Difference between revisions of "Team:UCAS"

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<h5>Degrading Antibiotic Residues in City Water Bodies </h5>
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<h2> Welcome to iGEM 2016! </h2>
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<p>During the course of brainstorm, our team members came up with several ideas including treating diabetes using gut microbes, degrading PCBs in the environment and degrading antibiotic residues.After consulting professionals, we decided to work on degrading antibiotics for several reasons: </p>
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<p>(1) Antibiotic resistant crisis has become a major threat to human health and it has attracted much attention worldwide in recent years. Since antibiotic contaminant is more eminent than others like PCBs, we decided to tackle this problem; </p>
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<p>(2) China is by far the largest antibiotic producing and consuming country in the world, but it was not until recently that the public has been aware of the consequence of antibiotic abuse;</p>
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<p>(3) Researches show that connection of antibiotic residues in city river is relatively high, so this is the practical use of our project; </p>
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<p>(4) Thanks to the works finished by previous teams, we can utilize and enhance some of the submitted parts; </p>
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<p>(5) While most of the previous teams focused on testing the antibiotics in natural environment or some products, we will focus on degrading the antibiotics. Evaluating the degrading efficacy of enzymes is a primary goal of our work;</p>
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<p>Antibiotics have long been extensively used in agriculture, livestock husbandry and medical treatment, but the harm caused by the abuse of antibiotics has not been realized by human society until recently. Researches show that antibiotic residues in water seriously affect human health and ecological safety. China, as a country which uses excessive antibiotics, would suffer from the harm of drug residues more severely. In order to effectively degrade the antibiotic residues in water, the UCAS iGEM team 2016 hope to construct a kind of microorganism which is able to decompose antibiotics with high efficiency. We choose several oxidative methods to solve this problem, and screen several productive oxidases.</p>
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<p>There are mainly three parts to our project.</p>
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<p>(1)The selection of degrading enzymes: Before enzymatic reaction, we first used some active small molecules to test the degradation efficiency of antibiotics. However, the results are not promising, indicating that chemical compounds alone are not sufficient to degrade antibiotics. Next, we will try to practice enzymatic reactions to decompose antibiotics in vitro, and will compare the efficiencies with those of natural resistant genes, so that we would select one or a few oxidases. The enzymes we will screen includes a form of manganese peroxidase(MnCcp) and myoglobin mutants. We choose E. coli as the chassis organism, and evaluate the degrading efficiency in vivo.</p>
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<p>(2)Genetically modified microbes(GMMs) threaten the environment once the artificial genes are transformed to other organisms or released. So we designed a kill-switch to prevent the horizontal-gene-transfer based on Type II TA modules commonly found in prokaryotes. In this summer, we will measure the toxicity of different types of TA modules, in order to screen out the most toxic ones. In addition to test the activity of different toxins independently, we will also come up with a method to label and quantify the amount of toxins expressed in cells, and to compare the toxicity per unit between varies kinds of toxins.</p>
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<h5>Before you start: </h5>
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<p> Please read the following pages:</p>
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<ul>
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<li>  <a href="https://2016.igem.org/Requirements">Requirements page </a> </li>
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<li> <a href="https://2016.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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</ul>
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</div>
  
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<p>(3)Circuit design: We hope that the expression of antibiotic degrading enzyme and the TA module could be tightly regulated by signals outside. So in this part, we will utilize the tetracycline sensor constructed by BIT and make improvements to it by adding a positive feedback. We are also expected to further characterize this circuit. We will also test the TA module regulation circuit reported in some research papers.</p>
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<div class="highlight">
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<h5> Styling your wiki </h5>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>  
 
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<h5> Wiki template information </h5>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<h5> Editing your wiki </h5>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&action=edit"> Click here to edit this page! </a></p>
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</div>
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<h5>Tips</h5>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<ul>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2016.igem.org/Calendar">iGEM 2016 calendar</a> </li>
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<li>Have lots of fun! </li>
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</ul>
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</div>
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<h5>Inspiration</h5>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<ul>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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</ul>
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</div>
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<div class="column half_size" >
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<h5> Uploading pictures and files </h5>
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<p> You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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<div class="button_click"  onClick=" parent.location= 'https://2016.igem.org/Special:Upload '"> 
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UPLOAD FILES
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Revision as of 16:59, 28 June 2016

MENU ▤

Welcome to iGEM 2016!

Your team has been approved and you are ready to start the iGEM season!

Before you start:

Please read the following pages:

Styling your wiki

You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.

While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.

Wiki template information

We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!

Editing your wiki

On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!

Click here to edit this page!

Tips

This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:

  • State your accomplishments! Tell people what you have achieved from the start.
  • Be clear about what you are doing and how you plan to do this.
  • You have a global audience! Consider the different backgrounds that your users come from.
  • Make sure information is easy to find; nothing should be more than 3 clicks away.
  • Avoid using very small fonts and low contrast colors; information should be easy to read.
  • Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2016 calendar
  • Have lots of fun!
Inspiration

You can also view other team wikis for inspiration! Here are some examples:

Uploading pictures and files

You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to Team:YourOfficialTeamName/NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)

UPLOAD FILES