Difference between revisions of "Team:Oxford/Achievements"

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                <a href="#Achievements">Achievements</a>
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                <a href="#Bronze">Bronze</a>
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                <a href="#Silver">Silver</a>
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<p>Please visit <a href="https://2016.igem.org/Safety">the main Safety page</a> to find this year's safety requirements & deadlines, and to learn about safe & responsible research in iGEM.</p>
 
  
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<p>On this page of your wiki, you should write about how you are addressing any safety issues in your project. The wiki is a place where you can <strong>go beyond the questions on the safety forms</strong>, and write about whatever safety topics are most interesting in your project. (You do not need to copy your safety forms onto this wiki page.)</p>
 
  
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<div class="column full_size">
 
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<h5>Safe Project Design</h5>
 
  
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<p>Does your project include any safety features? Have you made certain decisions about the design to reduce risks? Write about them here! For example:</p>
 
  
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    <div class="col-md-9 content-right" style="background-color: #fff;">
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<div class="pageTitle pageTitleOrange">Achievements</div>
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<section id="Achievements">
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<img src="https://static.igem.org/mediawiki/2016/8/83/Happy_team_photo_Oxford_2016_Sam.jpeg" width="60%" /><figcaption>Most of the team at our banner at the Jamboree</figcaption>
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<p><center><font size="5"> Our project was awarded a <font color="#FFD700"><b>GOLD</b></font> medal at the 2016 Jamboree. <br> We were nominated for: <b>Best Therapeutic Project</b>,
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<br>
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<b>Best Wiki</b>,
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<b>Best Presentation</b> and <br>
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<b>Best Education & Public Engagement!</b></center></font></p>
 
<ul>
 
<ul>
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<li>Choosing a non-pathogenic chassis</li>
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<li> Developed an initial proof of concept for a Wilson’s Disease therapeutic as an alternative to current treatments, which have problems associated with their cost, side-effects and high dosage frequency. </li>
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<li>Choosing parts that will not harm humans / animals / plants</li>
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<li>We added 13 new BioBrick parts to the iGEM registry.
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<li>Substituting safer materials for dangerous materials in a proof-of-concept experiment</li>
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Check our <a href="https://2016.igem.org/Team:Oxford/Parts">parts page</a> for more information.</li>
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<li>Including an "induced lethality" or "kill-switch" device</li>
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<li>We investigated several different promoters and two different copper chelators with the aim of finding the most effective system.
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<li>We successfully designed composite parts with a copper chelator under control of a copper-sensitive promoter.
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Check out our <a href="https://2016.igem.org/Team:Oxford/Results#subB">results page</a> for more information.</li>
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<li>Discussions with the wider community played a major role in our project. We spoke to doctors and patients about Wilson’s Disease and used their feedback to guide our project. Check out our <a href=" https://2016.igem.org/Team:Oxford/Human_Practices"> Human Practices Hub</a> for more information.</li>
 
</ul>
 
</ul>
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</section>
  
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<section id="Bronze">
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<h2><font color="#cd7f32">Bronze</font></h2>
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<div class="h4Purple">
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Register for iGEM, have a great summer, and attend the Giant Jamboree.
 
</div>
 
</div>
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<p>
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We’re ready for Boston in every way after the summer of our lives. Counting down the days to the Giant Jamboree!
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</p><br>
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<div class="h4Purple">
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Meet all deliverables on the Requirements page</div>
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</p>
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<p>
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All submitted with love and hard work. Our judging form is <a href="https://igem.org/2016_Judging_Form?id=1980">here.</a>
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</p><br>
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<div class="h4Purple">
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Create a page on your team wiki with clear attribution of each aspect of your project.
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</div>
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<p>
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We have many to thank and you can find out about them <a href="https://2016.igem.org/Team:Oxford/Attributions">here.</a>
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</p><br>
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<div class="h4Purple">
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Document at least one new standard BioBrick Part or Device central to your project and submit this part to the iGEM Registry.
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</div>
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<p>
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BBa_K1980000 and BBa_K1980001 are both are new to the Registry. Find out more about them on our <a href="https://2016.igem.org/Team:Oxford/Parts"> Parts </a> page.
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</p>
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</section>
  
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<div class="column half_size">
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<section id="Silver">
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<h5>Safe Lab Work</h5>
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<h2><font color="#C0C0C0">Silver</font></h2>
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<div class="h4Purple">
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Experimentally validate that at least one new BioBrick Part or Device of your own design and construction works as expected.</div>
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<p>
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BBa_K1980003, BBa_K1980005, BBa_K1980007, BBa_K1980008 and BBa_K1980012 work as expected, hooray! See more information <a href="https://2016.igem.org/Team:Oxford/Results#subB">here.</a>
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</p><br>
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<div class="h4Purple">
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Convince the judges you have helped any registered iGEM team from high school, a different track, another university, or another institution in a significant way.</div>
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<p>
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We carried out all of the modelling for the Vilnius-Lithuania iGEM team, which can be seen on their <a href="https://2016.igem.org/Team:Vilnius-Lithuania/Collaborations#">wiki.</a> Additionally, we carried out a joint survey with the team, who have also been investigating a potential probiotic therapeutic, to investigate the perspectives of different cultures to probiotics and their application. <p>
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We sent XMU China parts generated by last year’s Oxford iGEM team that they had been unable to acquire themselves. <p>
  
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<p>What safety procedures do you use every day in the lab? Did you perform any unusual experiments, or face any unusual safety issues? Write about them here!</p>
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We also completed and shared the surveys of various teams! <p>
  
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</div>
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You can find out more about our collaborations <a href="https://2016.igem.org/Team:Oxford/Collaborations">here.</a></p><br>
 +
<div class="h4Purple">
 +
Demonstrate how your team has identified, investigated and addressed one or more questions relating to human practices.</div>
 +
<p>
 +
There are ethical and safety concerns regarding the use of a probiotic therapeutic. We discussed these issues with the Professor of Health, Law and Policy: Jane Kaye. Following her advice, we went to the public to discover their concerns. This acted as a springboard for our ethics and safety research. </p>
  
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<div class="column half_size">
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<p> Throughout the project we aimed to educate and engage the public on a local, national and international level! </p>
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<h5>Safe Shipment</h5>
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<p>Did you face any safety problems in sending your DNA parts to the Registry? How did you solve those problems?</p>
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<p> We also heavily integrated discussions with patients and doctors into our design. </p>
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</div>
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 +
<p> Find out more <a href="https://2016.igem.org/Team:Oxford/HP/Silver">here!</a></p>
  
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</section>
  
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<section id="Gold">
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<h2><font color="#FFD700">Gold</font></h2>
 +
<div class="h4Purple">
 +
Integrate the human practice issues into the design and/or execution of your project. </div>
 +
<p>
 +
From inception to execution, our Human Practice work has continually shaped our project. In creating a probiotic therapeutic, the opinions and thoughts of the public have continually been of huge importance, influencing the development of the project with regards to safety and ethics. However, our major concern was ensuring that our design met the needs and desires of Wilson’s Disease sufferers, to see how we integrated these discussions into our design, click <a href="https://2016.igem.org/Team:Oxford/HP/Gold">here.</a>
 +
</p> <br>
  
 +
<div class="h4Purple">
 +
Improve the function/characterisation of an existing BioBrick Part or Device. </div>
 +
<p>
 +
We have improved the function and characterisation of BBa_I760005, BBa_K190020, and BBa_K1758324. Click <a href="https://2016.igem.org/Team:Oxford/Description#Improve"> here </a> to see how!
 +
</p> <br>
 +
 +
<div class="h4Purple">
 +
Demonstrate a functional proof of concept. </div>
 +
<p>
 +
A key goal of our project was to produce a functional proof of concept: demonstrating that at least one of our promoter-driven devices was sensitive to copper, and that the addition of copper to a bacterial population containing this device would induce a measurable amount of protein expression. To see how we achieved this, click <a href="https://2016.igem.org/Team:Oxford/Proof">here!</a>
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</section>
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<div class="container-fluid">
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</body>
 
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{{:Team:Oxford/footer}}

Latest revision as of 23:11, 16 November 2016

iGEM Oxford 2016 - Cure for Copper

Achievements
Most of the team at our banner at the Jamboree

Our project was awarded a GOLD medal at the 2016 Jamboree.
We were nominated for: Best Therapeutic Project,
Best Wiki, Best Presentation and
Best Education & Public Engagement!

  • Developed an initial proof of concept for a Wilson’s Disease therapeutic as an alternative to current treatments, which have problems associated with their cost, side-effects and high dosage frequency.
  • We added 13 new BioBrick parts to the iGEM registry. Check our parts page for more information.
  • We investigated several different promoters and two different copper chelators with the aim of finding the most effective system.
  • We successfully designed composite parts with a copper chelator under control of a copper-sensitive promoter. Check out our results page for more information.
  • Discussions with the wider community played a major role in our project. We spoke to doctors and patients about Wilson’s Disease and used their feedback to guide our project. Check out our Human Practices Hub for more information.

Bronze

Register for iGEM, have a great summer, and attend the Giant Jamboree.

We’re ready for Boston in every way after the summer of our lives. Counting down the days to the Giant Jamboree!


Meet all deliverables on the Requirements page

All submitted with love and hard work. Our judging form is here.


Create a page on your team wiki with clear attribution of each aspect of your project.

We have many to thank and you can find out about them here.


Document at least one new standard BioBrick Part or Device central to your project and submit this part to the iGEM Registry.

BBa_K1980000 and BBa_K1980001 are both are new to the Registry. Find out more about them on our Parts page.

Silver

Experimentally validate that at least one new BioBrick Part or Device of your own design and construction works as expected.

BBa_K1980003, BBa_K1980005, BBa_K1980007, BBa_K1980008 and BBa_K1980012 work as expected, hooray! See more information here.


Convince the judges you have helped any registered iGEM team from high school, a different track, another university, or another institution in a significant way.

We carried out all of the modelling for the Vilnius-Lithuania iGEM team, which can be seen on their wiki. Additionally, we carried out a joint survey with the team, who have also been investigating a potential probiotic therapeutic, to investigate the perspectives of different cultures to probiotics and their application.

We sent XMU China parts generated by last year’s Oxford iGEM team that they had been unable to acquire themselves.

We also completed and shared the surveys of various teams!

You can find out more about our collaborations here.


Demonstrate how your team has identified, investigated and addressed one or more questions relating to human practices.

There are ethical and safety concerns regarding the use of a probiotic therapeutic. We discussed these issues with the Professor of Health, Law and Policy: Jane Kaye. Following her advice, we went to the public to discover their concerns. This acted as a springboard for our ethics and safety research.

Throughout the project we aimed to educate and engage the public on a local, national and international level!

We also heavily integrated discussions with patients and doctors into our design.

Find out more here!

Gold

Integrate the human practice issues into the design and/or execution of your project.

From inception to execution, our Human Practice work has continually shaped our project. In creating a probiotic therapeutic, the opinions and thoughts of the public have continually been of huge importance, influencing the development of the project with regards to safety and ethics. However, our major concern was ensuring that our design met the needs and desires of Wilson’s Disease sufferers, to see how we integrated these discussions into our design, click here.


Improve the function/characterisation of an existing BioBrick Part or Device.

We have improved the function and characterisation of BBa_I760005, BBa_K190020, and BBa_K1758324. Click here to see how!


Demonstrate a functional proof of concept.

A key goal of our project was to produce a functional proof of concept: demonstrating that at least one of our promoter-driven devices was sensitive to copper, and that the addition of copper to a bacterial population containing this device would induce a measurable amount of protein expression. To see how we achieved this, click here!