Team:UiOslo Norway
Urinetrouble
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The 2016 Oslo team
We are the 2016 iGEM team from the University of Oslo, found in Oslo, the heart of Norway. We are a total of seven students with different areas of expertise; informatics, pharmacy, nanotechnology and molecular biology. We have two main supervisors, Dirk Linke and Eric de Muinck. If you want to get to know us better, press the TEAM button.
Our project, URINETROUBLE, is about detecting Extended Spectrum β-lactamase (ESBL) producing bacteria in urinary tract infections. ESBL producing bacteria are antibiotic resistant bacteria which produce an enzyme called β-lactamase. β-lactamase cleaves the β-lactamring, a structure found in many of our most common antibiotics, thereby making these antibiotics ineffective. Effective detection of these bacteria would enable medical personnel to more accurately prescribe the right antibiotics the first time a patient comes in with an infection.
Antibiotic resistance
We pick up the mantle in the battle towards antibiotic resistance, one of the biggest threats to the world as we know it. The World Health Organizaion (WHO) has listed antibiotic resistance as one of the most severe threats to global health. This affects all of us, independent of age and country. The consequences of antibiotic resistance are that smaller operations and common infections that today are treatable, such as pneumonia and urinary tract infections, can become deadly.
By improving diagnostics,unnecessary and wrong use of antibiotics can be prevented, enabling us to contain the spread of resistant microbes before it becomes too late for all of us.
Phonelab
We present PhoneLab, a functioning diagnostic tool for that could easily be commercialized. By combining our own unique hardware and software with traditional molecular biology and the incredible power residing in modern smartphones, we have created the chassis of a mobile, easy-to-use and cheap detection tool usable in many different biological samples. With PhoneLab, we present a product that could play a role in changing the face of modern diagnostics.
Todays detection methods are either too expensive and require expertise or take too much time and create risk waste. Therefore, a lot of patients unfortunately get a prescription for antibiotics before being tested for the presence of antibiotic resistant microbes. PhoneLab obliterates these problems, allowing such tests to be done within minutes. Thus, antibiotics can be prescribed in a justifiable and accurate way.
