Difference between revisions of "Team:Exeter/Integrated Practices"

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<h1 id="title">Integrated: Equality and Diversity</h1>
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<a href="https://2016.igem.org/Team:Exeter/Integrated_Practices/lab" class="banner_link col-xs-6"><span class="oneline">Integrated: Kill Switch</span></a>
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<a href="https://2016.igem.org/Team:Exeter/Integrated_Practices/E&D" class="banner_link col-xs-6"><span class="oneline">Integrated: Equality and Diversity</span></a>
 
 
 
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Overview
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Lab intergration
 
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<h6>Lab Integration:</h6>
 
                  
 
                  
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                 <p id="pp">We approached our Integrated Human Practices from two perspectives: the traditional, integrating the
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                 <p id="pp">By interviewing academic and industry researchers about their understanding of kill switches, we could analyse whether they are effective biosafety mechanisms and if they are appropriate for use in either industry or academic research.</p>
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Human Practices into the lab project; and the unconventional, integrating the human practices into itself.
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We thought we could make the biggest impact in both Human Practices and the lab if we provided cohesive, reassured arguments
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                <p id="pp">Dr Tom Ellis influenced the design of our kill switches by corroborating our theory that multiple kill switches in one system would reduce the error rate significantly - creating a fail safe, in the same way that broad spectrum antibiotics significantly reduces the chances of failure. We had planned on making an operon of KillerOrange and KillerRed, to both broaden the spectrum of light at which the reactive oxygen species are produced, but also significantly reduce the error rates of one. Dr Ellis argued that multiple kill switches in one system might have <q style="padding-left:0px;padding-right:0px;">less than one in a billion escape rates</q>.</p>
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                <p id="pp">Due to time restraints with our project we decided to focus on providing significant analysis on the kill switches individually, however advice from Markus Geshater of Synthase Limited indicating that multiple kill switches in one system would be unfeasible and the different systems would need to be truly orthogonal to be effective. He explained that if in an industrial setting your synthetic system is producing a protein, then having one or multiple kill switches that are reliant on protein production would reduce the efficiency of production of your desired protein. Furthermore these kill switches could potentially be circumvented by the overexpression of a useful enzyme that is being commercially produced.  Consequently, we felt assured in dropping the idea for a multiple kill switch system because our kill switches relied heavily on protein production and thus would reduce the efficiency of the product in an industrial setting. Instead of looking at multiple kill switches in the same system we looked to design three distinct kill switches to test and compare the efficiency of enzymatic, metabolic and DNA degrading mechanisms</p>
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Does sexism in science exist?
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Student opinions
 
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<h6>Outreach Integration:</h6>
 
                  
 
                  
 
                 <p id="pp">We have extensive public engagement and education work in our Human Practices section. We focused early on how to best to influence the public in both lower and higher education with regards to engaging and understanding synthetic biology. For the equality and diversity section of the Human Practices, we needed to created a well reasoned and grounded project, which both highlights the work of academics at the university and shapes more educated opinions on equality and diversity in science. Consequently, we aimed to integrate each individual interview into the next, drawing from ideas from previous interviews, so we could properly discuss the problem of gender inequality and the issues raised by both academics and students. We found this to be the best way to create a discussion between the academics as they are providing analysis and personal insight on the opinion based on their experiences and the experiences of the previous academics. This approach also allowed us to discuss in depth issues such as the problems associated with maternity and paternity leave in science and whether there is a need for massive social and structural change.</p>
 
                 <p id="pp">We have extensive public engagement and education work in our Human Practices section. We focused early on how to best to influence the public in both lower and higher education with regards to engaging and understanding synthetic biology. For the equality and diversity section of the Human Practices, we needed to created a well reasoned and grounded project, which both highlights the work of academics at the university and shapes more educated opinions on equality and diversity in science. Consequently, we aimed to integrate each individual interview into the next, drawing from ideas from previous interviews, so we could properly discuss the problem of gender inequality and the issues raised by both academics and students. We found this to be the best way to create a discussion between the academics as they are providing analysis and personal insight on the opinion based on their experiences and the experiences of the previous academics. This approach also allowed us to discuss in depth issues such as the problems associated with maternity and paternity leave in science and whether there is a need for massive social and structural change.</p>
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                 <p id="pp">Overall, we have examined the work of academics at this university who attempt to improve equality and diversity, at their different levels, in science. They have greatly informed us on the problems with gender inequality as well as how the university is, and plans on tackling the problem. </p>
 
                 <p id="pp">Overall, we have examined the work of academics at this university who attempt to improve equality and diversity, at their different levels, in science. They have greatly informed us on the problems with gender inequality as well as how the university is, and plans on tackling the problem. </p>
  
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<h5>What is ‘diversity’?</h5>
 
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<h5>The Gender Study - A Future Project</h5>
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              <h5>The Gender Study - A Future Project</h5>
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Paris Bettencourt in 2013 provided a detailed study of gender distribution in synthetic biology and iGEM. They found that women were not as represented as men within iGEM and equally there were fewer female supervisors of iGEM teams. They provided data to suggest that there is a significantly higher proportion of women to men in teams that win prizes compared with teams that don’t. They concluded their study with suggestions of how to improve the gender distribution within synthetic biology and iGEM, proposing that bonus points could given to teams with female supervisors, and iGEM should promote larger teams with more female judges, in the hope that this would improve the gender distribution within teams.
 
Paris Bettencourt in 2013 provided a detailed study of gender distribution in synthetic biology and iGEM. They found that women were not as represented as men within iGEM and equally there were fewer female supervisors of iGEM teams. They provided data to suggest that there is a significantly higher proportion of women to men in teams that win prizes compared with teams that don’t. They concluded their study with suggestions of how to improve the gender distribution within synthetic biology and iGEM, proposing that bonus points could given to teams with female supervisors, and iGEM should promote larger teams with more female judges, in the hope that this would improve the gender distribution within teams.
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Due to time restraints, we will be unable to undertake this follow-up gender study, however we challenge future iGEM teams, who struggle with Human Practices, to look at the impact they could make locally and nationally in equality and diversity, and perform a follow up study to Paris Bettencourt’s from 2013. We believe that iGEM teams have a fantastic opportunity to make a significant difference in this area by highlighting the work of academics and researchers at their university working to achieve greater equality, diversity and inclusivity in their field of science, or in science as a whole. We also challenge iGEM to look more at ways of improving and encouraging greater diversity, so that synthetic biology can be recognised as a positive, progressive field of science and one that acts as a representative to the individual core subjects that make up it.
 
Due to time restraints, we will be unable to undertake this follow-up gender study, however we challenge future iGEM teams, who struggle with Human Practices, to look at the impact they could make locally and nationally in equality and diversity, and perform a follow up study to Paris Bettencourt’s from 2013. We believe that iGEM teams have a fantastic opportunity to make a significant difference in this area by highlighting the work of academics and researchers at their university working to achieve greater equality, diversity and inclusivity in their field of science, or in science as a whole. We also challenge iGEM to look more at ways of improving and encouraging greater diversity, so that synthetic biology can be recognised as a positive, progressive field of science and one that acts as a representative to the individual core subjects that make up it.
 
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Revision as of 19:35, 19 October 2016