Difference between revisions of "Team:McMasterU"
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| − | <p> | + | <p>GI tract cancers are an enormous public health issue, and together are responsible for more deaths than any other form of cancer. One of the major difficulties with diagnosing and treating these cancers, especially when localized to the intestine, is access to the tumour - patients often do not exhibit obvious symptoms until the later stages, when treatment options are limited. |
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| + | We looked into a few different ways of tackling this issue, from improving existing diagnostic methods to developing new avenues for treatment. One of the consistent themes that came up in our brainstorming process was the potential for us to use the host's cell-mediated immune response to fight cancer. Cancer immunotherapy is a rapidly growing field, and clinical trials for certain forms of leukemia are already underway. | ||
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| + | Thus, this year, McMaster iGEM sought to augment the power of the host immune system to fight against GI tract cancers, using a specially engineered strain of commensal lactobacillus bacteria. When completed, our bacteria will be able to sense the presence of tumours in the gut, bind to specific receptors on tumour cells, and begin secreting pro-inflammatory cytokines in this tumour microenvironment. This will recruit T cells to the site of the tumour and elicit an anti-cancer response, effectively stopping the cancerous growth using the body's own toolkits. This summer, we aim to develop a proof-of-concept of our idea, and create a bacterial strain that can secrete IL-2 under tightly controlled, tumour-specific conditions</p> | ||
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Revision as of 02:52, 29 June 2016
Welcome to iGEM 2016!
Your team has been approved and you are ready to start the iGEM season!
Before you start:
Please read the following pages:
Styling your wiki
Project Description
GI tract cancers are an enormous public health issue, and together are responsible for more deaths than any other form of cancer. One of the major difficulties with diagnosing and treating these cancers, especially when localized to the intestine, is access to the tumour - patients often do not exhibit obvious symptoms until the later stages, when treatment options are limited. We looked into a few different ways of tackling this issue, from improving existing diagnostic methods to developing new avenues for treatment. One of the consistent themes that came up in our brainstorming process was the potential for us to use the host's cell-mediated immune response to fight cancer. Cancer immunotherapy is a rapidly growing field, and clinical trials for certain forms of leukemia are already underway. Thus, this year, McMaster iGEM sought to augment the power of the host immune system to fight against GI tract cancers, using a specially engineered strain of commensal lactobacillus bacteria. When completed, our bacteria will be able to sense the presence of tumours in the gut, bind to specific receptors on tumour cells, and begin secreting pro-inflammatory cytokines in this tumour microenvironment. This will recruit T cells to the site of the tumour and elicit an anti-cancer response, effectively stopping the cancerous growth using the body's own toolkits. This summer, we aim to develop a proof-of-concept of our idea, and create a bacterial strain that can secrete IL-2 under tightly controlled, tumour-specific conditions
Editing your wiki
On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!
Tips
This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:
- State your accomplishments! Tell people what you have achieved from the start.
- Be clear about what you are doing and how you plan to do this.
- You have a global audience! Consider the different backgrounds that your users come from.
- Make sure information is easy to find; nothing should be more than 3 clicks away.
- Avoid using very small fonts and low contrast colors; information should be easy to read.
- Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2016 calendar
- Have lots of fun!
Inspiration
You can also view other team wikis for inspiration! Here are some examples:
Uploading pictures and files
You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to Team:YourOfficialTeamName/NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)
