Team:MIT/Experiments/Promoters

How does endometriosis respond to hormones?

Estrogen

There are endogenous estrogen receptors in two forms: ER-alpha and ER-beta. When a healthy cell senses estrogen, the ER-alpha receptor is activated and triggers downstream responses by binding to different sites, such as an estrogen responsive element. Diseased cells respond in the same fashion as healthy cells.

Progesterone

There are also endoegenous progesterone receptors in two forms: PR-A and PR-B. When a healthy cell senses progesterone, its PR receptors are activated and trigger downstream responses by binding to different sites, such as a progesterone responsive element. However, in a diseased cell, while progesterone is present, it does not co-activate the progesterone receptors, and in turn does not result in any downstream effects.

How does endometriosis respond to hormones?

Set Up

Write about the experimental set up here

Results

Write about the results here