Difference between revisions of "Jamboree/Track Selection"

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When cancer hits,what can we do？Cheothearapy？Radiation？Or surgery？All above is a choice，but seems to do really a lot of harm to our body，killing cancer cells as well as regular cells.
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So,it occurs to us,why not let the cancer cells to apoptosis themselves?
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To activate apoptosis,we choose the mitochondria pathway.Let’s put it in a simple way:when there are more bax protein and less bcl-2 protein,the outer mitochondria membrane permeability will increase,releasing substance that will trigger caspase enzyme to cut the DNA,causing apoptosis.
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So how to regulate the genes?  
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Well,here comes the crispr system. Using a sgRNA to guide cas9 protein to a certain sequence and the cas9 protein will act as a DNA cutting enzyme.
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So, inactive the cas9 protein and attach it to VP64——substance that will attract transcription factors and the sgRNA will guide our cas9 protein to certain sequence,activating the transcription of bax gene, and in the end, we got more bax protein.  
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<h2>Track Selection</h2>
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And, inactive the cas9 protein and let the sgRNA guide it to a certain sequence that will block the way of transcription enzyme so that bcl-2 gene will not be able to transcripted, ending up in less bcl-2 protein.  
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<h3>Due August 12</h3>
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Next, we want to add tumour specific transcription promotor so that our crispr activate apoptosis sysmtem will only be triggered in tumout cells, protecting the normal cells.
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<h3>Final Tracks</h3>
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<p>For additional information about the iGEM 2016 project tracks, please visit the <a href="https://2016.igem.org/Tracks">Tracks page</a>.</p>
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<p>
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<ul>
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<li>Diagnostics </li>
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<li>Energy</li>
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<li>Environment</li>
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<li>Food and Nutrition</li>
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<li>Foundational Advance</li>
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<li>Hardware</li>
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<li>Health and Medicine</li>
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<li>Information Processing</li>
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<li>Manufacturing</li>
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<li>New Application</li>
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<li>Therapeutics</li>
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</ul>
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</p>
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<br>
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<h3>How to edit your track preferences</h3>
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<p>Please use the online track submission tool to submit your track preferences.</p>
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<br>
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<ul>
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<li>Log in to iGEM.org</li>
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<li>Select your team from the <a href="https://igem.org/Team_List?year=2016">Team List</a></li>
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<li>On your Team Information page, scroll down to the "Track" section and click on "Edit" above the gray box</li>
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<li>Select the appropriate tracks from the drop-down lists, and click "Save"</li>
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</ul>
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<br>
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<p>You can provide up to three track choices in order of preference, as you are not guaranteed your top choice. It is important that you submit your track selection on time, as the system will be closed on <strong>August 12</strong>.</p>
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<p>Questions can be emailed to <strong>hq AT igem DOT org</strong>.</p>
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Latest revision as of 18:18, 3 August 2016

Track Selection

Due August 12

Final Tracks

For additional information about the iGEM 2016 project tracks, please visit the Tracks page.

  • Diagnostics
  • Energy
  • Environment
  • Food and Nutrition
  • Foundational Advance
  • Hardware
  • Health and Medicine
  • Information Processing
  • Manufacturing
  • New Application
  • Therapeutics


How to edit your track preferences

Please use the online track submission tool to submit your track preferences.


  • Log in to iGEM.org
  • Select your team from the Team List
  • On your Team Information page, scroll down to the "Track" section and click on "Edit" above the gray box
  • Select the appropriate tracks from the drop-down lists, and click "Save"

You can provide up to three track choices in order of preference, as you are not guaranteed your top choice. It is important that you submit your track selection on time, as the system will be closed on August 12.

Questions can be emailed to hq AT igem DOT org.