col-md-6"> | ||
+ | <p style="font-family: Raleway; font-size:20px">At Duke iGEM, we have already begun the process of sequentially arranging these genes and growing bacteria with their new powers. </p> | ||
+ | <p style="font-family: Raleway; font-size:20px">Therefore, it's possible to teach someone else to produce Yew Trees' stuff. The next important step is to find the perfect replacement producer to relieve Yew Trees of their noble duty.</p> | ||
+ | </div> | ||
+ | <img src="https://static.igem.org/mediawiki/2016/b/bf/T--Duke--bacteria_and_.jpeg" class="center" width="40%"> | ||
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Revision as of 02:26, 29 September 2016
How to Produce Lots of
Cancer Drugs Sustainably?
Presented by Duke iGEM
Identifying Cancer Drug in Short Supply
Our case is taxol, a famous chemotherapy drug that derives its chemistry from Pacific Yew Tree barks.
Annotated Taxol 2D Structure (3D Structure in Project Page)
PDB Citation: Bank, RCSB Protein Data. "TAXOL." RCSB PDB. N.p., n.d. Web. 27 Sept. 2016.
The lack of chemotherapy drugs risks patients' lives. Taxol is a famous and effective cancer drug whose production rests on the steady supply of Pacific Yew Trees. However, as more people develop cancer, Pacific Yew Trees are being overharvested and endangered.
In the forseeable future, there will be fewer Yew Trees. Taxol will become less affordable for patients. Worse, when Yew Trees become extinct, Taxol will lose its most essential ingredient. What can we do?
![](https://static.igem.org/mediawiki/2016/b/b1/T--Duke--taxolplant_and_.jpeg)
After an analysis of Yew Trees' genetic structure relevant to taxol production, we identified eight genetic processes. And these genes are transferrable!
Therefore, it's possible to teach someone else to produce Yew Trees' stuff. The next important step is to find the perfect replacement producer to relieve Yew Trees of their noble duty.
![](https://static.igem.org/mediawiki/2016/4/47/T--Duke--concentratingscientist_and_.jpeg)
Rethink the Production Process
Why don't we get a new producer for this essential taxol ingredient? Our solution will dramatically increase taxol production, create Pacific Yew Trees a permanent break from overharvest and danger of extinction.
Bacteria!
Bacterial Production in a controlled lab is safer and sustainable, with a dramatically larger yield!
At Duke iGEM, we have already begun the process of sequentially arranging these genes and growing bacteria with their new powers.
Therefore, it's possible to teach someone else to produce Yew Trees' stuff. The next important step is to find the perfect replacement producer to relieve Yew Trees of their noble duty.
![](https://static.igem.org/mediawiki/2016/b/bf/T--Duke--bacteria_and_.jpeg)