Difference between revisions of "Team:Ain Shams-Egypt"

 
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<img src="http://placehold.it/800x300/d3d3d3/f2f2f2">
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<title>WATTS-APTAMER - UP_PRETORIA iGEM</title>
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<meta content='width=device-width, initial-scale=1.0, maximum-scale=1.0, user-scalable=0' name='viewport' />
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<h2> Welcome to iGEM 2016! </h2>
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<h2> Project description </h2>
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<div class="content">
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<p>Liver cancer in adult men is the fifth most frequently diagnosed cancer worldwide, and is the second leading cause of cancer-related death in the world. In adult women, it is the seventh most commonly diagnosed cancer and the sixth leading cause of cancer death. The burden has been increasing in Egypt with a doubling in incidence rates in the last 10 years, Egypt has a one of the highest incidence of in hepatocellular carcinoma (HCC) in the world.
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<p style="text-align:center;">
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Treatment options for HCC are limited and often inefficient. Anti-cancer therapy faces major challenges, particularly in terms of specificity of treatment. The ideal therapy would eradicate tumor cells selectively with minimum side effects on normal tissue.
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<IMG SRC="https://static.igem.org/mediawiki/2016/e/e6/Ain_Shams-Egypt--Logo.png" width="50%">
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So as a team that believes in synthetic biology we searched how could we help our community regarding this problem & we found that it’s been shown that circular RNA (circ.RNA) is associated with human cancers, & some studies have been reported in HCC. Circular RNA will be delivered as it is a new area of research with around 130 circular RNA sequence detected in HCC only less than 10% of these has been investigated and characterized through previous studies.
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</p>
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Circular RNA is a type of RNA which, that forms a covalently closed continuous loop. This feature confers numerous properties to circular RNAs, many of which have only recently been identified. Circular RNAs have recently shown potential as gene regulators. Like many other alternative noncoding isoforms, the biological function of most circular RNAs are unclear, circular RNAs do not have 5' or 3' ends so they are resistant to exonuclease-mediated degradation and more stable than most linear RNAs in cells.
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<h5 style="position:relative;top:-4em;">Targeting Circular RNA Deregulation In Hepatocellular carcinoma  </h5>
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We are using mammalian cells to see the expression of the circular RNA in the deregulated micro RNA environment of the cancer cells in tissue cultures, prove their role and detect if they can serve as a biomarker in HCC, Detect the relation between its expression levels and rate of progression and the possibility of using it as a potential novel target for the treatment of HCC.
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<video class="bgvid" preload="auto" loop="loop" autoplay="false" muted="muted" volume="0"><source src="https://static.igem.org/mediawiki/2016/e/e0/PretoriaUP_Okra_Seedling_Time_Lapse.webm" type="video/webm" responsive-src="https://2015.igem.org/Team:William_and_Mary/rubik_responsive.jpg"><source src="https://static.igem.org/mediawiki/2016/1/19/PretoriaUP_Okra_Seedling_Time_Lapse.mp4" type="video/mp4">Video not supported</video>
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<a href="" data-scroll="true" data-id="#projectdesc" class="scroll-arrow hidden-xs hidden-sm">
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<h5> Styling your wiki </h5>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<div class="section section-we-are-2" id="projectdesc">
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<A NAME="whatis">
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<h5> Wiki template information </h5>
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<div class="title">
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<p class="h2WM" style="text-align:left !important;">Project Abstract</p>
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<p>Liver cancer in adult men is the fifth most frequently diagnosed cancer worldwide, and is the second leading cause of cancer-related death in the world. In adult women, it is the seventh most commonly diagnosed cancer and the sixth leading cause of cancer death.
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<h5> Editing your wiki </h5>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>  
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<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&action=edit"> Click here to edit this page! </a></p>
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<h5>Tips</h5>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<ul>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2016.igem.org/Calendar">iGEM 2016 calendar</a> </li>
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<li>Have lots of fun! </li>
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<h5>Inspiration</h5>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<ul>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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<h5> Uploading pictures and files </h5>
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<p> You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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UPLOAD FILES
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</p>
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<p><a href="https://2016.igem.org/Team:Ain_Shams-Egypt/Description">Read more on our Project Description page.</a>
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<br>
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<div class="col-md-6" align="right">
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<iframe width="853" height="450" src="https://www.youtube.com/embed/XKhTCPYY4_I" frameborder="0" allowfullscreen></iframe>
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<div class="parallax full-image pattern-image">
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<img alt="..." class="parallax-img" src="https://static.igem.org/mediawiki/2016/a/ab/AinShams-Egypt-CDNA.jpeg">
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</div><!--section section-we-are-2-->
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<p class="h2WM">Team</p>
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<a href="https://2016.igem.org/Team:Ain_Shams-Egypt/Team"><p style="text-align: center">Click here to learn more about our team.</p></a>
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</div><br><br><br><br><br>
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<div class="gradient-image" style="padding-top:55px">
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<img alt="..." src="https://static.igem.org/mediawiki/2016/e/e0/Ain_Shams-Egypt--Team1.jpg" width="100%">
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</div><!-- End Section "Team" example 1: Description & Full Image -->
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<!-- Section Sponsors -->
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<p>We would like to extend special thanks to the following organizations for their support:</p>
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<a href="https://www.zewailcity.edu.eg/"><IMG SRC="https://static.igem.org/mediawiki/2016/c/ca/Ain_Shams-Egypt--zc.jpg" height=100px style="max-width:100%"></a>
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<a href="http://eu.idtdna.com/site"><IMG SRC="https://static.igem.org/mediawiki/2016/5/5e/IDT-Logo_pasteur.jpg" height=100px style="max-width:100%"></a>
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<a href=""><IMG SRC="" height=100px style="max-width:100%"></a>
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</div><!-- End Section Sponsors -->
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</div><!--wrapper-->
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Latest revision as of 03:57, 20 October 2016

WATTS-APTAMER - UP_PRETORIA iGEM

WATTS-APTAMER - UP_PRETORIA iGEM

Targeting Circular RNA Deregulation In Hepatocellular carcinoma