Difference between revisions of "Team:MIT/Experiments/Promoters"
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<h1 style="background-color:#7ECEFD; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> How does endometriosis respond to hormones?</h1> | <h1 style="background-color:#7ECEFD; -moz-border-radius: 15px; -webkit-border-radius: 15px; padding:15px; text-align: center; font-family: Trebuchet MS"> How does endometriosis respond to hormones?</h1> | ||
| − | <img src= "https://static.igem.org/mediawiki/2016/a/a7/T--MIT--KHB1177hormone-response.jpeg" alt = 'Hormone response diagram' style="width:250px;height:267px; float:left;" class="rotate90"> | + | <img src="https://static.igem.org/mediawiki/2016/thumb/4/4f/T--MIT--KHB1177menstrual-cycle.jpeg/240px-T--MIT--KHB1177menstrual-cycle.jpeg" alt = 'menstrual cycle diagram' style='width: 250px: height = 250px; float:right;" margin: 0 1.5%;> |
| + | <h2 style="text-decoration:underline; font-family: Trebuchet MS;"> Menstrual Cycle</h2> | ||
| + | <p style="font-family: Verdana;" margin-bottom:2.5em; > The monthly menstrual cycle of a womens' uterus consists of the menstrual, proliferative, and secretory phases. In menstruation, the womens' uterine lining sheds as it removes the egg from the body. Then during the proliferative phase, the surplus of estrogen stimulates the re-growth of the edometrium, also know as the uterine lining. And lastly, during the secretory phase, the levels of estrogen drop some while progesterone becomes the dominant hormone allowing the endometrium to be susceptible to pregnancy. Overall, this cycle lasts a total of 28 days and is large classified by the peaks and drops of estrogen and progesterone. </p> | ||
| + | <img src= "https://static.igem.org/mediawiki/2016/a/a7/T--MIT--KHB1177hormone-response.jpeg" alt = 'Hormone response diagram' style="width:250px;height:267px; float:left;" margin: 0 1.5%; class="rotate90"> | ||
<h2 style="text-decoration:underline; font-family: Trebuchet MS;"> Estrogen</h2> | <h2 style="text-decoration:underline; font-family: Trebuchet MS;"> Estrogen</h2> | ||
<p style="font-family: Verdana;">There are endogenous estrogen receptors in two forms: ER-alpha and ER-beta. When a healthy cell senses estrogen, the ER-alpha receptor is activated and triggers downstream responses by binding to different sites, such as an estrogen responsive element. Diseased cells respond in the same fashion as healthy cells. </p> | <p style="font-family: Verdana;">There are endogenous estrogen receptors in two forms: ER-alpha and ER-beta. When a healthy cell senses estrogen, the ER-alpha receptor is activated and triggers downstream responses by binding to different sites, such as an estrogen responsive element. Diseased cells respond in the same fashion as healthy cells. </p> | ||
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<h2 style="text-decoration:underline; font-family: Trebuchet MS;"> Progesterone</h2> | <h2 style="text-decoration:underline; font-family: Trebuchet MS;"> Progesterone</h2> | ||
<p style="font-family:Verdana;"> There are also endoegenous progesterone receptors in two forms: PR-A and PR-B. When a healthy cell senses progesterone, its PR receptors are activated and trigger downstream responses by binding to different sites, such as a progesterone responsive element. However, in a diseased cell, while progesterone is present, it does not co-activate the progesterone receptors, and in turn does not result in any downstream effects. | <p style="font-family:Verdana;"> There are also endoegenous progesterone receptors in two forms: PR-A and PR-B. When a healthy cell senses progesterone, its PR receptors are activated and trigger downstream responses by binding to different sites, such as a progesterone responsive element. However, in a diseased cell, while progesterone is present, it does not co-activate the progesterone receptors, and in turn does not result in any downstream effects. | ||
Revision as of 02:11, 7 October 2016
How does endometriosis respond to hormones?
Estrogen
There are endogenous estrogen receptors in two forms: ER-alpha and ER-beta. When a healthy cell senses estrogen, the ER-alpha receptor is activated and triggers downstream responses by binding to different sites, such as an estrogen responsive element. Diseased cells respond in the same fashion as healthy cells.
Progesterone
There are also endoegenous progesterone receptors in two forms: PR-A and PR-B. When a healthy cell senses progesterone, its PR receptors are activated and trigger downstream responses by binding to different sites, such as a progesterone responsive element. However, in a diseased cell, while progesterone is present, it does not co-activate the progesterone receptors, and in turn does not result in any downstream effects.
How does endometriosis respond to hormones?
Set Up
Write about the experimental set up here
Results
Write about the results here
