Difference between revisions of "Team:BGIC China/Intellectual-Property"

(Created page with "{{BGIC_China}} <html itemscope itemtype='http://schema.org/WebPage' lang='zh-CN' xmlns:fb='https://www.facebook.com/2008/fbml' xmlns:og='http://ogp.me/ns#' xmlns='http://www.w...")
 
 
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{{BGIC_China}}
 
{{BGIC_China}}
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As the plasmids and genetic sequences of existing organisms are directly applied to the test paper based on cell-free system to allow the simulation of a real cell, the possibility of detection of almost any biological molecules is promised.\u003c/p\u003e\u003cp style=\"text-align: left;\"\u003e \u003c/p\u003e\u003cp style=\"text-align: left;\"\u003eOur test paper system also has a considerable precision in the testing of biological molecules in clinical samples. Via comprehensive modelling, the GFP and LacZ expression shown on the test paper is almost proportional to biological molecule presence of the sample. Therefore, not only could the product detect the presence of specific biological molecules, it could also shown the concentration of the substance through analysis by the plate reader we designed targeting at the measuring of GFP expression.\u003c/p\u003e\u003cp style=\"text-align: left;\"\u003e \u003c/p\u003e\u003cp style=\"text-align: left;\"\u003eA privilege to those with adequate Synthetic Biology, having purchased our protocol, they can reprogram the test paper system to perform other desired functions in the matter of weeks.\u003cbr\u003e \u003c/p\u003e\u003cp style=\"text-align: left;\"\u003eUnlike, laboratory equipments and devices, our test paper does not need external energy source to perform its function, it needs merely a 4 degree celsius environment——feasible in almost every household with a refrigerator, to be preserved for the better part of a year.\u003c/p\u003e\u003cp style=\"text-align: left;\"\u003e \u003c/p\u003e\u003cp style=\"text-align: left;\"\u003eThe test paper system, therefore, provided the presence of its features listed above, not only can it contribute greatly to the field of diagnostics, but also has irreplaceable market value and potential, once placed in mass production.\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1}]}}}],"title":"BBa_K2026001","uid":"24846828-31bd-4c9a-9e4f-b50c51eab288","path":"/bba-k2026001","autoPath":true},{"type":"Page","id":"f_8467524d-8496-4cfe-9355-07ce4940fd2d","defaultValue":null,"sections":[{"type":"Slide","id":"f_c2fc876b-fa12-48bd-b423-fd7d3ac6f016","defaultValue":null,"template_id":null,"template_name":"block","components":{"slideSettings":{"type":"SlideSettings","id":"f_3ede88b9-26d9-4cbd-af4c-e5a4aa1e6b38","defaultValue":null,"show_nav":true,"nameChanged":null,"name":"创建自己的","sync_key":null,"layout_variation":null,"display_settings":{}},"background1":{"type":"Background","id":"f_2f3e6d50-9813-4023-b68d-6d1faf7ff377","defaultValue":true,"url":"","textColor":"light","backgroundVariation":"","sizing":"cover","videoUrl":"","videoHtml":"","storageKey":null,"storage":null,"format":null,"h":null,"w":null,"s":null},"text1":{"type":"RichText","id":"f_cc7b7224-a4e0-49ce-b3b2-ae73963be46c","defaultValue":false,"value":"","backupValue":"","version":1},"text2":{"type":"RichText","id":"f_d7548db8-163d-460f-87f5-5416deccec84","defaultValue":false,"value":"","backupValue":"","version":1},"block1":{"type":"BlockComponent","id":"f_674574b2-fe26-4d19-a26e-70057d0dca74","defaultValue":null,"items":[{"type":"RichText","id":"f_72b54306-5be3-4ae9-a8ed-5eeab8b79970","defaultValue":false,"value":"\u003cp style=\"font-size: 160%;\"\u003e\u003ca target=\"_blank\" href=\"http://parts.igem.org/Part:BBa_K2026000\"\u003e\u003cstrong\u003ePart:BBa_K2026000\u003c/strong\u003e\u003c/a\u003e\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_530211ed-1035-48e2-81d2-212cf71fb39b","defaultValue":false,"value":"\u003cp style=\"font-size: 130%;\"\u003eLSSL, a composite part acts as genetic switch\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_83f78b2a-c50c-4144-9570-48f0b81e4ac0","defaultValue":false,"value":"\u003cp\u003e\u003cstrong\u003eBrief Introduction\u003c/strong\u003e\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_b232d282-44a6-428d-a774-22d23ec54117","defaultValue":false,"value":"\u003cp style=\"text-align: left;\"\u003eLSSL(LoxP-B0015-B0015-LoxP) is a composite part acts as genetic switch. 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Furthermore, with the combination of genetic sensor such as pCpxP or pFadR promoter, this part could function as a critical component in signal amplification system.\u003c/p\u003e\u003cp style=\"text-align: left;\"\u003e \u003c/p\u003e\u003cp style=\"text-align: left;\"\u003eThis part is flanked by standard biobrick restriction sites.\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_908b3866-d756-4fd2-8544-fd802daadf81","defaultValue":false,"value":"\u003cp\u003e\u003cstrong\u003eDetailed information \u003c/strong\u003e\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_4038945a-db81-43d2-8d68-767ae00bc366","defaultValue":false,"value":"\u003cp style=\"text-align: left;\"\u003eThe celebrated cre-loxp recombinase system, as many previous experiments and data suggests, is a widely used technology in DNA sequence modification. 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(e.g. BBa_K1021005, BBa_K1179058, BBa_K1440000, IGEM parts) In our design, we focused on the appropriate arrangement of loxp sites thus achieve our goal – amplify the signal produced my inductive expression.\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_75f7af21-3e12-4e79-98b0-baf207766d0f","defaultValue":false,"value":"\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eDesign:\u003c/strong\u003e\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_29f106fd-ce70-41ff-b5b9-03f31d396538","defaultValue":false,"value":"\u003cp style=\"text-align: left;\"\u003eBased on the fact that ‘It has already been established that the loxP site exhibits directionality. When two sites on the same DNA molecule are in a directly repeated orientation, the DNA between the sites is excised after recombination’ (Hoess 1984) After several premature design, we designed the amplification plasmid PET28a-L-S-L-LacZW-Cre, once there’s Cre recombinase presented within the system, the two same oriented loxp sites flanking two B0015 terminators, would recombine thus results in deletion of the terminators thus enables the downstream expression. Furthermore, once the terminators have been removed while downstream LacZ reporter starts to express, the downstream Cre sequence would also express thus result in even higher level of Cre recombinase, which promotes removal of the terminators, amplify the signal with superb efficiency within a fairly short time.\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_7d54b6e5-db42-4de4-a2aa-1e6003db19f8","defaultValue":false,"value":"\u003cp\u003e\u003cem\u003eReferences:\u003c/em\u003e\u003c/p\u003e\u003cp\u003e \u003c/p\u003e\u003cp style=\"text-align: left;\"\u003e\u003cem\u003e1. Hoess, Ronald H., and Ken Abremski. \"Interaction of the bacteriophage P1 recombinase Cre with the recombining site loxP.\" Proceedings of the National Academy of Sciences 81.4 (1984): 1026-1029.\u003cbr\u003e2. Sternberg, Nat, and Daniel Hamilton. \"Bacteriophage P1 site-specific recombination: I. 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Furthermore, with the combination of genetic sensor such as pCpxP or pFadR promoter, this part could function as a critical component in signal amplification system.\u003c/p\u003e\u003cp style=\"text-align: left;\"\u003e \u003c/p\u003e\u003cp style=\"text-align: left;\"\u003eThis part is flanked by standard biobrick restriction sites.\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_908b3866-d756-4fd2-8544-fd802daadf81","defaultValue":false,"value":"\u003cp\u003e\u003cstrong\u003eDetailed information \u003c/strong\u003e\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_4038945a-db81-43d2-8d68-767ae00bc366","defaultValue":false,"value":"\u003cp style=\"text-align: left;\"\u003eThe celebrated cre-loxp recombinase system, as many previous experiments and data suggests, is a widely used technology in DNA sequence modification. 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(e.g. BBa_K1021005, BBa_K1179058, BBa_K1440000, IGEM parts) In our design, we focused on the appropriate arrangement of loxp sites thus achieve our goal – amplify the signal produced my inductive expression.\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_75f7af21-3e12-4e79-98b0-baf207766d0f","defaultValue":false,"value":"\u003cp style=\"text-align: left;\"\u003e\u003cstrong\u003eDesign:\u003c/strong\u003e\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_29f106fd-ce70-41ff-b5b9-03f31d396538","defaultValue":false,"value":"\u003cp style=\"text-align: left;\"\u003eBased on the fact that ‘It has already been established that the loxP site exhibits directionality. When two sites on the same DNA molecule are in a directly repeated orientation, the DNA between the sites is excised after recombination’ (Hoess 1984) After several premature design, we designed the amplification plasmid PET28a-L-S-L-LacZW-Cre, once there’s Cre recombinase presented within the system, the two same oriented loxp sites flanking two B0015 terminators, would recombine thus results in deletion of the terminators thus enables the downstream expression. Furthermore, once the terminators have been removed while downstream LacZ reporter starts to express, the downstream Cre sequence would also express thus result in even higher level of Cre recombinase, which promotes removal of the terminators, amplify the signal with superb efficiency within a fairly short time.\u003c/p\u003e","backupValue":"在此处添加文本段落。","version":1},{"type":"RichText","id":"f_7d54b6e5-db42-4de4-a2aa-1e6003db19f8","defaultValue":false,"value":"\u003cp\u003e\u003cem\u003eReferences:\u003c/em\u003e\u003c/p\u003e\u003cp\u003e \u003c/p\u003e\u003cp style=\"text-align: left;\"\u003e\u003cem\u003e1. Hoess, Ronald H., and Ken Abremski. \"Interaction of the bacteriophage P1 recombinase Cre with the recombining site loxP.\" Proceedings of the National Academy of Sciences 81.4 (1984): 1026-1029.\u003cbr\u003e2. Sternberg, Nat, and Daniel Hamilton. \"Bacteriophage P1 site-specific recombination: I. 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</script> <!--[if lte IE 9]><script src="//assets.strikingly.com/assets/detectIE-b0fc7986f8eb7d40a31e9582bdeb7b88.js"></script><![endif]--> </head> <body class='show locale-zh-CN' id='user_sites'> <div id="s-page-container"><div data-reactroot="" data-reactid="1" data-react-checksum="-1805621151"><!-- react-empty: 2 --><div id="s-content" class="s-variation-default s-font-heading-roboto s-font-title-roboto s-font-body-default s-entrance-mask" data-reactid="3"><div class="social-thumbnail" data-reactid="4"><div style="display:none;" data-reactid="5"><img src="//assets.strikingly.com/assets/fb_images/default-715654470f8f9a657474bf68cefc382f.png" alt="page thumbnail" width="300" height="300" data-reactid="6"/></div><div id="lw-share-data" style="display:none;" data-reactid="7"><div class="lws-title" data-reactid="8">Ellz&#x27;s Site Copy</div><div class="lws-description" data-reactid="9">Website</div><div class="lws-image" data-reactid="10">http://assets.strikingly.com/assets/fb_images/default-715654470f8f9a657474bf68cefc382f.png</div></div></div><!-- react-empty: 11 --><!-- react-empty: 12 --><ul class="slides s-page-1" data-reactid="13"><li class="slide s-section-1" id="section-f_20166aee-2a08-4027-ac4f-3fd35942543a" data-reactid="14"><div class="waypoint" data-reactid="15"></div><a class="section-anchor" data-reactid="16"></a><div class="lazyload s-no-bg s-block-section s-section" data-reactid="17"><div class="container" data-reactid="18"><div class="columns sixteen" data-reactid="19"><!-- react-empty: 20 --></div><div class="alignment-container " data-reactid="21"><div class="s-repeatable s-block s-component s-mh " data-reactid="22"><div class="s-block-item s-repeatable-item s-block-sortable-item " data-reactid="23"><span data-reactid="24"><div data-reactid="25"><div class="s-block-item-inner clearfix" style="position:relative;" data-reactid="26"><div class=" columns sixteen" data-reactid="27"><div class="s-component s-text" data-reactid="28"><div class="s-component-content s-font-body" data-reactid="29"><p><strong>A proposal of BGI-college team concerning intellectual Property</strong></p></div></div></div></div></div></span></div><div class="s-block-item s-repeatable-item s-block-sortable-item " data-reactid="30"><span data-reactid="31"><div data-reactid="32"><div class="s-block-item-inner clearfix" style="position:relative;" data-reactid="33"><div class=" columns sixteen" data-reactid="34"><div class="s-component s-text" data-reactid="35"><div class="s-component-content s-font-body" data-reactid="36"><p style="text-align: left;">Upon the finishing of our product, with full realisation of its value as a programmable and opensource paper-based testing platform based on cell-free system, we believe in the potential of this project to contribute in the field of diagnostics specifying in clinical sample tests that are free from the limitation of laboratory work.</p><p style="text-align: left;"> </p><p style="text-align: left;">First, the open-source nature of the test paper system allows and encourages those with adequate knowledge and techniques specialised in the field of Synthetic Biology to reprogram the sensor plasmid of our test-paper system, giving unlimited potential of the variety and capacity of the number of test papers of different functionality to be designed, manufactured and put into practice and hereby satisfying tremendous demands for specified biological substance detection involved in clinical and diagnostic tasks.</p><p style="text-align: left;"> </p><p style="text-align: left;">Also, being based on cell-free system, comprehensive limitations of biochemical reactions, for example, the fatality to the cell due to the toxicity of the product of metabolism and the prospect of the plasmid being controlled by the host due to negative feedback. A cell-free system has relatively higher operability, proved to be a better alternative for DNA transcription and expression. Moreover, having mitigated and minimised ethical issues involving the exploitation of living organisms, the product is excepted to be accepted much more widely in the global market, leading to higher demands, and in extension, sales volume and shelf live——in plain English, higher success in the market.</p><p style="text-align: left;"> </p><p style="text-align: left;">The bionic nature, too, contribute immensely to the project’s compatibility to a wider range of samples. As the plasmids and genetic sequences of existing organisms are directly applied to the test paper based on cell-free system to allow the simulation of a real cell, the possibility of detection of almost any biological molecules is promised.</p><p style="text-align: left;"> </p><p style="text-align: left;">Our test paper system also has a considerable precision in the testing of biological molecules in clinical samples. Via comprehensive modelling, the GFP and LacZ expression shown on the test paper is almost proportional to biological molecule presence of the sample. Therefore, not only could the product detect the presence of specific biological molecules, it could also shown the concentration of the substance through analysis by the plate reader we designed targeting at the measuring of GFP expression.</p><p style="text-align: left;"> </p><p style="text-align: left;">A privilege to those with adequate Synthetic Biology, having purchased our protocol, they can reprogram the test paper system to perform other desired functions in the matter of weeks.<br> </p><p style="text-align: left;">Unlike, laboratory equipments and devices, our test paper does not need external energy source to perform its function, it needs merely a 4 degree celsius environment——feasible in almost every household with a refrigerator, to be preserved for the better part of a year.</p><p style="text-align: left;"> </p><p style="text-align: left;">The test paper system, therefore, provided the presence of its features listed above, not only can it contribute greatly to the field of diagnostics, but also has irreplaceable market value and potential, once placed in mass production.</p></div></div></div></div></div></span></div></div></div></div></div></li></ul><!-- react-empty: 37 --><div id="strikingly-tooltip-container" data-reactid="38"> </div><!-- react-empty: 39 --><!-- react-empty: 40 --><div class="s-floated-components" data-reactid="41"><div class="ecommerce-buy-dialog s-edit-modal extend" id="ecommerce-buy-dialog" data-reactid="42"><div class="s-async-wrapper s-component" data-reactid="43"><div class="s-loading" data-reactid="44"></div></div></div><div id="s-ecommerce-shopping-cart-wrapper" class="s-ecommerce-shopping-cart-wrapper" data-reactid="45"></div></div></div></div></div> <div id='fb-root'></div> <div id='app-script-root'></div> <div id='app-view-root'></div> <script id='blog-collection-tmpl' type='text/html'> <div class='s-blog-col-head'></div> <div class='s-blog-col-body'> {{ _.each(blogPosts, function(blog) { }} <div class='s-blog-entry'> <div class='s-blog-entry-inner'> {{ if ($S && $S.conf && $S.conf.preview_mode) { }} <a class='s-blog-overlay-link' href='{{=blog.publicUrl}}'>&nbsp;</a> {{ } else { }} <a class='s-blog-overlay-link' href='{{=blog.relativeUrl}}'>&nbsp;</a> {{ } }} {{ if (blog.iconUrl) { }} <div class='s-blog-entry-left'> {{ if (UrlHelper.imageHasContent(blog.iconUrl)) { }} <div class='s-blog-avatar' style='background-image:url({{=blog.iconUrl}});'></div> {{ } else { }} <div class='s-blog-default-avatar'> <div class='entypo-bookmark'></div> </div> {{ } }} </div> {{ } }} <div class='s-blog-entry-right'> <div class='s-blog-details'> <div class='s-blog-details-head s-blog-row'> <div class='s-blog-title s-font-heading'> {{=blog.title}} </div> <div class='s-blog-date'> {{=blog.publishedAt}} </div> </div> {{ if (blogSettings.previewLayout == 1) { }} <div class='s-blog-details-blurb s-blog-row'> {{=blog.blurb}} </div> {{ } }} </div> </div> </div> </div> {{ }) }} {{ if (blogPosts.length == 0) { }} <div class='s-blog-entry'> <div class='s-common-status no-posts-error'> 没有博文。 </div> </div> {{ } }} </div> {{ if (blogPosts.length > 0) { }} <div class='s-blog-col-foot'> <a class='s-blog-link s-blog-next-link' href='javascript:void(0);'> &laquo; 更新 </a> &nbsp; <ul class='s-blog-pagination' style='display:none;'> <li> <a class='s-blog-link s-blog-pagination-page' href='javascript:void(0);'></a> </li> </ul> &nbsp; <a class='s-blog-link s-blog-prev-link' href='javascript:void(0);'> 其它 &raquo; </a> </div> {{ } }} </script> <script src="//cdn.bootcss.com/jquery/1.10.0/jquery.min.js"></script> <script>
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</script> <!--[if lte IE 9]><script src="//assets.strikingly.com/assets/detectIE-b0fc7986f8eb7d40a31e9582bdeb7b88.js"></script><![endif]--> </head> <body class='show locale-zh-CN' id='user_sites'> <div id="s-page-container"><div data-reactroot="" data-reactid="1" data-react-checksum="-836799521"><!-- react-empty: 2 --><div id="s-content" class="s-variation-default s-font-heading-roboto s-font-title-roboto s-font-body-default s-entrance-mask" data-reactid="3"><div class="social-thumbnail" data-reactid="4"><div style="display:none;" data-reactid="5"><img src="//assets.strikingly.com/assets/fb_images/default-715654470f8f9a657474bf68cefc382f.png" alt="page thumbnail" width="300" height="300" data-reactid="6"/></div><div id="lw-share-data" style="display:none;" data-reactid="7"><div class="lws-title" data-reactid="8">Ellz&#x27;s Site Copy</div><div class="lws-description" data-reactid="9">Website</div><div class="lws-image" data-reactid="10">http://assets.strikingly.com/assets/fb_images/default-715654470f8f9a657474bf68cefc382f.png</div></div></div><!-- react-empty: 11 --><!-- react-empty: 12 --><ul class="slides s-page-1" data-reactid="13"><li class="slide s-section-1" id="section-f_20166aee-2a08-4027-ac4f-3fd35942543a" data-reactid="14"><div class="waypoint" data-reactid="15"></div><a class="section-anchor" data-reactid="16"></a><div class="lazyload s-no-bg s-block-section s-section" data-reactid="17"><div class="container" data-reactid="18"><div class="columns sixteen" data-reactid="19"><!-- react-empty: 20 --></div><div class="alignment-container " data-reactid="21"><div class="s-repeatable s-block s-component s-mh " data-reactid="22"><div class="s-block-item s-repeatable-item s-block-sortable-item " data-reactid="23"><span data-reactid="24"><div data-reactid="25"><div class="s-block-item-inner clearfix" style="position:relative;" data-reactid="26"><div class=" columns sixteen" data-reactid="27"><div class="s-component s-text" data-reactid="28"><div class="s-component-content s-font-body" data-reactid="29"><p><strong>A proposal of BGI-college team concerning intellectual Property</strong></p></div></div></div></div></div></span></div><div class="s-block-item s-repeatable-item s-block-sortable-item " data-reactid="30"><span data-reactid="31"><div data-reactid="32"><div class="s-block-item-inner clearfix" style="position:relative;" data-reactid="33"><div class=" columns sixteen" data-reactid="34"><div class="s-component s-text" data-reactid="35"><div class="s-component-content s-font-body" data-reactid="36"><p style="text-align: left;">Upon the finishing of our product, with full realisation of its value as a programmable and opensource paper-based testing platform based on cell-free system, we believe in the potential of this project to contribute in the field of diagnostics specifying in clinical sample tests that are free from the limitation of laboratory work.</p><p style="text-align: left;"> </p><p style="text-align: left;">First, the open-source nature of the test paper system allows and encourages those with adequate knowledge and techniques specialised in the field of Synthetic Biology to reprogram the sensor plasmid of our test-paper system, giving unlimited potential of the variety and capacity of the number of test papers of different functionality to be designed, manufactured and put into practice and hereby satisfying tremendous demands for specified biological substance detection involved in clinical and diagnostic tasks.</p><p style="text-align: left;"> </p><p style="text-align: left;">Also, being based on cell-free system, comprehensive limitations of biochemical reactions, for example, the fatality to the cell due to the toxicity of the product of metabolism and the prospect of the plasmid being controlled by the host due to negative feedback. A cell-free system has relatively higher operability, proved to be a better alternative for DNA transcription and expression. Moreover, having mitigated and minimised ethical issues involving the exploitation of living organisms, the product is excepted to be accepted much more widely in the global market, leading to higher demands, and in extension, sales volume and shelf live——in plain English, higher success in the market.</p><p style="text-align: left;"> </p><p style="text-align: left;">The bionic nature, too, contribute immensely to the project’s compatibility to a wider range of samples. As the plasmids and genetic sequences of existing organisms are directly applied to the test paper based on cell-free system to allow the simulation of a real cell, the possibility of detection of almost any biological molecules is promised.</p><p style="text-align: left;"> </p><p style="text-align: left;">Our test paper system also has a considerable precision in the testing of biological molecules in clinical samples. Via comprehensive modelling, the GFP and LacZ expression shown on the test paper is almost proportional to biological molecule presence of the sample. Therefore, not only could the product detect the presence of specific biological molecules, it could also shown the concentration of the substance through analysis by the plate reader we designed targeting at the measuring of GFP expression.</p><p style="text-align: left;"> </p><p style="text-align: left;">A privilege to those with adequate Synthetic Biology, having purchased our protocol, they can reprogram the test paper system to perform other desired functions in the matter of weeks.<br> </p><p style="text-align: left;">Unlike, laboratory equipments and devices, our test paper does not need external energy source to perform its function, it needs merely a 4 degree celsius environment——feasible in almost every household with a refrigerator, to be preserved for the better part of a year.</p><p style="text-align: left;"> </p><p style="text-align: left;">The test paper system, therefore, provided the presence of its features listed above, not only can it contribute greatly to the field of diagnostics, but also has irreplaceable market value and potential, once placed in mass production.</p></div></div></div></div></div></span></div></div></div></div></div></li></ul><!-- react-empty: 37 --><div id="strikingly-tooltip-container" data-reactid="38"> </div><!-- react-empty: 39 --><!-- react-empty: 40 --><div class="s-floated-components" data-reactid="41"><div class="ecommerce-buy-dialog s-edit-modal extend" id="ecommerce-buy-dialog" data-reactid="42"><div class="s-async-wrapper s-component" data-reactid="43"><div class="s-loading" data-reactid="44"></div></div></div><div id="s-ecommerce-shopping-cart-wrapper" class="s-ecommerce-shopping-cart-wrapper" data-reactid="45"></div></div></div></div></div> <div id='fb-root'></div> <div id='app-script-root'></div> <div id='app-view-root'></div> <script id='blog-collection-tmpl' type='text/html'> <div class='s-blog-col-head'></div> <div class='s-blog-col-body'> {{ _.each(blogPosts, function(blog) { }} <div class='s-blog-entry'> <div class='s-blog-entry-inner'> {{ if ($S && $S.conf && $S.conf.preview_mode) { }} <a class='s-blog-overlay-link' href='{{=blog.publicUrl}}'>&nbsp;</a> {{ } else { }} <a class='s-blog-overlay-link' href='{{=blog.relativeUrl}}'>&nbsp;</a> {{ } }} {{ if (blog.iconUrl) { }} <div class='s-blog-entry-left'> {{ if (UrlHelper.imageHasContent(blog.iconUrl)) { }} <div class='s-blog-avatar' style='background-image:url({{=blog.iconUrl}});'></div> {{ } else { }} <div class='s-blog-default-avatar'> <div class='entypo-bookmark'></div> </div> {{ } }} </div> {{ } }} <div class='s-blog-entry-right'> <div class='s-blog-details'> <div class='s-blog-details-head s-blog-row'> <div class='s-blog-title s-font-heading'> {{=blog.title}} </div> <div class='s-blog-date'> {{=blog.publishedAt}} </div> </div> {{ if (blogSettings.previewLayout == 1) { }} <div class='s-blog-details-blurb s-blog-row'> {{=blog.blurb}} </div> {{ } }} </div> </div> </div> </div> {{ }) }} {{ if (blogPosts.length == 0) { }} <div class='s-blog-entry'> <div class='s-common-status no-posts-error'> 没有博文。 </div> </div> {{ } }} </div> {{ if (blogPosts.length > 0) { }} <div class='s-blog-col-foot'> <a class='s-blog-link s-blog-next-link' href='javascript:void(0);'> &laquo; 更新 </a> &nbsp; <ul class='s-blog-pagination' style='display:none;'> <li> <a class='s-blog-link s-blog-pagination-page' href='javascript:void(0);'></a> </li> </ul> &nbsp; <a class='s-blog-link s-blog-prev-link' href='javascript:void(0);'> 其它 &raquo; </a> </div> {{ } }} </script> <script src="//cdn.bootcss.com/jquery/1.10.0/jquery.min.js"></script> <script>
 
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Latest revision as of 18:24, 18 October 2016

Ellz's Site Copy

  • A proposal of BGI-college team concerning intellectual Property

    Upon the finishing of our product, with full realisation of its value as a programmable and opensource paper-based testing platform based on cell-free system, we believe in the potential of this project to contribute in the field of diagnostics specifying in clinical sample tests that are free from the limitation of laboratory work.

    First, the open-source nature of the test paper system allows and encourages those with adequate knowledge and techniques specialised in the field of Synthetic Biology to reprogram the sensor plasmid of our test-paper system, giving unlimited potential of the variety and capacity of the number of test papers of different functionality to be designed, manufactured and put into practice and hereby satisfying tremendous demands for specified biological substance detection involved in clinical and diagnostic tasks.

    Also, being based on cell-free system, comprehensive limitations of biochemical reactions, for example, the fatality to the cell due to the toxicity of the product of metabolism and the prospect of the plasmid being controlled by the host due to negative feedback. A cell-free system has relatively higher operability, proved to be a better alternative for DNA transcription and expression. Moreover, having mitigated and minimised ethical issues involving the exploitation of living organisms, the product is excepted to be accepted much more widely in the global market, leading to higher demands, and in extension, sales volume and shelf live——in plain English, higher success in the market.

    The bionic nature, too, contribute immensely to the project’s compatibility to a wider range of samples. As the plasmids and genetic sequences of existing organisms are directly applied to the test paper based on cell-free system to allow the simulation of a real cell, the possibility of detection of almost any biological molecules is promised.

    Our test paper system also has a considerable precision in the testing of biological molecules in clinical samples. Via comprehensive modelling, the GFP and LacZ expression shown on the test paper is almost proportional to biological molecule presence of the sample. Therefore, not only could the product detect the presence of specific biological molecules, it could also shown the concentration of the substance through analysis by the plate reader we designed targeting at the measuring of GFP expression.

    A privilege to those with adequate Synthetic Biology, having purchased our protocol, they can reprogram the test paper system to perform other desired functions in the matter of weeks.

    Unlike, laboratory equipments and devices, our test paper does not need external energy source to perform its function, it needs merely a 4 degree celsius environment——feasible in almost every household with a refrigerator, to be preserved for the better part of a year.

    The test paper system, therefore, provided the presence of its features listed above, not only can it contribute greatly to the field of diagnostics, but also has irreplaceable market value and potential, once placed in mass production.