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                  <td style="border:none; padding: 0 20px 0 20px;"> <a href="https://2016.igem.org/Team:Duesseldorf"><img src="https://static.igem.org/mediawiki/2016/f/f3/T--Duesseldorf--logo-white.svg"></a></td>
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                    <ul>
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                        <li><a style="color: white;" href="https://2016.igem.org/Team:Duesseldorf">Home</a></li>
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                          <a href="#">Project</a>
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                              <ul>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Description">Description</a></li>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Proof">Results</a></li>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Demonstrate">Demonstrate</a></li>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Future_Applications">Future Applications</a></li>
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                              </ul>
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                          </div>
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                        </li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">Collaborations</a></li>
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                        <li class="dropdown">
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                          <a href="#">Outreach</a>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach">Outreach</a></li>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Education</a></li>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#IHP">Integrated Practices</a></li>
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                              </ul>
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                          </div>
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                        </li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Hardware">Hardware</a></li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Attributions">Attributions</a></li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Safety">Safety</a></li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Team">Team</a></li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Parts">Parts</a></li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Experiments">Experiments</a></li>
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                    </ul>
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                    <a href="mailto:igem@hhu.de><?xml version="1.0" ?><!DOCTYPE svg  PUBLIC '-//W3C//DTD SVG 1.1//EN'  'http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd'><svg  id="Layer_1" version="1.1" viewBox="0 0 512 512"  class="social"  style="width:10%; margin-top:10px;enable-background:new 0 0 76 76;" xml:space="preserve" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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                    <br>
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                    Heinrich-Heine University <br />
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                    Universitätsstraße 1 <br />
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                    40225 Düsseldorf <br />
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                    Design by Marvin van Aalst <br>
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                  </td>
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              </tr>
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            </table>
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        </div>
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        <div class="page">
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            <div class="paper">
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              <div id="Navigation" class="navigation">
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                  <ul class="topnav">
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                    <li><a style="color: black;" href="https://2016.igem.org/Team:Duesseldorf">Home</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Description">Description</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Proof">Results</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Demonstrate">Demonstrate</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Future_Applications">Future Applications</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">Collaborations</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach">Outreach</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Education</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#IHP">Integrated Practices</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Hardware">Hardware</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Attributions">Attributions</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Safety">Safety</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Team">Team</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Parts">Parts</a></li>
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                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Experiments">Experiments</a></li>
 +
                  </ul>
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              </div>
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<img class="medal" src="https://static.igem.org/mediawiki/2016/0/0d/T--duesseldorf--medalgold-achieved.png">
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<!-------------------------- ARTICLE ---------------------------->
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      <div class="article">
  
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<div class="column full_size" >
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<video id="Logo" src="https://static.igem.org/mediawiki/2016/b/b7/T--Duesseldorf--Logo-Animation.mov" autoplay="autoplay" width="100%;" height="auto;"></video>
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<img src="https://static.igem.org/mediawiki/2016/9/9d/Optoptosis_logo_800x300_px.png">
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  <h2>Imagine you turn the switch on and the cancer is gone…</h2>
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</div>
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<p>
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Cancer is the second most common cause of death killing about 8.2 million people annually, which equals the total population of New York City.
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The global increase of cancer cases and the <a href="https://2016.igem.org/Team:Duesseldorf/Therapies">lack of highly specific therapies </a>for various types of cancer states a clear message:<br>
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New approaches have to be found, which allow a level of precision in cancer treatment that has been long-awaited.
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<p>
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Our approach aims at achieving high spatiotemporal control of <a href="https://2016.igem.org/Team:Duesseldorf/Apoptosis">apoptosis</a> in tumor cells by applying an optogenetic double-killswitch. This <a href="https://2016.igem.org/Team:Duesseldorf/Description">system</a> combines clean removal of cancer cells through apoptosis with the accuracy of light-controlled optogenetics. We utilize two optogenetic proteins, to create the desperately needed holy grail of cancer therapy.<br>
 +
This is the goal of OPTOPTOSIS.
 +
  </p>
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<h2 id="Medal_Criteria"><a href="https://2016.igem.org/Team:Duesseldorf/Medal_Criteria">Our Achievements</a></h2>
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<div class="w3-container" style="margin-bottom:50px;margin-top: 20px;">
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  <div class="w3-row">
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    <a href="javascript:void(0)" onclick="openrequirement(event, 'Bronze');">
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      <span class="w3-quarter tablink w3-bottombar w3-hover-light-grey w3-padding" style="text-align:center;"><img src="https://static.igem.org/mediawiki/2016/thumb/b/b5/T--duesseldorf--medal-bronze1.png/210px-T--duesseldorf--medal-bronze1.png" style="width: 50%; margin:auto;"></span>
 +
    </a>
 +
    <a href="javascript:void(0)" onclick="openrequirement(event, 'Silver');">
 +
      <span class="w3-quarter tablink w3-bottombar w3-hover-light-grey w3-padding" style="text-align:center;"><img src="https://static.igem.org/mediawiki/2016/thumb/a/ac/T--duesseldorf--medal-silber1.png/210px-T--duesseldorf--medal-silber1.png" style="width: 50%; margin:auto;"></span>
 +
    </a>
 +
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 +
      <span class="w3-quarter tablink w3-bottombar w3-hover-light-grey w3-padding" style="text-align:center;"><img src="https://static.igem.org/mediawiki/2016/thumb/8/8a/T--duesseldorf--medal-gold1.png/210px-T--duesseldorf--medal-gold1.png" style="width: 50%; margin:auto;"></span>
 +
    </a>
 +
    <a href="javascript:void(0)" onclick="openrequirement(event, 'Special');">
 +
      <span class="w3-quarter tablink w3-bottombar w3-hover-light-grey w3-padding" style="text-align:center;"><img src="https://static.igem.org/mediawiki/2016/thumb/1/18/T--duesseldorf--medal-special1.png/210px-T--duesseldorf--medal-special1.png" style="width: 50%; margin:auto;"></span>
 +
    </a>
 +
  </div>
  
−
<div class="column full_size" >
 
−
<h2> Welcome to iGEM 2016! </h2>
 
−
<p>Your team has been approved and you are ready to start the iGEM season! </p>
 
  
−
</div>
 
  
−
<div class="column half_size" >
+
  <div id="Bronze" class="w3-container requirement" style="padding-top: 10px;">
−
<h5>Before you start: </h5>
+
    <h2>Bronze</h2>
−
<p> Please read the following pages:</p>
+
  <h4>Register And Attend</h4>
 
<ul>
 
<ul>
−
<li> <a href="https://2016.igem.org/Requirements">Requirements page </a> </li>
+
<li>Our team was successfully registered and had the greatest summer ever</li>
−
<li> <a href="https://2016.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
+
</ul>
−
<li> <a href="https://2016.igem.org/Resources/Template_Documentation"> Template Documentation </a></li>
+
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Attributions">Attribution</a></h4>
 +
<ul>
 +
<li>We created our own Wiki with clear <a href="https://2016.igem.org/Team:Duesseldorf/Attributions">attribution</a> of each aspect of our project</li>
 
</ul>
 
</ul>
−
</div>
 
  
−
<div class="column half_size" >
+
<h4>Deliverables </h4>
−
<div class="highlight">
+
−
<h5> Styling your wiki </h5>
+
−
<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
+
−
<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
+
−
</div>
+
−
</div>
+
  
−
<div class="column full_size" >
+
<ul>
−
<h5> Wiki template information </h5>
+
<li>The judging form and <a href="https://2016.igem.org/Team:Duesseldorf/Safety">safety form</a> was completed with great care</li>
−
<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2016.igem.org/Judging/Pages_for_Awards/Instructions">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
+
<li>We are very excited to present our poster and project talk at the Giant Jamboree</li>
 +
<li>We attributed and acknowledged all of the work done for our project on our Wiki page</li>
 +
<li>We documented and created Part pages for our Parts and submitted the DNA samples of our new Parts to the Registry</li>
 +
</ul>
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Parts">Part/Contribution</a></h4>
 +
<ul>
 +
<li>We are proud of our new standard Biobrick Part and submitted <a href="https://2016.igem.org/Team:Duesseldorf/Parts">BBa_K1936000</a> to the iGEM Registry</li>
 +
</ul>
  
−
</div>  
+
  </div>
  
 +
  <div id="Silver" class="w3-container requirement" style="padding-top: 10px;">
 +
<h2>Silver</h2>   
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">Collaboration </a></h4>
 +
<ul>
 +
<li>We had great <a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">collaborations</a> with other teams and are really happy about our common success  </li>
 +
</ul>
  
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Parts">Validated Part / Validated Contribution</a></h4>
 +
<ul>
 +
<li>We characterized <a href="https://2016.igem.org/Team:Duesseldorf/Parts">BBa_K1936001</a> </li>
 +
<li>This part was submitted to the iGEM registry and is experimentally validated</li>
 +
</ul>
  
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Human Practices</a></h4>
 +
<ul>
 +
<li>Of course, we shared our project and knowledge with the public and talked about the <a href="https://2016.igem.org/Team:Duesseldorf/Ethik">ethical aspects</a>. We had a lot of fun at our different human practice activities.</li>
 +
</ul>
  
−
<div class="column half_size" >
+
  </div>
−
<h5> Editing your wiki </h5>
+
−
<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
+
−
<p> <a href="https://2016.igem.org/wiki/index.php?title=Team:Example&action=edit"> Click here to edit this page! </a></p>
+
  
−
</div>
+
  <div id="Gold" class="w3-container requirement" style="padding-top: 10px;">
 +
    <h2>Gold</h2>
  
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#IHP">Integrated Human Practices</a></h4>
 +
<ul>
 +
<li>Additionally to our <a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Human Practice</a> work we visited the <a href="https://2016.igem.org/Team:Duesseldorf/Outreach#BfArM">BfArM (the german equivalent of the FDA) and telephoned with the Paul Ehrlich Institute</a>, which is responsible for admission of genetherapeutics, to consult professional critics concerning future applications of our project </li>
 +
</ul>
  
−
<div class="column half_size" >
+
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Proof">Proof of concept</a></h4>
−
<h5>Tips</h5>
+
−
<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
+
 
<ul>
 
<ul>
−
<li>State your accomplishments! Tell people what you have achieved from the start. </li>
+
<li>We are really happy that we are able to show a functional proof of concept of our project with one of our newly created BioBricks</li>
−
<li>Be clear about what you are doing and how you plan to do this.</li>
+
</ul>
−
<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
+
−
<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
+
−
<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
+
−
<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2016.igem.org/Calendar">iGEM 2016 calendar</a> </li>
+
−
<li>Have lots of fun! </li>
+
−
</ul>
+
−
</div>
+
  
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Demonstrate">Demonstrate your work</a></h4>
 +
<ul>
 +
<li>We were able to show our functional proof of concept under real world conditions with experiments in human cancer cell culture </li>
 +
</ul>
  
−
<div class="column half_size" >
+
  </div>
−
<h5>Inspiration</h5>
+
    <div id="Special" class="w3-container requirement" style="padding-top: 10px;">
−
<p> You can also view other team wikis for inspiration! Here are some examples:</p>
+
    <h2>Special</h2>
 +
<h4>Special Prices</h4>
 +
<p>
 +
We have done some really good work so we applied for these Special Prices:
 +
</p>
 
<ul>
 
<ul>
−
<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
+
<li><a href="https://2016.igem.org/Team:Duesseldorf/Best_Part">Best New Basic Part</a></li>
−
<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
+
<li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#IHP">Best Integrated Human Practice</a></li>
−
<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
+
<li><a href="https://2016.igem.org/Team:Duesseldorf/Hardware">Best Hardware Project</a></li>
−
<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
+
<li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Best Education and Public Engagement</a></li>
−
<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
+
−
<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
+
 
</ul>
 
</ul>
−
</div>
 
  
−
<div class="column half_size" >
+
  </div>
−
<h5> Uploading pictures and files </h5>
+
 
−
<p> You can upload your pictures and files to the iGEM 2016 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
+
 
−
When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
+
</div>
  
 +
<div style="border:5px solid #0C9476;border-radius:25px;padding:10px;">
  
−
<div class="button_click" onClick=" parent.location= 'https://2016.igem.org/Special:Upload '">
+
<h2><a href="https://2016.igem.org/Team:Duesseldorf/Proof">Results</a> and engineered constructs of OPTOPTOSIS</h2>
−
UPLOAD FILES
+
<p>
 +
<img src="https://static.igem.org/mediawiki/2016/2/21/T--duesseldorf--check3.png" width="30px">Our <a href="https://2016.igem.org/Team:Duesseldorf/Proof#">red switch</a> operates as desired
 +
</p>
 +
<ul>
 +
<li>we were able to show that our apoptosis protein is expressed</li>
 +
<li>our testing cells are still alive</li>
 +
</ul>
 +
<p>
 +
<img src="https://static.igem.org/mediawiki/2016/2/21/T--duesseldorf--check3.png" width="30px">Our <a href="https://2016.igem.org/Team:Duesseldorf/Proof#">blue switch</a> operates as desired when constitutively expressed
 +
</p>
 +
<ul>
 +
<li>we were able to show that our construct is expressed</li>
 +
<li>we assume that our construct binds to the outer mitochondrial membrane but are still testing it</li>
 +
</ul>
 +
<p>
 +
<img src="https://static.igem.org/mediawiki/2016/2/21/T--duesseldorf--check3.png" width="30px">The double transfection of our <a href="https://2016.igem.org/Team:Duesseldorf/Proof#">two constructs</a> worked as desired
 +
</p>
 +
<ul>
 +
<li>we were able to detect gene expression of both constructs in transfected cells</li>
 +
<li>we were able to determine the expression of the red- switch</li>
 +
<li>we have seen indications of induced apoptosis but will further validate it
 +
</ul>
 
</div>
 
</div>
−
 
−
</div>
 
−
 
−
 
  
  
  
 +
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 +
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 +
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 +
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Latest revision as of 11:10, 4 November 2016

Home


Heinrich-Heine University
Universitätsstraße 1
40225 Düsseldorf
Design by Marvin van Aalst

Imagine you turn the switch on and the cancer is gone…

Cancer is the second most common cause of death killing about 8.2 million people annually, which equals the total population of New York City. The global increase of cancer cases and the lack of highly specific therapies for various types of cancer states a clear message:
New approaches have to be found, which allow a level of precision in cancer treatment that has been long-awaited.

Our approach aims at achieving high spatiotemporal control of apoptosis in tumor cells by applying an optogenetic double-killswitch. This system combines clean removal of cancer cells through apoptosis with the accuracy of light-controlled optogenetics. We utilize two optogenetic proteins, to create the desperately needed holy grail of cancer therapy.
This is the goal of OPTOPTOSIS.

Our Achievements

Bronze

Register And Attend

  • Our team was successfully registered and had the greatest summer ever

Attribution

  • We created our own Wiki with clear attribution of each aspect of our project

Deliverables

  • The judging form and safety form was completed with great care
  • We are very excited to present our poster and project talk at the Giant Jamboree
  • We attributed and acknowledged all of the work done for our project on our Wiki page
  • We documented and created Part pages for our Parts and submitted the DNA samples of our new Parts to the Registry

Part/Contribution

  • We are proud of our new standard Biobrick Part and submitted BBa_K1936000 to the iGEM Registry

Silver

Collaboration

  • We had great collaborations with other teams and are really happy about our common success

Validated Part / Validated Contribution

  • We characterized BBa_K1936001
  • This part was submitted to the iGEM registry and is experimentally validated

Human Practices

  • Of course, we shared our project and knowledge with the public and talked about the ethical aspects. We had a lot of fun at our different human practice activities.

Gold

Integrated Human Practices

Proof of concept

  • We are really happy that we are able to show a functional proof of concept of our project with one of our newly created BioBricks

Demonstrate your work

  • We were able to show our functional proof of concept under real world conditions with experiments in human cancer cell culture

Special

Special Prices

We have done some really good work so we applied for these Special Prices:

Results and engineered constructs of OPTOPTOSIS

Our red switch operates as desired

  • we were able to show that our apoptosis protein is expressed
  • our testing cells are still alive

Our blue switch operates as desired when constitutively expressed

  • we were able to show that our construct is expressed
  • we assume that our construct binds to the outer mitochondrial membrane but are still testing it

The double transfection of our two constructs worked as desired

  • we were able to detect gene expression of both constructs in transfected cells
  • we were able to determine the expression of the red- switch
  • we have seen indications of induced apoptosis but will further validate it