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Revision as of 13:08, 18 October 2016
Network Mechanism Analysis
Contents
Overview and Motivation Methodology Results ConclusionsOverview and Motivation
During discussions with the experimental team it became clear to us that the exact reaction mechanism in place was not clearly understood. By modelling a range of different potential mechanisms and comparing the outputs to experimental data we could draw conclusions about the accuracy of the mechanisms and hence refine the model in an effort to produce more accurate predictions and improve our understanding of the system.
There were a few different mechanisms tested in this analysis
| Reaction One (GOx) | Reaction Two (HRP) |
|---|---|
| Irreversible Michaelis-Menten Kinetics | Irreversible Michaelis-Menten Kinetics |
| Reversible Michaelis-Menten Kinetics | Reversible Michaelis-Menten Kinetics |
| Uni-Bi Kinetics | Bi-Uni Kinetics |
Methodology
For each of the combinations of potential rate equations for each step the following was undertaken:
The model was run with many iterations. The concentration at steady state for each iteration was recorded and plotted in a histogram. Experimental steady state data was then compared to these histograms.
Return to top of pageResults
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Return to top of pageConclusions
From the graphs you can see that...
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