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− | <div class="main ui citing justified container"> | + | <div class="main ui citing justified container"><h1 class = "ui centered dividing header"><span class="section"> </span>All parts</h1> |
+ | <div class = "ui segment"> | ||
+ | <p>Sonicell project introduces rapid cellular response to a combination of external stimuli like light, ultrasound or small molecules. Our system incorporates a | ||
+ | module for the enhanced sensitivity to ultrasound or other mechanical stimuli sensed by a calcium-dependent reporter. Furthermore we designed a module that can | ||
+ | combine several input signals in a novel signaling pathway/logic professing based on the collection of (split) orthogonal proteases. Those proteases can also cleave | ||
+ | the endoplasmic reticulum retention peptide segment, which results in a rapid secretion of proteins or peptides.</p> | ||
+ | <p>Our BioBrick submission, which this year consists of 52 parts, therefore represents a collection that covers the broad range the aforementioned tasks aimed to | ||
+ | function in mammalian cells, however many should also function in other types of a chassis. The parts can be divided into 4 collections based on their function: </p> | ||
+ | <p><ul> | ||
+ | <li> the collection of mechano- and ultrasound-sensing parts, | ||
+ | <li> the collection of orthogonal split and whole proteases with their reporters, | ||
+ | <li> the collection of parts for logic functions and | ||
+ | <li> the collection of parts for protease-triggered protein secretion. | ||
+ | </ul></p> | ||
+ | |||
+ | |||
+ | |||
+ | |||
+ | </div> | ||
</div> | </div> | ||
</div> | </div> |
Revision as of 13:43, 18 October 2016
All parts
Sonicell project introduces rapid cellular response to a combination of external stimuli like light, ultrasound or small molecules. Our system incorporates a module for the enhanced sensitivity to ultrasound or other mechanical stimuli sensed by a calcium-dependent reporter. Furthermore we designed a module that can combine several input signals in a novel signaling pathway/logic professing based on the collection of (split) orthogonal proteases. Those proteases can also cleave the endoplasmic reticulum retention peptide segment, which results in a rapid secretion of proteins or peptides.
Our BioBrick submission, which this year consists of 52 parts, therefore represents a collection that covers the broad range the aforementioned tasks aimed to function in mammalian cells, however many should also function in other types of a chassis. The parts can be divided into 4 collections based on their function:
- the collection of mechano- and ultrasound-sensing parts,
- the collection of orthogonal split and whole proteases with their reporters,
- the collection of parts for logic functions and
- the collection of parts for protease-triggered protein secretion.