Team:UNebraska-Lincoln/Integrated Practices 4
Our Safety Case
The safety case we created will ideally serve as a model for other iGEM teams and set the precedent of how safety cases can be used as a safety platform for the iGEM competition. The scope of our safety case is limited to the serA kill switch.
Identified Environmental Hazards:
- Bacterial Conjugation
- Accidental Release
- Natural Migration
- Decomposition of biomass from dead E. coli cells
- Gene products - serA
- Reliability of the BioBricks
Knockout Nitrate: Our serA Kill Switch Safety Case Diagram
Click here to view the safety case in a diagram format
Click here to view the safety case in a text format
Our safety case is not perfect. Realistically no safety case applied to biology really can be. Since the scope of the iGEM project is limited due to time constraints, experimental results that validate the safety of systems in simulated environments may be hard to come by. In software engineering, when safety arguments are not fully developed, it is common practice to indicate this in the diagram with a diamond following any claim that cannot yet be supported with current evidence.
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