Difference between revisions of "Team:Dundee"

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    <title>Dundee 2016</title>
  
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<h2> Welcome to iGEM 2016! </h2>
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<h5>Before you start: </h5>
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<p> Please read the following pages:</p>
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<li>  <a href="https://2016.igem.org/Requirements">Requirements page </a> </li>
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<li> <a href="https://2016.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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<li> <a href="https://2016.igem.org/Resources/Template_Documentation"> Template Documentation </a></li>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>  
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<h5> Editing your wiki </h5>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&action=edit"> Click here to edit this page! </a></p>
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<h5>Tips</h5>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2016.igem.org/Calendar">iGEM 2016 calendar</a> </li>
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<li>Have lots of fun! </li>
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<h5>Inspiration</h5>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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<h5> Uploading pictures and files </h5>
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<p> You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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UPLOAD FILES
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  <a class="navbar-brand" style="color:#F5F12B;" href="#">Dundee iGEM 2016</a>
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<li><a style="color:#F5F12B;" href="#">Home <span class="sr-only">(current)</span></a></li>
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<li><a style="color:#F5F12B;" href="#">Team</a></li>
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<li><a style="color:#F5F12B;" href="#">Project</a></li>
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<li><a style="color:#F5F12B;" href="#">Parts</a></li>
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<li><a style="color:#F5F12B;" href="#">Attributions</a></li>
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<h1>Project Summary</h1>
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<p>Hello! We are the FBI (Fighting Bacterial Infections) team of Dundee and we are ready to present you our mission.</p>
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<p>The mission’s brainstorming process came from monthly meetings in which the team has come together and looked into previous projects and discussed potential products in the area of health, hygiene, pollution and farming. The choice of the final project came from a mutual agreement in which this project was identified as the most interesting and feasible, our iGEM team wanted to accept a challenging project which is achievable and thus will result in a good amount of data which can be modelled and displayed. Our project choice also has a wide public outreach option which is something other projects in the brainstorming sessions were lacking.</p>
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<p>Colicins are toxins released by bacteria which inhibit the growth of surrounding bacteria of the same or similar strains, enabling them to minimise their competition. We plan to harness this innate ability, targeting four different bacteria which can result in bacterial infections within the human gastro intestinal tract. This will include common causes of food poisoning such as E.coli, salmonella and shigella as well as helicobacter pylori which causes chronic inflammation of the stomach, potentially leading to ulcer formation and thus increased risk of stomach cancer.</p>
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<p>We plan to pinpoint the most specific bacteriocins for each of these bacteria and ligate them into E.coli, along with transcription promoting machinery which is activated at a low pH, so that production is only stimulated when the engineered E.coli reaches the stomach. This way target specificity can be achieved thus protecting the stomach microbes which are important for a healthy gut. With antibiotic resistance becoming a growing strain on public health, alternative treatment to bacterial infection is of increasing importance. This method could improve specificity of treatment while limiting the overuse of antibiotics. </p>
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<p>So far we have designed the colicins which we want to use and had them synthesised. Colicins have 3 domains, a receptor, translocation and toxic domain or warhead. We plan to alternate the toxic domains of the colicins to minimise the chance of resistance. We have identified alternative warheads for the colicins, picked promoters and selected some additional parts for our construct.</p>
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<p>Our iGEM team is aiming to create a universal biobrick useful for multiple applications. An alternative solution to relieve antibiotic over-usage. Fighting bacterial infections through harnessing bacteria’s innate ability to eliminate their competition. The vision is a marketable powdered product suitable for travel or home usage and useful for combatting bacterial infections of the human GI tract. Dundee’s FBI (Fighting Bacterial Infections) team are ready for action! </p>
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Revision as of 18:32, 30 June 2016

Dundee 2016

Project Summary

Hello! We are the FBI (Fighting Bacterial Infections) team of Dundee and we are ready to present you our mission.

The mission’s brainstorming process came from monthly meetings in which the team has come together and looked into previous projects and discussed potential products in the area of health, hygiene, pollution and farming. The choice of the final project came from a mutual agreement in which this project was identified as the most interesting and feasible, our iGEM team wanted to accept a challenging project which is achievable and thus will result in a good amount of data which can be modelled and displayed. Our project choice also has a wide public outreach option which is something other projects in the brainstorming sessions were lacking.

Colicins are toxins released by bacteria which inhibit the growth of surrounding bacteria of the same or similar strains, enabling them to minimise their competition. We plan to harness this innate ability, targeting four different bacteria which can result in bacterial infections within the human gastro intestinal tract. This will include common causes of food poisoning such as E.coli, salmonella and shigella as well as helicobacter pylori which causes chronic inflammation of the stomach, potentially leading to ulcer formation and thus increased risk of stomach cancer.

We plan to pinpoint the most specific bacteriocins for each of these bacteria and ligate them into E.coli, along with transcription promoting machinery which is activated at a low pH, so that production is only stimulated when the engineered E.coli reaches the stomach. This way target specificity can be achieved thus protecting the stomach microbes which are important for a healthy gut. With antibiotic resistance becoming a growing strain on public health, alternative treatment to bacterial infection is of increasing importance. This method could improve specificity of treatment while limiting the overuse of antibiotics.

So far we have designed the colicins which we want to use and had them synthesised. Colicins have 3 domains, a receptor, translocation and toxic domain or warhead. We plan to alternate the toxic domains of the colicins to minimise the chance of resistance. We have identified alternative warheads for the colicins, picked promoters and selected some additional parts for our construct.

Our iGEM team is aiming to create a universal biobrick useful for multiple applications. An alternative solution to relieve antibiotic over-usage. Fighting bacterial infections through harnessing bacteria’s innate ability to eliminate their competition. The vision is a marketable powdered product suitable for travel or home usage and useful for combatting bacterial infections of the human GI tract. Dundee’s FBI (Fighting Bacterial Infections) team are ready for action!