UofC Calgary
Our Project
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Project Description
Each year on Earth, we receive 2.4 mSv of ionizing radiation. In space however without the protection of the magnetosphere, astronauts receive ionizing radiation in the range of 50 to 2000 mSv. This exposure to ionizing radiation in space causes the build-up of double strand breaks in DNA. This high energy radiation has the ability to create double stranded breaks in our DNA via multiple pathways. These breaks can cause significant damage to our DNA and if damage occurs in oncogenes or tumour suppressor genes then the likelihood of getting cancer increase a thousand fold. Research has shown that Bowman-Birk Inhibitor (BBI), a soybean derived protease inhibitor, has been found to possess radioprotective effects on DNA. Previous studies have shown that BBI suppresses carcinogenesis, increasing the survival rate of cells significantly when irradiated. BBI is also found to be an anti-cougulant, as a result it cannot be administered directly, however it can be truncated (mBBI) with only radio-protective domain present. We are creating a transdermal delivery system, which will host B. subtilis transformed with mBBI gene tagged with a transdermal tag. This will allow the peptide to travel through the skin layers and into the bloodstream, where it will be dispersed throughout the body. Subsequently, BBI will provide radioprotection to the whole body from the ionizing radiationō. By using B. subtilis to produce the peptide instead of traditional means of delivery, it will allow constant delivery and bypasses the sinusoidal pharmacokinetic problem. This is achieved by the bacteria that are present in our patch, as they will constantly produce mBBI. Ultimately our transdermal delivery system will allow for other peptides and proteins to be delivered for the use of cell based therapeutics in space.
Our Project
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Radiation
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Access to Nutrients
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Resource Limitations
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Reusable Framework
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Escherichia coli
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Basillus Subtilis
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Deinococcus radiodurans
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Our Project
About us
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- Lit af project
- Sick lab
- Huge fam
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