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                  <td style="border:none; padding: 0 20px 0 20px;"> <a href="https://2016.igem.org/Team:Duesseldorf"><img src="https://static.igem.org/mediawiki/2016/f/f3/T--Duesseldorf--logo-white.svg"></a></td>
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                        <li><a style="color: white;" href="https://2016.igem.org/Team:Duesseldorf">Home</a></li>
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                              <ul>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Description">Description</a></li>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Proof">Results</a></li>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Demonstrate">Demonstrate</a></li>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Future_Applications">Future Applications</a></li>
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                        </li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">Collaborations</a></li>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Education</a></li>
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                                <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#IHP">Integrated Practices</a></li>
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                              </ul>
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                          </div>
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                        </li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Hardware">Hardware</a></li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Attributions">Attributions</a></li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Safety">Safety</a></li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Team">Team</a></li>
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                        <li><a href="https://2016.igem.org/Team:Duesseldorf/Experiments">Experiments</a></li>
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                    <a href="mailto:igem@hhu.de><?xml version="1.0" ?><!DOCTYPE svg  PUBLIC '-//W3C//DTD SVG 1.1//EN'  'http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd'><svg  id="Layer_1" version="1.1" viewBox="0 0 512 512"  class="social"  style="width:10%; margin-top:10px;enable-background:new 0 0 76 76;" xml:space="preserve" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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                    <br>
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                    Heinrich-Heine University <br />
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                    Universitätsstraße 1 <br />
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                    40225 Düsseldorf <br />
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                    Design by Marvin van Aalst <br>
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              <div id="Navigation" class="navigation">
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                  <ul class="topnav">
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                    <li><a style="color: black;" href="https://2016.igem.org/Team:Duesseldorf">Home</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Description">Description</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Proof">Results</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Demonstrate">Demonstrate</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Future_Applications">Future Applications</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">Collaborations</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach">Outreach</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Education</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#IHP">Integrated Practices</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Hardware">Hardware</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Attributions">Attributions</a></li>
 +
                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Safety">Safety</a></li>
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                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Team">Team</a></li>
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                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Parts">Parts</a></li>
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                    <li><a href="https://2016.igem.org/Team:Duesseldorf/Experiments">Experiments</a></li>
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                  </ul>
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              </div>
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<img class="medal" src="https://static.igem.org/mediawiki/2016/0/0d/T--duesseldorf--medalgold-achieved.png">
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<!-------------------------- ARTICLE ---------------------------->
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      <div class="article">
  
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<video id="Logo" src="https://static.igem.org/mediawiki/2016/b/b7/T--Duesseldorf--Logo-Animation.mov" autoplay="autoplay" width="100%;" height="auto;"></video>
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  <h2>Imagine you turn the switch on and the cancer is gone…</h2>
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<p>
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<meta name="viewport" content="width=device-width, initial-scale=1.0, maximun-scale=1.0, user-scalable=no">
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Cancer is the second most common cause of death killing about 8.2 million people annually, which equals the total population of New York City.
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The global increase of cancer cases and the <a href="https://2016.igem.org/Team:Duesseldorf/Therapies">lack of highly specific therapies </a>for various types of cancer states a clear message:<br>
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New approaches have to be found, which allow a level of precision in cancer treatment that has been long-awaited.
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Our approach aims at achieving high spatiotemporal control of <a href="https://2016.igem.org/Team:Duesseldorf/Apoptosis">apoptosis</a> in tumor cells by applying an optogenetic double-killswitch. This <a href="https://2016.igem.org/Team:Duesseldorf/Description">system</a> combines clean removal of cancer cells through apoptosis with the accuracy of light-controlled optogenetics. We utilize two optogenetic proteins, to create the desperately needed holy grail of cancer therapy.<br>
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This is the goal of OPTOPTOSIS.
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<h2 id="Medal_Criteria"><a href="https://2016.igem.org/Team:Duesseldorf/Medal_Criteria">Our Achievements</a></h2>
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<li class="icon"> <a href="javascript:void(0);" style="font-size:15px;" onclick="myFunction()">☰</a> </li>
 
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<li><a href="https://2016.igem.org/Team:Duesseldorf/Contact">Contact Us!</a>
 
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<li><a href="https://2016.igem.org/Team:Duesseldorf/Parts">Parts</a>
 
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<li><a href="https://2016.igem.org/Team:Duesseldorf/Lab-Book">Lab Book</a>
 
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<li><a href="https://2016.igem.org/Team:Duesseldorf/Description">Project</a>
 
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<li><a href="https://2016.igem.org/Team:Duesseldorf/Team">Team</a>
 
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<li><a class="active" href="https://2016.igem.org/Team:Duesseldorf">Home</a>
 
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<h1>Welcome!</h1>
 
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<p>This year we established the first iGEM-team at the Heinrich Heine University in Duesseldorf in Germany. Our group consists of 22 undergraduate members, who came together to found the team in late 2015. We all joined iGEM with the motivation to apply and create synthetic biology. Already in the early stage of our project it was definite that we would emphasize on creating a mechanism to fight cancer.</p>
 
  
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<h2 style="text-align:left">The essentials of OPTOPTOSIS</h2>
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  <div id="Bronze" class="w3-container requirement" style="padding-top: 10px;">
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<p>The global increase of cancer cases and the lack of highly specific therapies for various types of cancer states a clear message: New approaches have to be found, which allow a level of precision in cancer treatment that has been long-awaited. This is the goal of OPTOPTOSIS. Our approach aims at achieving high spatiotemporal control of apoptosis in tumor cells by applying an optogenetic double-killswitch. This system combines clean removal of cancer cells through apoptosis with the precision of light-controlled optogenetics. We utilize two optogenetic proteins, namely Phytochrome B and LOV2. The red light switch based on Phytochrome B controls expression, while the blue light switch LOV2 controls localization of apoptotic proteins to their target site. <a href="https://2016.igem.org/Team:Duesseldorf/Description">Read on.</a></p>
+
    <h2>Bronze</h2>
 +
  <h4>Register And Attend</h4>
 +
<ul>
 +
<li>Our team was successfully registered and had the greatest summer ever</li>
 +
</ul>
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Attributions">Attribution</a></h4>
 +
<ul>
 +
<li>We created our own Wiki with clear <a href="https://2016.igem.org/Team:Duesseldorf/Attributions">attribution</a> of each aspect of our project</li>
 +
</ul>
  
−
<h2 style="text-align:left">Our team</h2>
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<h4>Deliverables </h4>
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<img src="https://static.igem.org/mediawiki/2016/2/22/T--Duesseldorf--Group_Photo_1.jpg" alt="Team">
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<p style="font-style:italic">Be sure to check out our marvelous photos on the <a class="active" href="https://2016.igem.org/Team:Duesseldorf/Team">team page!</a><p>
+
  
 +
<ul>
 +
<li>The judging form and <a href="https://2016.igem.org/Team:Duesseldorf/Safety">safety form</a> was completed with great care</li>
 +
<li>We are very excited to present our poster and project talk at the Giant Jamboree</li>
 +
<li>We attributed and acknowledged all of the work done for our project on our Wiki page</li>
 +
<li>We documented and created Part pages for our Parts and submitted the DNA samples of our new Parts to the Registry</li>
 +
</ul>
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Parts">Part/Contribution</a></h4>
 +
<ul>
 +
<li>We are proud of our new standard Biobrick Part and submitted <a href="https://2016.igem.org/Team:Duesseldorf/Parts">BBa_K1936000</a> to the iGEM Registry</li>
 +
</ul>
  
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<div id="Footer" class="row middle footer">
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<h3>Many thanks to our sponsors!</h3>
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<div class="col-2 col-m-4 colhalf sponsor"><img src="https://static.igem.org/mediawiki/2016/f/f5/T--Duesseldorf--Bayer_Logo.svg" alt="Bayer">
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<img src="https://static.igem.org/mediawiki/2016/5/5b/T--Duesseldorf--Biozym_Logo.jpg" alt="Biozym">
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</div>
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<div class="col-2 col-m-4 colhalf sponsor">
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<img src="https://static.igem.org/mediawiki/2016/5/5b/Muc16_Sponsor_CarlRoth.png" alt="Carl Roth">
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<div class="col-2 col-m-4 colhalf sponsor">
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<img src="https://static.igem.org/mediawiki/2016/5/55/T--Duesseldorf--Ella_Biotech_Logo.jpg" alt="Ella Biotech">
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<div class="col-2 col-m-4 colhalf sponsor">
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<img src="https://static.igem.org/mediawiki/2016/f/fa/Eppendorf-Logo.svg.png" alt="Eppendorf">
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<img src="https://static.igem.org/mediawiki/2016/e/e6/Eurofins_logo.png" alt="Eurofins">
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<img src="https://static.igem.org/mediawiki/2016/6/67/Idt_logo.png" alt="IDT">
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<img src="https://static.igem.org/mediawiki/2016/2/27/Muc16_Sponsor_NEB.png" alt="New England Biolabs">
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</div>
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<div class="col-2 col-m-4 colhalf sponsor">
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<img src="https://static.igem.org/mediawiki/2016/c/cf/2000px-Promega-Logo.svg.png" alt="Promega">
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</div>
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<div class="col-2 col-m-4 colhalf sponsor">
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<img src="https://static.igem.org/mediawiki/2016/9/9c/Qiagen_Logo.svg" alt="Qiagen">
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  <div id="Silver" class="w3-container requirement" style="padding-top: 10px;">
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<div class="col-2 col-m-4 colhalf sponsor"><img src="https://static.igem.org/mediawiki/2016/a/a1/Untitled.png" alt="Starlab">
+
<h2>Silver</h2>   
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</div>
+
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">Collaboration </a></h4>
−
<div class="col-2 col-m-4 colhalf sponsor"><img src="https://static.igem.org/mediawiki/2016/5/56/T--Duesseldorf--HHU_Logo.gif" alt="HHU">
+
<ul>
−
</div>
+
<li>We had great <a href="https://2016.igem.org/Team:Duesseldorf/Collaborations">collaborations</a> with other teams and are really happy about our common success  </li>
−
<div class="col-2 col-m-4 colhalf sponsor"><img src="https://static.igem.org/mediawiki/2016/7/7a/T--Duesseldorf--Ceplas_Logo.jpg" alt="Ceplas">
+
</ul>
−
</div>
+
 
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Parts">Validated Part / Validated Contribution</a></h4>
 +
<ul>
 +
<li>We characterized <a href="https://2016.igem.org/Team:Duesseldorf/Parts">BBa_K1936001</a> </li>
 +
<li>This part was submitted to the iGEM registry and is experimentally validated</li>
 +
</ul>
 +
 
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Human Practices</a></h4>
 +
<ul>
 +
<li>Of course, we shared our project and knowledge with the public and talked about the <a href="https://2016.igem.org/Team:Duesseldorf/Ethik">ethical aspects</a>. We had a lot of fun at our different human practice activities.</li>
 +
</ul>
 +
 
 +
  </div>
 +
 
 +
  <div id="Gold" class="w3-container requirement" style="padding-top: 10px;">
 +
    <h2>Gold</h2>
 +
 
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#IHP">Integrated Human Practices</a></h4>
 +
<ul>
 +
<li>Additionally to our <a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Human Practice</a> work we visited the <a href="https://2016.igem.org/Team:Duesseldorf/Outreach#BfArM">BfArM (the german equivalent of the FDA) and telephoned with the Paul Ehrlich Institute</a>, which is responsible for admission of genetherapeutics, to consult professional critics concerning future applications of our project </li>
 +
</ul>
 +
 
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Proof">Proof of concept</a></h4>
 +
<ul>
 +
<li>We are really happy that we are able to show a functional proof of concept of our project with one of our newly created BioBricks</li>
 +
</ul>
 +
 
 +
<h4><a href="https://2016.igem.org/Team:Duesseldorf/Demonstrate">Demonstrate your work</a></h4>
 +
<ul>
 +
<li>We were able to show our functional proof of concept under real world conditions with experiments in human cancer cell culture </li>
 +
</ul>
 +
 
 +
  </div>
 +
    <div id="Special" class="w3-container requirement" style="padding-top: 10px;">
 +
    <h2>Special</h2>
 +
<h4>Special Prices</h4>
 +
<p>
 +
We have done some really good work so we applied for these Special Prices:
 +
</p>
 +
<ul>
 +
<li><a href="https://2016.igem.org/Team:Duesseldorf/Best_Part">Best New Basic Part</a></li>
 +
<li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#IHP">Best Integrated Human Practice</a></li>
 +
<li><a href="https://2016.igem.org/Team:Duesseldorf/Hardware">Best Hardware Project</a></li>
 +
<li><a href="https://2016.igem.org/Team:Duesseldorf/Outreach#HP">Best Education and Public Engagement</a></li>
 +
</ul>
 +
 
 +
  </div>
 +
 
 +
 
 
</div>
 
</div>
 +
 +
<div style="border:5px solid #0C9476;border-radius:25px;padding:10px;">
 +
 +
<h2><a href="https://2016.igem.org/Team:Duesseldorf/Proof">Results</a> and engineered constructs of OPTOPTOSIS</h2>
 +
<p>
 +
<img src="https://static.igem.org/mediawiki/2016/2/21/T--duesseldorf--check3.png" width="30px">Our <a href="https://2016.igem.org/Team:Duesseldorf/Proof#">red switch</a> operates as desired
 +
</p>
 +
<ul>
 +
<li>we were able to show that our apoptosis protein is expressed</li>
 +
<li>our testing cells are still alive</li>
 +
</ul>
 +
<p>
 +
<img src="https://static.igem.org/mediawiki/2016/2/21/T--duesseldorf--check3.png" width="30px">Our <a href="https://2016.igem.org/Team:Duesseldorf/Proof#">blue switch</a> operates as desired when constitutively expressed
 +
</p>
 +
<ul>
 +
<li>we were able to show that our construct is expressed</li>
 +
<li>we assume that our construct binds to the outer mitochondrial membrane but are still testing it</li>
 +
</ul>
 +
<p>
 +
<img src="https://static.igem.org/mediawiki/2016/2/21/T--duesseldorf--check3.png" width="30px">The double transfection of our <a href="https://2016.igem.org/Team:Duesseldorf/Proof#">two constructs</a> worked as desired
 +
</p>
 +
<ul>
 +
<li>we were able to detect gene expression of both constructs in transfected cells</li>
 +
<li>we were able to determine the expression of the red- switch</li>
 +
<li>we have seen indications of induced apoptosis but will further validate it
 +
</ul>
 
</div>
 
</div>
  
−
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−
<p style="font-size:60%; text-align:center;">Team Optoptosis, Heinrich-Heine Universität Düsseldorf. Design by Marvin van Aalst</p>
 
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Latest revision as of 11:10, 4 November 2016

Home


Heinrich-Heine University
Universitätsstraße 1
40225 Düsseldorf
Design by Marvin van Aalst

Imagine you turn the switch on and the cancer is gone…

Cancer is the second most common cause of death killing about 8.2 million people annually, which equals the total population of New York City. The global increase of cancer cases and the lack of highly specific therapies for various types of cancer states a clear message:
New approaches have to be found, which allow a level of precision in cancer treatment that has been long-awaited.

Our approach aims at achieving high spatiotemporal control of apoptosis in tumor cells by applying an optogenetic double-killswitch. This system combines clean removal of cancer cells through apoptosis with the accuracy of light-controlled optogenetics. We utilize two optogenetic proteins, to create the desperately needed holy grail of cancer therapy.
This is the goal of OPTOPTOSIS.

Our Achievements

Bronze

Register And Attend

  • Our team was successfully registered and had the greatest summer ever

Attribution

  • We created our own Wiki with clear attribution of each aspect of our project

Deliverables

  • The judging form and safety form was completed with great care
  • We are very excited to present our poster and project talk at the Giant Jamboree
  • We attributed and acknowledged all of the work done for our project on our Wiki page
  • We documented and created Part pages for our Parts and submitted the DNA samples of our new Parts to the Registry

Part/Contribution

  • We are proud of our new standard Biobrick Part and submitted BBa_K1936000 to the iGEM Registry

Silver

Collaboration

  • We had great collaborations with other teams and are really happy about our common success

Validated Part / Validated Contribution

  • We characterized BBa_K1936001
  • This part was submitted to the iGEM registry and is experimentally validated

Human Practices

  • Of course, we shared our project and knowledge with the public and talked about the ethical aspects. We had a lot of fun at our different human practice activities.

Gold

Integrated Human Practices

Proof of concept

  • We are really happy that we are able to show a functional proof of concept of our project with one of our newly created BioBricks

Demonstrate your work

  • We were able to show our functional proof of concept under real world conditions with experiments in human cancer cell culture

Special

Special Prices

We have done some really good work so we applied for these Special Prices:

Results and engineered constructs of OPTOPTOSIS

Our red switch operates as desired

  • we were able to show that our apoptosis protein is expressed
  • our testing cells are still alive

Our blue switch operates as desired when constitutively expressed

  • we were able to show that our construct is expressed
  • we assume that our construct binds to the outer mitochondrial membrane but are still testing it

The double transfection of our two constructs worked as desired

  • we were able to detect gene expression of both constructs in transfected cells
  • we were able to determine the expression of the red- switch
  • we have seen indications of induced apoptosis but will further validate it