Team:MIT

• BACKGROUND
• EXPERIMENTS
  Synthetic Promoters microRNA Recombinase Proof of Concept Collaborations
• FUTURE WORK
  Circuit Design Clinical Applications
• HUMAN PRACTICES
  Parts Toolbox Accessible Protocols Integrated Human Practices Public Outreach Interlab Study
• NOTEBOOK
  Lab Notebook Parts Mammalian Parts Collection Attributions Safety
• AWARDS
  HP Silver HP Gold Integrated HP Basic Part
• TEAM

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  Read more about endometriosis
  
  

This diagnostic process can be expedited by using the following synthetic biological tools to sense molecular markers in endometrial biopsy samples.

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  Respond to malfunctioning of hormone sensing in endometriosis
  
  
  
  
  
  Read more
  
  
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  Identify cells in disease state through dysregulated miRNA activity
  
  
  
  
  
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  Give the circuit a form of memory through a biological latch system
  
  
  
  
  
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  Explore how our sensors interact logically by transfecting 4 to 5-unit genetic circuits into model cell cultures
  
  
  
  
  
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We've successfully created new, hormone-inducible mammalian promoters,
characterized miRNA sensors in a model cell line under varying estrogen conditions,
and tested the functionality of a serine integrase (TP901) in a mammalian line.

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  Read more about the future of our work through circuit design, clinical application, and iGEM collaborations
  
  

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