Team:BGIC China

Ellz's Site Copy

  • Project description
  • Proof of concept
  • Parts
  • Human practice
  • Attributions
  • Collaborations

    • Paper, but more than a paper

      Programmable and open-source Next Generation Bio-Chip (NGBC) based on cell-free system

      READ MORE ↓

    • Programmable

      Give bio-chip different functions by re-construct immobilized genetic circuits.

      Cell-Free

      Bio-safety, low noise and more possibilities.

      Open-Source

      Distribute technology around the world.

      Short Prototyping Time

      Build a new bio-chip just with in a week.

      One-Step & High-Throughput

      Complete all the reactions on one bio-chip and test for multiple samples together.

      Ultra-High Expression

      U-HEC (Utra-High Expression Cassette) enables high protein expression on the bio-chip.

      Unlimited Potentials

      It is possible to testing for everything by construct proper genetic circuits.

    • Project Abstract

      NGBC --- Next Generation Bio-Chip, is what we are going to create. This will be the first bio-chip ever that allows user with knowledge in synthetic biology to easily re-program and re-construct it in order to make new bio-chips with different functions.

      NGBC use genetic circuits to process the input signals and given output results. In order to minimize the disruptions and limitations of biochemical reactions inside a living-cell, the reaction center of NGBC will use S30 cell-free system which is produced from cell extracts and could provide all the conditions required for biochemical reactions like that inside a real living-cell. What is most amazing is that the complete genetic circuits and cell-free system is just carried by simple filter paper and no other expensive materials required to construct it. We are also developing a hardware and a software which can be integrated with NGBC to provide a more accurate data readout and a more interactive user environment.

      In future, we intended to develop a completely open-source NGBC kit which contains all the necessary materials, protocols and genetic components required to re-program the BioChip, and the kit will be distributed to labs around the world so there will be more new BioChips with different functions be developed. We will also create an NGBC clinical database that includes all the verified BioChips which are able to measure the concentration of target clinical molecules such as glucose, nitrate and fatty-acids in the clinical sample with in a certain range.