Difference between revisions of "Team:UCL/Lungs"
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<h4> As you get older, you lose the ability of your major organs working at their maximum function. One of these important organs being the lungs. The effects of aging on the respiratory system are similar to those that occur in other systems: there is a decrease in peak airflow and gas exchange and a decline in the effectiveness of lung defence mechanisms. These changes contribute somewhat to an older person's reduced ability to do vigorous exercise, especially intense aerobic exercise. More importantly, these age-related changes in the lungs lead to the development of age related diseases and eventually death. </h4> | <h4> As you get older, you lose the ability of your major organs working at their maximum function. One of these important organs being the lungs. The effects of aging on the respiratory system are similar to those that occur in other systems: there is a decrease in peak airflow and gas exchange and a decline in the effectiveness of lung defence mechanisms. These changes contribute somewhat to an older person's reduced ability to do vigorous exercise, especially intense aerobic exercise. More importantly, these age-related changes in the lungs lead to the development of age related diseases and eventually death. </h4> | ||
<h4> One of these age related diseases being chronic obstructive pulmonary disease (COPD) that and leads to chronic inflammation and progressive destruction of lung tissues. Its currently a major public health problem worldwide and is the 4th leading cause of death in the world. </h4> | <h4> One of these age related diseases being chronic obstructive pulmonary disease (COPD) that and leads to chronic inflammation and progressive destruction of lung tissues. Its currently a major public health problem worldwide and is the 4th leading cause of death in the world. </h4> | ||
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| + | <h3> <center> <b> <u> What actually causes your lung cells to age? </b> </u> </center> </h3> | ||
| + | <h4> Increasing evidence is showing that we accumulate toxins as we age and this is one of the contributing factors that lead to the ageing of our cells. One toxin being free radicals. As our cells burn food, they also generate toxins known as free radicals, that damage every part of our cells, literally bombarding them millions of times per second, damaging all cells. The result: oxidative stress. Because of their anatomy, location and function, the lungs are highly susceptible to oxidative damage. Increasing evidence suggests that oxidative damage of lung cells due to ageing leads to the onset of these age related disease like COPD. </h4> | ||
| + | <h4> Reactive oxygen species (ROS) are free radicals that are generated during oxidative phosphorylation. They have various physiological roles and are removed rapidly from the body [1]. Many papers have suggested that the overproduction of ROS causes DNA damage, cell dysfunction, cell death which lead to the ageing of a cell. Overproduction of ROS is also associated with pathogenesis of some age related diseases including cardiovascular diseases, neurological disorders, and pulmonary diseases [2] . An imbalance between generation of ROS and antioxidant defences leads to oxidative stress in which cell antioxidants are at an insufficient level to keep ROS below a toxic threshold [1]. </h4> | ||
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Revision as of 12:12, 5 October 2016
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Lungs: Superoxide Dismutase Gene therapy
Over expression of antioxidants that break down toxic reactive oxidative species into less harmful hydrogen peroxide. Read more about our novel synthetic biology approach to the prevention of age-related diseases to the lungs.
Ageing of lungs: the problem
As you get older, you lose the ability of your major organs working at their maximum function. One of these important organs being the lungs. The effects of aging on the respiratory system are similar to those that occur in other systems: there is a decrease in peak airflow and gas exchange and a decline in the effectiveness of lung defence mechanisms. These changes contribute somewhat to an older person's reduced ability to do vigorous exercise, especially intense aerobic exercise. More importantly, these age-related changes in the lungs lead to the development of age related diseases and eventually death.
One of these age related diseases being chronic obstructive pulmonary disease (COPD) that and leads to chronic inflammation and progressive destruction of lung tissues. Its currently a major public health problem worldwide and is the 4th leading cause of death in the world.
What actually causes your lung cells to age?
Increasing evidence is showing that we accumulate toxins as we age and this is one of the contributing factors that lead to the ageing of our cells. One toxin being free radicals. As our cells burn food, they also generate toxins known as free radicals, that damage every part of our cells, literally bombarding them millions of times per second, damaging all cells. The result: oxidative stress. Because of their anatomy, location and function, the lungs are highly susceptible to oxidative damage. Increasing evidence suggests that oxidative damage of lung cells due to ageing leads to the onset of these age related disease like COPD.
Reactive oxygen species (ROS) are free radicals that are generated during oxidative phosphorylation. They have various physiological roles and are removed rapidly from the body [1]. Many papers have suggested that the overproduction of ROS causes DNA damage, cell dysfunction, cell death which lead to the ageing of a cell. Overproduction of ROS is also associated with pathogenesis of some age related diseases including cardiovascular diseases, neurological disorders, and pulmonary diseases [2] . An imbalance between generation of ROS and antioxidant defences leads to oxidative stress in which cell antioxidants are at an insufficient level to keep ROS below a toxic threshold [1].
