Difference between revisions of "Team:Exeter/Integrated Practices"

Line 668: Line 668:
 
                 <p id="pp">Dr Tom Ellis influenced the design of our kill switches by corroborating our theory that multiple kill switches in one system would reduce the error rate significantly - creating a fail safe, in the same way that broad spectrum antibiotics significantly reduces the chances of failure. We had planned on making an operon of KillerOrange and KillerRed, to both broaden the spectrum of light at which the reactive oxygen species are produced, but also significantly reduce the error rates of one. Dr Ellis argued that multiple kill switches in one system might have <q style="padding-left:0px;padding-right:0px;">less than one in a billion escape rates</q>.</p>
 
                 <p id="pp">Dr Tom Ellis influenced the design of our kill switches by corroborating our theory that multiple kill switches in one system would reduce the error rate significantly - creating a fail safe, in the same way that broad spectrum antibiotics significantly reduces the chances of failure. We had planned on making an operon of KillerOrange and KillerRed, to both broaden the spectrum of light at which the reactive oxygen species are produced, but also significantly reduce the error rates of one. Dr Ellis argued that multiple kill switches in one system might have <q style="padding-left:0px;padding-right:0px;">less than one in a billion escape rates</q>.</p>
 
                  
 
                  
                 <p id="pp">Due to time restraints with our project we decided to focus on providing significant analysis on the kill switches individually, however advice from Markus Geshater of Synthase Limited indicating that multiple kill switches in one system would be unfeasible and the different systems would need to be truly orthogonal to be effective. He explained that if in an industrial setting your synthetic system is producing a protein, then having one or multiple kill switches that are reliant on protein production would reduce the efficiency of production of your desired protein. Furthermore these kill switches could potentially be circumvented by the overexpression of a useful enzyme that is being commercially produced. Consequently, we felt assured in dropping the idea for a multiple kill switch system because our kill switches relied heavily on protein production and thus would reduce the efficiency of the product in an industrial setting. Instead of looking at multiple kill switches in the same system we looked to design three distinct kill switches to test and compare the efficiency of enzymatic, metabolic and DNA degrading mechanisms</p>
+
                 <p id="pp">Due to time restraints with our project we decided to focus on providing significant analysis on the kill switches individually, however advice from Markus Geshater of Synthase Limited indicating that multiple kill switches in one system would be unfeasible and the different systems would need to be truly orthogonal to be effective. He explained that if in an industrial setting your synthetic system is producing a protein, then having one or multiple kill switches that are reliant on protein production would reduce the efficiency of production of your desired protein. Furthermore these kill switches could potentially be circumvented by the overexpression of a useful enzyme that is being commercially produced. Consequently, we felt assured in dropping the idea for a multiple kill switch system because our kill switches relied heavily on protein production and thus would reduce the efficiency of the product in an industrial setting. Instead of looking at multiple kill switches in the same system we looked to design three distinct kill switches to test and compare the efficiency of enzymatic, metabolic and DNA degrading mechanisms</p>
  
 
<div class="row" style="padding-top:20px">
 
<div class="row" style="padding-top:20px">
Line 701: Line 701:
 
<h5>Background</h5>
 
<h5>Background</h5>
 
<p id="pp">
 
<p id="pp">
The fundamental reason for targeting equality and diversity within science, is that synthetic biology has the chance to be hierarchically and systematically equal from the beginning. If those working in the field can encourage the importance of diversity to younger generations, then when synthetic biology becomes more well recognised publicly as a field of science, it has the possibility of being known for its progressive nature towards gender, racial and socio-economical equality.  
+
The fundamental reason we have for targeting equality and diversity within science, is that synthetic biology has the chance to be hierarchically and systematically equal from the beginning. If those working in the field can encourage the importance of diversity to younger generations, then when synthetic biology becomes better recognised publicly as a field of science, it has the possibility of being known for its progressive nature towards gender, racial and socio-economical equality.  
 
</p>
 
</p>
 
<p id="pp">
 
<p id="pp">
We started our work on Equality and Diversity after we spoke to Dr Robert Smith of Kings College London, at the UK iGEM meetup in Westminster. He spoke to us about our progress with Human Practices and some the successes we have already had, however he emphasised that our idea for a study into diversity and equality in science had not really been performed, to his knowledge, at iGEM before. We therefore thought that we have the possibility of making a significant impact in the field by highlighting and addressing some of the issues surrounding a lack of gender equality and diversity in science overall.  
+
We started our work on Equality and Diversity after we spoke to Dr Robert Smith of Kings College London, at the UK iGEM meetup in Westminster. He spoke to us about our progress with Human Practices and some of the successes we had already had. He emphasised that our idea for a study into diversity and equality in science had not really been performed, to his knowledge, at iGEM before, much like our work on the importance of understanding what a kill switch is. We therefore thought that we have the possibility of making a significant impact in this field by highlighting and addressing some of the issues surrounding a lack of gender equality and diversity in science overall.  
 
<br />
 
<br />
The original plan was to create a short video highlighting the some of the issues surrounding a lack of gender equality in science and demonstrating what synthetic biology could do to address these wider issues. Dr Smith encouraged that we could look more broadly at diversity in science as well, emphasising that the problem doesn’t just stem from gender inequality, but also from a lack of diversity in terms of ethnicity, religion, disability and background.  
+
The original plan was to create a short video highlighting the some of the issues surrounding a lack of gender equality in science and demonstrating what could be done in synthetic biology to address these issues. Dr Smith encouraged us to look more broadly at diversity in science as well, emphasising that the problem doesn’t just stem from gender inequality, but also from a lack of diversity in terms of ethnicity, religion, disability and background.  
 
</p>
 
</p>
 
<p id="pp">
 
<p id="pp">
Line 766: Line 766:
 
</p>
 
</p>
 
<p id="pp">
 
<p id="pp">
On 24/08/16 we met with Dr Andrew Griffiths to talk about his role as the current Equality, Diversity and Inclusivity lead for Biosciences at the University and what he thinks could be done to improve these areas within the department. By talking to the point of contact to staff about these issues, we can understand what sort of issues are brought up recurringly, and what the university is doing to address these issues.  
+
On 24/08/16 we met with Dr Andrew Griffiths to talk about his role as the current Equality, Diversity and Inclusivity lead for Biosciences at the University and what he thinks could be done to improve these areas within the department. By talking to the point of contact to staff about these issues, we can understand what sort of recurring issues are brought up, and what the university is doing to address these issues.  
 
</p>
 
</p>
 
<h5>
 
<h5>
Line 786: Line 786:
 
</p>
 
</p>
 
<h5>
 
<h5>
<q style="margin:auto;display:block;"><i>Perhaps we should trying to promote paternity leave allowing flexibility for men to look after the children so the burden doesn’t fall on women all the time.</i></q>
+
<q style="margin:auto;display:block;"><i>Perhaps we should try to promote paternity leave allowing flexibility for men to look after the children so the burden doesn’t fall on women all the time.</i></q>
 
</h5>
 
</h5>
 
<p id="pp">
 
<p id="pp">
Line 831: Line 831:
 
</p>
 
</p>
 
<p id="pp">
 
<p id="pp">
Consequently, we are again led to question whether shared parental leave would relieve some of this pressure put on women? In fact, the ‘Swedish model’ of parental leave and balancing career with family commitments shows some very desirable qualities that employers would look for: ability to multitask (especially under pressure), commitment to career, etc. However, Dr Santos warned us about attributing the fact that fewer women are taking up jobs in higher up roles within Bioscience, to maternity leave - <q style="padding-left:0px;padding-right:0px;">Maternity is an easy excuse</q>.
+
We were again led to question whether shared parental leave would relieve some of this pressure put on women? In fact, the ‘Swedish model’ of parental leave and balancing career with family commitments shows some very desirable qualities that employers would look for: ability to multitask (especially under pressure), commitment to career, etc. However, Dr Santos warned us about attributing the fact that fewer women are taking up jobs in higher up roles within Bioscience to maternity leave - <q style="padding-left:0px;padding-right:0px;">Maternity is an easy excuse</q>.
 
</p>
 
</p>
 
<p id="pp">
 
<p id="pp">
Line 842: Line 842:
 
The need for supervisors to act as role models to young, aspiring post-docs is very apparent, especially as role models are so important for undergraduates and postgraduates, so why should this stop at levels beyond this?
 
The need for supervisors to act as role models to young, aspiring post-docs is very apparent, especially as role models are so important for undergraduates and postgraduates, so why should this stop at levels beyond this?
 
<br />
 
<br />
To conclude this meeting, we asked Dr Santos what she thinks needs to be done to improve gender equality in science and her response was thus:
+
To conclude this meeting, we asked Dr Santos what she thinks needs to be done to improve gender equality in science and her response was as follows:
 
</p>
 
</p>
 
<ul id="pp">
 
<ul id="pp">
Line 871: Line 871:
  
 
                 <h5>
 
                 <h5>
<q style="margin:auto;display:block;"><i>She would never make it in science unless she learnt to give a talk without sounding like a silly little school girl</i></q>
+
<q style="margin:auto;display:block;"><i>She would never make it in science unless she learns to give a talk without sounding like a silly little schoolgirl</i></q>
 
</h5>
 
</h5>
  
                 <p id="pp">This is shocking to think that a female role model would feel this is an appropriate comment for a nervous but aspiring young, female scientist. Dr Lewis argued that you could <q style="padding-left:0px;padding-right:0px;">never imagine a man being told he gave a bad talk because of a mannerism</q> and this kind of advice and influence has the potential to destroy all confidence in an individual.</p>
+
                 <p id="pp">It is shocking to think that a female role model would feel this is an appropriate comment for a nervous, but aspiring, young scientist. Dr Lewis argued that you could <q style="padding-left:0px;padding-right:0px;">never imagine a man being told he gave a bad talk because of a mannerism</q> and this kind of advice and influence has the potential to destroy all confidence in an individual.</p>
  
 
                 <p id="pp">Confidence is something Dr Lewis stressed needed addressing. In the initial interview with Dr Griffiths, he spoke of the difficulty in addressing womens’ confidence and how it might affect them applying to senior roles, however here, Dr Lewis argued that good role models and mentors are required throughout a student’s life to guide them in the right direction and to give them the confidence in their own abilities from the beginning.   
 
                 <p id="pp">Confidence is something Dr Lewis stressed needed addressing. In the initial interview with Dr Griffiths, he spoke of the difficulty in addressing womens’ confidence and how it might affect them applying to senior roles, however here, Dr Lewis argued that good role models and mentors are required throughout a student’s life to guide them in the right direction and to give them the confidence in their own abilities from the beginning.   
Line 883: Line 883:
 
</h5>
 
</h5>
  
                 <p id="pp">Considering the problems that we have heard from different academics at the university about establishing yourself in science as a woman, it is understandable why this in-built confidence in your own ability is very hard to attain. Interestingly Dr Lewis highlighted that there is an <q style="padding-left:0px;padding-right:0px;">ingrained difference</q> and that many academic situations are <q style="padding-left:0px;padding-right:0px;">built around the male world</q>. For example, presentations. She had observed many male tutees stand up and be naturally confident in their ability to talk in front of a crowd, however, she noted that it is more intimidating for the female tutees. Consequently, we have to consider if universities are doing enough to promote confidence in all students.</p>
+
                 <p id="pp">Considering the problems that we have heard from different academics at the university about establishing yourself in science as a woman, it is understandable why this in-built confidence in your own ability is very hard to attain. Interestingly Dr Lewis highlighted that there is a <q style="padding-left:0px;padding-right:0px;">ingrained difference</q> and that many academic situations are <q style="padding-left:0px;padding-right:0px;">built around the male world</q>. For example, presentations. She had observed many male tutees stand up and be naturally confident in their ability to talk in front of a crowd, however, she noted that it is more intimidating for the female tutees. Consequently, we have to consider if universities are doing enough to promote confidence in all students.</p>
  
 
                 <p id="pp">There was a statistic, highlighted by Dr Lewis, that if men and women were applying for the same job, the male candidates would tend to apply if they met 5 out of the 10 criteria whereas the female candidates would only apply if they had met 9 or all 10 criteria. Considering this, it seems that higher institutions are not doing enough to inspire confidence in all their students and there is this bias towards one gender.</p>
 
                 <p id="pp">There was a statistic, highlighted by Dr Lewis, that if men and women were applying for the same job, the male candidates would tend to apply if they met 5 out of the 10 criteria whereas the female candidates would only apply if they had met 9 or all 10 criteria. Considering this, it seems that higher institutions are not doing enough to inspire confidence in all their students and there is this bias towards one gender.</p>

Revision as of 14:44, 17 October 2016