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The Universal Scaffold
In the emerging field of synthetic biology, many new innovations arise. To use them as efficient and safe as possible, regulation is the key. Therefore, iGEM TU Eindhoven is developing new kinds of scaffold proteins, based on 14-3-3 proteins. These scaffold proteins have a wide range of applications in nature and utilizing this feature they are used to regulate systems in synthetic biology.
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The Team
The iGEM 2016 team of the Eindhoven University of Technology consists of 9 enthusiastic undergraduates of both Biomedical Engineering and Medical Sciences and Technology. Our members work very hard both inside and outside the lab, and have a great time working on our project and learn a lot thanks to iGEM.
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The Model
In order to create our heterodimeric scaffold it is essential to find suitable mutations to create a mutated T14-3-3/CT52 pair that is orthogonal to the wildtype. To find these mutations, The Rosetta software and a self-written protocol was used,
To determine the yet unknown properties of our newly designed pairs, a model based on Mass-Action and Michaelis-Menten kinetics was developed.
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Human Practices
Hello this is slide one of the interactive slideshow. This is some text to see how the code works. It needs to be a bit longer. Still a bit longer, like way way way way longer.....
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The Results
Hello this is slide one of the interactive slideshow. This is some text to see how the code works. It needs to be a bit longer. Still a bit longer, like way way way way longer.....
Hier nog meer tekst met ergens een linkje of een soort button knop om door te gaan naar die pagina. niet zo'n lelijke zoals bij de vorige pagina.. beetje mooier, zal er nog is naar kijken