Difference between revisions of "Team:William and Mary/Description"

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Circuit Control
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Motivation
 
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  This is the project description page.  It wil serve as the basic section block
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  Genetic circuits exist in great abundance in nature as complex metabolic pathways which interact
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  for any of our additional imformation pages - those aside from the project overview flowing
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  in various ways to perform vital cellular processes. Synthetic biologists aim to not only understand
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  presentation page. The flowing format is automatically created - only the text in the html
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  naturally occurring circuit networks, but also to modify them or to conceptualize and build entirely
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  needs to be edited.  This block of text here can be used as a basic 'abstract' for this page.
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  new circuits.  
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  The text-color used in this block is specified inline for ease of access.
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Hello, this is the description. This is just a test to see what this text would look like center-
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The inherent versatility of synthetic genetic circuitry has lead to a vast array of diverse applications
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column.  It looks pretty nice, so I think I'm going to keep it like this for now. To keep aligned
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in countless fields. However, the field remains fundamentally limited by the magnitude and specificity of
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with the header, I have inserted a left-side padding of 70px. This was a rough estimate and can be
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behavioral control over genetic circuits and circuit networks. These limitations can be boiled down to two
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changed. Here we can describe our project in more detail than on the front page. Right now, I'm
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essential problems: inherent constraints to behavior based on the nature of a circuit’s constituent genes,
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just populating the page with text.
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and the inefficiency of the “design-build-test” cycle which is relied upon for the construction of effective
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circuit models.
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The fundamental constraints of integral circuit components limit the ability to design and construct
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genetic circuits of arbitrary and highly specific behavior. When constructing a circuit with some intended
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behavior, design is limited by the available input-specific regulators to gene expression and their
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characteristic regulatory behavior. In order to achieve more precise behavioral control, the ability to
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tune expression levels of regulatory elements to some desired level is vital. This limitation highlights
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the need for genetic devices that can modify the behavior of arbitrary genetic circuits; implementing these
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devices would enable precise behavioral control invariant to the constraints of the constituent genes that
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make up the circuit in question [1].
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Revision as of 09:36, 19 October 2016


...

Description

Motivation

Genetic circuits exist in great abundance in nature as complex metabolic pathways which interact in various ways to perform vital cellular processes. Synthetic biologists aim to not only understand naturally occurring circuit networks, but also to modify them or to conceptualize and build entirely new circuits.

The inherent versatility of synthetic genetic circuitry has lead to a vast array of diverse applications in countless fields. However, the field remains fundamentally limited by the magnitude and specificity of behavioral control over genetic circuits and circuit networks. These limitations can be boiled down to two essential problems: inherent constraints to behavior based on the nature of a circuit’s constituent genes, and the inefficiency of the “design-build-test” cycle which is relied upon for the construction of effective circuit models.

The fundamental constraints of integral circuit components limit the ability to design and construct genetic circuits of arbitrary and highly specific behavior. When constructing a circuit with some intended behavior, design is limited by the available input-specific regulators to gene expression and their characteristic regulatory behavior. In order to achieve more precise behavioral control, the ability to tune expression levels of regulatory elements to some desired level is vital. This limitation highlights the need for genetic devices that can modify the behavior of arbitrary genetic circuits; implementing these devices would enable precise behavioral control invariant to the constraints of the constituent genes that make up the circuit in question [1].