Difference between revisions of "Team:Duke"

 
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{{Duke}}
 
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      <img src="https://static.igem.org/mediawiki/2016/5/52/T--Duke--Scientist1_and_.jpeg" alt="...">
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      <center><img style="margin: 0 auto"src="https://static.igem.org/mediawiki/2016/0/06/T--Duke--TeamPic.jpeg" alt="Team" width="900" height="850"></center>
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      <h2>AFFORDABLE, SAFER CANCER MEDS</h2>
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      <h2>Hello! We’re the Duke iGEM!</h2>
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      <p>WE INCREASE TAXOL SAFETY AND PRODUCTION DRAMATICALLY <br /> BY USING CONTROLLED BACTERIAL PRODUCERS</p>
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      <p>We are group of undergrads that came together because we are really passionate about synthetic biology. We spent our summer working on synthesizing Taxol. We learned a lot about bioengineering and had fun doing it.</p>
 
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      <center><img src="https://static.igem.org/mediawiki/2016/8/87/T--Duke--Yew_Berries.jpg" alt="Yew Berries" width="1050" height="850"></center>
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      <h2>PREVENT TAXOL SOURCE PLANT EXTINCTION</h2>
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      <p>TAXOL PLANT IS OVERHARVESTED <br /> DUKE IGEM's ENGINEERED BACTERIA WILL TAKE OVER ALL PRODUCTIOn</p>
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      <h2>CANCER MEDICINE PLANT IN SHORT SUPPLY</h2>
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      <p>The main Taxol plant (Taxus Bervifolia) is few in number <br /> Duke iGEM engineers and grows bacteria through humane methods to provide infinite supplies of taxol to treat cancer</p>
 
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      <h2>HERE IS BREAKING BAD HAPPENING</h2>
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      <p> IT'S A REALLY GOOD SHOW!<br/></p>
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<section class="bg-primary" id="about" style="background-image: url(https://static.igem.org/mediawiki/2016/c/c3/T--Duke--Canada_and_.jpeg); background-size: cover; background-position: center">
 
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                     <h1 class="section-heading"> <u>How to Produce Lots of <br/>Cancer Drugs Sustainably?</u></h1>
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                     <h1 class="section-heading" style="font-family: Indie Flower; font-weight:bolder; font-size: 55px">How to Produce Lots of <br/>Cancer Drugs Sustainably?</h1>
 
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<h2 style="color:#337ab7; font-family: Muli"><span class="glyphicon glyphicon-question-sign" aria-hidden="true"></span> Identifying Cancer Drug in Short Supply</h2>
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<h2 style="color:#337ab7; font-family: Muli; font-size: 3em"><span class="glyphicon glyphicon-question-sign" aria-hidden="true"></span> Identifying Cancer Drug in Short Supply</h2>
 
<p>Our case is taxol, a famous chemotherapy drug that derives its chemistry from Pacific Yew Tree barks.</p>
 
<p>Our case is taxol, a famous chemotherapy drug that derives its chemistry from Pacific Yew Tree barks.</p>
 
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<h6>PDB Citation: Bank, RCSB Protein Data. "TAXOL." RCSB PDB. N.p., n.d. Web. 27 Sept. 2016.</h6>
 
<h6>PDB Citation: Bank, RCSB Protein Data. "TAXOL." RCSB PDB. N.p., n.d. Web. 27 Sept. 2016.</h6>
 
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      <p style="font-family: Raleway; font-size:20px">The lack of chemotherapy drugs risks patients' lives. Taxol is a famous and effective cancer drug whose production rests on the steady supply of Pacific Yew Trees. However, as more people develop cancer, Pacific Yew Trees are being overharvested and endangered.</p>
 
      <p style="font-family: Raleway; font-size:20px">The lack of chemotherapy drugs risks patients' lives. Taxol is a famous and effective cancer drug whose production rests on the steady supply of Pacific Yew Trees. However, as more people develop cancer, Pacific Yew Trees are being overharvested and endangered.</p>
 
  <p style="font-family: Raleway; font-size:20px">In the forseeable future, there will be fewer Yew Trees. Taxol will become less affordable for patients. Worse, when Yew Trees become extinct, Taxol will lose its most essential ingredient. What can we do?</p>
 
  <p style="font-family: Raleway; font-size:20px">In the forseeable future, there will be fewer Yew Trees. Taxol will become less affordable for patients. Worse, when Yew Trees become extinct, Taxol will lose its most essential ingredient. What can we do?</p>
  
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      <p style="font-family: Raleway; font-size:20px">After an analysis of Yew Trees' genetic structure relevant to taxol production, we identified eight genetic processes. And these genes are transferrable!</p>
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      <p style="font-family: Raleway; font-size:20px">After an analysis of Yew Trees' genetic structure relevant to taxol production, we identified eight transferrable essential genetic sequences for producing taxol ingredients.</p>
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  <p style="font-family: Raleway; font-size:20px">Therefore, it's possible to teach someone else to produce Yew Trees' stuff. The next important step is to find the perfect replacement producer to relieve Yew Trees of their noble duty.</p>
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  <p style="font-family: Raleway; font-size:20px">Therefore, it's possible to reinvent taxol production. The next important step is to find the perfect replacement producer to relieve the Yew Trees of their noble duty.</p>
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<h2 style="color:#337ab7;font-family: Muli" ><span class="glyphicon glyphicon-search" aria-hidden="true"></span> Rethink the Production Process</h2>
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<h2 style="color:#337ab7;font-family: Muli; font-size:3em" ><span class="glyphicon glyphicon-search" aria-hidden="true"></span> Rethink the Production Process</h2>
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<p>Why don't we get a new producer for this essential taxol ingredient? Our solution will dramatically increase taxol production, create Pacific Yew Trees a permanent break from overharvest and danger of extinction. </p>
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<p>New producer will dramatically increase taxol production, allow Pacific Yew Trees a permanent break from overharvest and danger of extinction. </p>
 
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<h2 style="color:#337ab7;font-family: Muli"><span class="glyphicon glyphicon-sunglasses" aria-hidden="true"></span> Bacteria!</h2>
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<h2 style="color:#337ab7;font-family: Muli;font-size:3em"><i class="fa fa-check-square-o" aria-hidden="true"></i></span> Bacteria!</h2>
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<p>Bacterial Production in a controlled lab is safer and sustainable, with a dramatically larger yield!</p>
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<p>Bacterial Production in a controlled lab is safe and sustainable, with a dramatically larger yield!</p>
 
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      <p style="font-family: Raleway; font-size:20px">At Duke iGEM, we have already begun the process of sequentially arranging these genes and growing bacteria with their new powers. </p>
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      <p style="font-family: Raleway; font-size:20px">At Duke iGEM, we have already begun the process of sequentially arranging these genes and growing bacteria with these new powers. </p>
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  <p style="font-family: Raleway; font-size:20px">Therefore, it's possible to teach someone else to produce Yew Trees' stuff. The next important step is to find the perfect replacement producer to relieve Yew Trees of their noble duty.</p>
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  <p style="font-family: Raleway; font-size:20px">We believe our idea is implementable and has a revolutionary positive impact on future treatments of cancer, saving more lives at a lower cost.</p>
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  <img src="https://static.igem.org/mediawiki/2016/b/bf/T--Duke--bacteria_and_.jpeg" style="display:block; margin-left:auto;margin-right:auto" width="60%">
 
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Latest revision as of 20:26, 19 October 2016

How to Produce Lots of
Cancer Drugs Sustainably?

Presented by Duke iGEM

Identifying Cancer Drug in Short Supply

Our case is taxol, a famous chemotherapy drug that derives its chemistry from Pacific Yew Tree barks.

Error: Embedded data could not be displayed.

Annotated Taxol 2D Structure (3D Structure in Project Page)

PDB Citation: Bank, RCSB Protein Data. "TAXOL." RCSB PDB. N.p., n.d. Web. 27 Sept. 2016.

The lack of chemotherapy drugs risks patients' lives. Taxol is a famous and effective cancer drug whose production rests on the steady supply of Pacific Yew Trees. However, as more people develop cancer, Pacific Yew Trees are being overharvested and endangered.

In the forseeable future, there will be fewer Yew Trees. Taxol will become less affordable for patients. Worse, when Yew Trees become extinct, Taxol will lose its most essential ingredient. What can we do?

After an analysis of Yew Trees' genetic structure relevant to taxol production, we identified eight transferrable essential genetic sequences for producing taxol ingredients.

Therefore, it's possible to reinvent taxol production. The next important step is to find the perfect replacement producer to relieve the Yew Trees of their noble duty.

Rethink the Production Process

New producer will dramatically increase taxol production, allow Pacific Yew Trees a permanent break from overharvest and danger of extinction.

Bacteria!

Bacterial Production in a controlled lab is safe and sustainable, with a dramatically larger yield!

At Duke iGEM, we have already begun the process of sequentially arranging these genes and growing bacteria with these new powers.

We believe our idea is implementable and has a revolutionary positive impact on future treatments of cancer, saving more lives at a lower cost.

@ 2016 Duke University iGEM