Team:Tokyo Tech/Modeling Overview
Modeling Overview
OVERVIEW
To reproduce ”Snow White”, we have designed the cell-cell communication system with improved or characterized parts and collect data from exhaustive experiments. However, since our gene circuits are so complex that we couldn’t predict whether E. coli can play the story, we constructed the mathematical model and simulate them. This simulation successfully contributed to give the suggestions to wet lab experiments and confirm the feasibility of our system. Also, in order to utilize TA system, we developed the software in Java for adjusting the number of ACA sequences, which MazF dimer recognizes and cleaves in mRNAs.
MATHEMATICAL MODEL
To simulate our gene circuits, we developed an ordinary differential equation model.
RESULTS OF SIMULATION
Lastly we got and verified the desirable behavior of the fluorescence by modifying and improving them. As described below, it is consistent with the development of story.
SOFTWARE
ACA Sequence:
