Difference between revisions of "Team:Oxford/Timeline"

 
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<div id="banner" style="background-image: url(https://static.igem.org/mediawiki/2016/thumb/0/0d/Timeline.png/800px-Timeline.png);"></div>
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<div class="container">
 
<div class="container">
 
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        <h1 id="timeline">Timeline</h1>
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<div class="pageTitle pageTitleOrange">Timeline</div>
 
     </div>
 
     </div>
 
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          <div class="timeline-badge"><i class="glyphicon glyphicon-check"></i></div>
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<img src="https://static.igem.org/mediawiki/2016/a/a2/T--Oxford--teamphot.jpeg" style="float:right; width:300px; border-radius: 50%;">
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               <h4 class="timeline-title">Mussum ipsum cacilds</h4>
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               <h3 class="timeline-title">Forming a team</h3>
−
               <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i> 11 hours ago via Twitter</small></p>
+
               <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i>December 2015</small></p>
 
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               <p>Mussum ipsum cacilds, vidis litro abertis. Consetis adipiscings elitis. Pra lá , depois divoltis porris, paradis. Paisis, filhis, espiritis santis. Mé faiz elementum girarzis, nisi eros vermeio, in elementis mé pra quem é amistosis quis leo. Manduma pindureta quium dia nois paga. Sapien in monti palavris qui num significa nadis i pareci latim. Interessantiss quisso pudia ce receita de bolis, mais bolis eu num gostis.</p>
+
               <p>The iGEM team from last year organised the selection of the current team and we all met for the first time. Over the Christmas vacation we began to brainstorm potential ideas and talked to the public to identify issues that people wanted to be addressed.</p>
 
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             </div>
 
           </div>
 
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<img src="https://static.igem.org/mediawiki/2016/2/2b/T--Oxford--bacteria.png" style="float:left; width:300px; margin-top:70px;">
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             <div class="timeline-heading">
 
             <div class="timeline-heading">
−
               <h4 class="timeline-title">Mussum ipsum cacilds</h4>
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               <h3 class="timeline-title">Idea evaluation</h3>
 +
              <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i>January 2016</small></p>
 
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             </div>
 
             <div class="timeline-body">
 
             <div class="timeline-body">
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               <p>Mussum ipsum cacilds, vidis litro abertis. Consetis adipiscings elitis. Pra lá , depois divoltis porris, paradis. Paisis, filhis, espiritis santis. Mé faiz elementum girarzis, nisi eros vermeio, in elementis mé pra quem é amistosis quis leo. Manduma pindureta quium dia nois paga. Sapien in monti palavris qui num significa nadis i pareci latim. Interessantiss quisso pudia ce receita de bolis, mais bolis eu num gostis.</p>
+
               <p>We begin to investigate the feasibility of 3 potential ideas: tackling antibiotic resistance through bacterial conjugation, developing a probiotic treatment for Wilson’s Disease, and using a molecular circadian clock system for diurnal hormone release.
−
              <p>Suco de cevadiss, é um leite divinis, qui tem lupuliz, matis, aguis e fermentis. Interagi no mé, cursus quis, vehicula ac nisi. Aenean vel dui dui. Nullam leo erat, aliquet quis tempus a, posuere ut mi. Ut scelerisque neque et turpis posuere pulvinar pellentesque nibh ullamcorper. Pharetra in mattis molestie, volutpat elementum justo. Aenean ut ante turpis. Pellentesque laoreet mé vel lectus scelerisque interdum cursus velit auctor. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Etiam ac mauris lectus, non scelerisque augue. Aenean justo massa.</p>
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          <div class="timeline-badge danger"><i class="glyphicon glyphicon-credit-card"></i></div>
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<img src="https://static.igem.org/mediawiki/2016/4/49/T--Oxford--light.gif" style="float:right; width:300px; margin-right:100px;">
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             <div class="timeline-heading">
 
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−
               <h4 class="timeline-title">Mussum ipsum cacilds</h4>
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               <h3 class="timeline-title">Idea to the vote</h3>
 +
              <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i>March 2016</small></p>
 
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             <div class="timeline-body">
 
             <div class="timeline-body">
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               <p>Mussum ipsum cacilds, vidis litro abertis. Consetis adipiscings elitis. Pra lá , depois divoltis porris, paradis. Paisis, filhis, espiritis santis. Mé faiz elementum girarzis, nisi eros vermeio, in elementis mé pra quem é amistosis quis leo. Manduma pindureta quium dia nois paga. Sapien in monti palavris qui num significa nadis i pareci latim. Interessantiss quisso pudia ce receita de bolis, mais bolis eu num gostis.</p>
+
               <p>Based on public desire for novel medical treatments, we decide that our track will be therapeutics and we confirm that our final project will investigate a probiotic treatment for Wilson’s Disease.  
 +
</p>
 
             </div>
 
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<img src="https://static.igem.org/mediawiki/2016/2/23/T--Oxford--garry.jpeg" style="float:left; width:300px; margin-left:100px; border-radius: 50%;">
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             <div class="timeline-heading">
−
               <h4 class="timeline-title">Mussum ipsum cacilds</h4>
+
               <h3 class="timeline-title">Literature review</h3>
 +
              <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i>April 2016</small></p>
 
             </div>
 
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             <div class="timeline-body">
 
             <div class="timeline-body">
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               <p>Mussum ipsum cacilds, vidis litro abertis. Consetis adipiscings elitis. Pra lá , depois divoltis porris, paradis. Paisis, filhis, espiritis santis. Mé faiz elementum girarzis, nisi eros vermeio, in elementis mé pra quem é amistosis quis leo. Manduma pindureta quium dia nois paga. Sapien in monti palavris qui num significa nadis i pareci latim. Interessantiss quisso pudia ce receita de bolis, mais bolis eu num gostis.</p>
+
               <p>We meet with Dr Garry Brown, a medical lecturer with prior experience in the treatment of Wilson’s Disease. He confirms that lack of innovation with regards to the development of novel treatments has resulted in the continued use of medicines that patients are dissatisfied with. Following this, we begin an in-depth literature review to determine how we might develop a probiotic treatment based on the expression of copper-chelating proteins.  
 +
</p>
 
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<img src="https://static.igem.org/mediawiki/2016/8/87/T--Oxford--wdsg.jpeg" style="float:right; width:300px; border-radius: 50%;">
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              <h3 class="timeline-title">Insight from patients' perspective</h3>
 +
              <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i>May 2016</small></p>
 +
            </div>
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            <div class="timeline-body">
 +
              <p>We talk to Valerie Wheater, treasurer of the Wilson's Disease Support Group and Wilson's Disease patient. She highlights 3 main limitations associated with current treatments: side effects, high dosage frequency, and price. She expresses the general desire among patients for a longer term treatment. We alter our project design to address these concerns; most significantly, we decide to use copper-sensitive promoters to drive expression.
 +
</p>
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              <h3 class="timeline-title">Dry Lab & Human Practices starts</h3>
 +
              <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i>June 2016</small></p>
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            <div class="timeline-body">
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              <p>We begin modelling our system and alter certain aspects of our genetic circuitry in response to initial predictions, this includes designing feedback iterations of our initial promoters. </p><p>In addition, we begin outreach activities and host summer school events.
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<img src="https://static.igem.org/mediawiki/2016/8/8d/T--Oxford--tubes.jpg" style="float:right; width:300px; margin-right:100px;">
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              <h3 class="timeline-title">Wet Lab starts</h3>
 +
              <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i>July 2016</small></p>
 +
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            <div class="timeline-body">
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              <p>Work begins in the lab, as we start to clone our constructs.
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               <h4 class="timeline-title">Mussum ipsum cacilds</h4>
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               <h3 class="timeline-title">Sensitivity measurement of promoters</h3>
 +
              <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i>August 2016</small></p>
 
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             <div class="timeline-body">
 
             <div class="timeline-body">
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               <p>Mussum ipsum cacilds, vidis litro abertis. Consetis adipiscings elitis. Pra lá , depois divoltis porris, paradis. Paisis, filhis, espiritis santis. Mé faiz elementum girarzis, nisi eros vermeio, in elementis mé pra quem é amistosis quis leo. Manduma pindureta quium dia nois paga. Sapien in monti palavris qui num significa nadis i pareci latim. Interessantiss quisso pudia ce receita de bolis, mais bolis eu num gostis.</p>
+
               <p>We start collecting data on the sensitivity of our promoters using spectrophotometry, flow cytometry, and microscopy.  
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               <h4 class="timeline-title">Mussum ipsum cacilds</h4>
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               <h3 class="timeline-title">Test on chelators and beads</h3>
 +
              <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i>September 2016</small></p>
 
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             <div class="timeline-body">
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               <p>Mussum ipsum cacilds, vidis litro abertis. Consetis adipiscings elitis. Pra lá , depois divoltis porris, paradis. Paisis, filhis, espiritis santis. Mé faiz elementum girarzis, nisi eros vermeio, in elementis mé pra quem é amistosis quis leo. Manduma pindureta quium dia nois paga. Sapien in monti palavris qui num significa nadis i pareci latim. Interessantiss quisso pudia ce receita de bolis, mais bolis eu num gostis.</p>
+
               <p>We carry out copper assays to characterise the chelation ability of our copper-chelating proteins. We also carry out bead experimentation following discussions with patients over a possible delivery method for our bacteria.</p>
 
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               <h3 class="timeline-title">Wiki Freeze and the Giant Jamboree!</h3>
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              <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i>October 2016</small></p>
 
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               <p>Mussum ipsum cacilds, vidis litro abertis. Consetis adipiscings elitis. Pra lá , depois divoltis porris, paradis. Paisis, filhis, espiritis santis. Mé faiz elementum girarzis, nisi eros vermeio, in elementis mé pra quem é amistosis quis leo. Manduma pindureta quium dia nois paga. Sapien in monti palavris qui num significa nadis i pareci latim. Interessantiss quisso pudia ce receita de bolis, mais bolis eu num gostis.</p>
+
               <p>We finalise our project and pitch our idea.</p>
 
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Latest revision as of 16:29, 18 October 2016

iGEM Oxford 2016 - Cure for Copper

Timeline

  • Forming a team

    December 2015

    The iGEM team from last year organised the selection of the current team and we all met for the first time. Over the Christmas vacation we began to brainstorm potential ideas and talked to the public to identify issues that people wanted to be addressed.

  • Idea evaluation

    January 2016

    We begin to investigate the feasibility of 3 potential ideas: tackling antibiotic resistance through bacterial conjugation, developing a probiotic treatment for Wilson’s Disease, and using a molecular circadian clock system for diurnal hormone release.

  • Idea to the vote

    March 2016

    Based on public desire for novel medical treatments, we decide that our track will be therapeutics and we confirm that our final project will investigate a probiotic treatment for Wilson’s Disease.

  • Literature review

    April 2016

    We meet with Dr Garry Brown, a medical lecturer with prior experience in the treatment of Wilson’s Disease. He confirms that lack of innovation with regards to the development of novel treatments has resulted in the continued use of medicines that patients are dissatisfied with. Following this, we begin an in-depth literature review to determine how we might develop a probiotic treatment based on the expression of copper-chelating proteins.

  • Insight from patients' perspective

    May 2016

    We talk to Valerie Wheater, treasurer of the Wilson's Disease Support Group and Wilson's Disease patient. She highlights 3 main limitations associated with current treatments: side effects, high dosage frequency, and price. She expresses the general desire among patients for a longer term treatment. We alter our project design to address these concerns; most significantly, we decide to use copper-sensitive promoters to drive expression.

  • Dry Lab & Human Practices starts

    June 2016

    We begin modelling our system and alter certain aspects of our genetic circuitry in response to initial predictions, this includes designing feedback iterations of our initial promoters.

    In addition, we begin outreach activities and host summer school events.

  • Wet Lab starts

    July 2016

    Work begins in the lab, as we start to clone our constructs.

  • Sensitivity measurement of promoters

    August 2016

    We start collecting data on the sensitivity of our promoters using spectrophotometry, flow cytometry, and microscopy.

  • Test on chelators and beads

    September 2016

    We carry out copper assays to characterise the chelation ability of our copper-chelating proteins. We also carry out bead experimentation following discussions with patients over a possible delivery method for our bacteria.

  • Wiki Freeze and the Giant Jamboree!

    October 2016

    We finalise our project and pitch our idea.